Top Week 6 NFL Prop Bets (2025)

Last Updated October 9, 2025 7:48 am PDT
Denver Broncos wide receiver Courtland Sutton

Which starts should you target with your NFL prop bets this week? Only Houston and Minnesota are on byes, so there are 15 great Week 6 games with prop wagers to choose from this week. 

This guide highlights my favorite NFL prop bets for Week 6. I will tell you my top props and break down why each wager is worth betting on this weekend. 

Top NFL Player Props for Week 6

Lucky Rebel has hundreds of prop wagers for every game this weekend. Here are the four player props I recommend betting on the most in Week 6. 

Courtland Sutton 1st Drive Reception (-110)

Denver shocked Philadelphia last week, scoring 18 points in the fourth quarter to take down the then-undefeated Eagles. The Broncos (3-2) will look to keep that momentum going this week against the winless Jets in London. 

Bo Nix and company should have opportunities early and often against a Jets’ defense that allows 7.6 yards per pass attempt. New York also has just seven sacks this season and has yet to force a turnover

A pass-heavy attack will also help the Broncos build on their success from last week. With that in mind, I think Courtland Sutton is a good bet to get at least one reception on Denver’s first drive this week. 

Sutton leads the Broncos in targets (37), receptions (26), and receiving yards (365). He has been targeted on two of Denver’s five opening drives this season. On two of the three opening drives where Sutton was not targeted, the Broncos went three and out, so they should target him early. 

Jake Ferguson 1st Drive Reception (+105)

Another player who is a great bet to get a reception on the first drive this week is tight end Jake Ferguson. George Pickens has stepped into the WR1 role with CeeDee Lamb sidelined by an ankle injury. However, it is Ferguson that has been Dak Prescott’s favorite target this season. 

Ferguson leads Dallas in targets (48) and receptions (41) this season. He is second on the team in receiving yards with 272, including 154 yards after contact. Ferguson is also currently second, behind Puca Nacua (52), for the most receptions of any player this season. 

Dallas plays the Panthers in Carolina this week. The Panthers are tied for the fewest sacks in the league with five, and Prescott has only been sacked seven times. Carolina’s pass rush, or lack thereof, will give Prescott plenty of time to find his top target on the team’s opening drive. 

Jonathan Taylor, George Pickens, and De’Von Achane 4+ Combined TDs (+260)

Jonathan Taylor, George Pickens, and De’Von Achane have been among the most reliable TD scorers this season. This prop combines the three superstars into one wager. If Pickens, Taylor, and Achane score four combined TDs, you can get a +260 payout. 

Taylor leads the NFL in rushing with 480 yards so far this year. He also has seven total TDs and has scored three times in two of his last three games. 

Pickens and Achane have also been no strangers to the endzone this year, each scoring in four of their five games this year. Achane has only one rushing score, but he has three receiving TDs this season. Pickens has scored in four straight games and should find the endzone again this weekend. 

Ashton Jeanty, Josh Jacobs, and Tony Pollard 4+ Combined TDs (+240)

Another player prop special I recommend taking this week is for Ashton Jeanty, Josh Jacobs, and Tony Pollard to combine for 4+ TDs (+240).  

Jeanty has four TDs this year, but all of the rookie’s scores have come in two games. After a poor offensive performance last week, the Raiders should rely more on Jeanty this week against the lowly Titans, who have allowed a league-high 10 rushing TDs.

Jacobs, on the other hand, is coming off a bye week and should be well-rested for the Packers’ matchup against the porous Bengals’ defense. He has scored in three of Green Bay’s four games, including a two-TD performance against Dallas.

Tennessee’s offense has struggled this season, but Pollard has been one of the Titans’ best weapons. He has scored in two of his last three starts. Pollard faces an easy matchup against the Raiders, who have allowed the second-most rushing scores (8) this year. 

Best Week 6 NFL Game Prop Bets 

Lucky Rebel offers exciting game prop bets as well. Here are my top NFL game props for Week 6. 

Colts, Rams, and Cowboys Each Score 25+ Points (+325)

The Colts, Rams, and Cowboys are among the highest-scoring teams in the league this season. Detroit leads the league with 34.8 PPG, but Indianapolis is a close second at 32.6 PPG. The Cowboys (30.2 PPG) are also ranked in the top four scoring offenses this season. 

Los Angeles only averaged 24.6 PPG, but they face the easiest matchup of the week against Baltimore. The Ravens have allowed 35.4 PPG this year, the most in the NFL. 

With that in mind, I think the Colts, Rams, and Cowboys will all score at least 25 points (+325) this weekend. 

Lions Win and Both Teams Score 15+ Points (+220)

Speaking of the Lions, they take their high-flying offense on the road this weekend to face the Chiefs in Kansas City on Sunday Night Football. Despite having the best offense in football, Detroit is a +114 underdog against Kansas City. 

This prime-time matchup should be one of the best games of the weekend, and I believe the Lions will pull off the upset against the struggling Chiefs. KC is 2-3 and coming off a loss to the Jaguars on MNF. 

The Chiefs have scored at least 17 in every game this season, and the Lions have put up 34 points in four straight games. Both teams will score at least 15 points this week, but the Lions will get the road upset to improve to 5-1. 

Rams Win Both Halves (+140)

I picked Houston to win both halves against the Ravens (+350) in my Week 5 predictions. The Texans pulled through, leading 24-3 at halftime of their 44-10 road win. Baltimore is still one of the most beat-up teams in the league, and I believe they will lose both halves again this week. 

The Rams are listed at +140 to win both halves against Baltimore. LA has been a slow starter this season, winning the first half of just one of its games this year. 

On the bright side, the Ravens’ defense has allowed the most points in the NFL this season. The Ravens have trailed by at least 10 points at halftime in back-to-back games, and they will trail again at the half this week. 

Commanders, Bills, and Bears Each Score 20+ Points (+130)

Washington, Buffalo, and Chicago are three of the four teams featured in this week’s MNF doubleheader. This game prop will win if all three teams score at least 20 points in Week 6. 

These teams have been among the highest-scoring teams in the league this year.

Icon of football
  • Buffalo = 30.6 PPG – 3rd-most
  • Washington = 26.8 PPG – 8th-most
  • Chicago = 25.3 PPG – 11th-most

The Bills are coming off their worst game of the season, a 23-20 loss to New England. Their loss should give the Bills extra motivation this week against Atlanta. 

Washington and Chicago play each other, so a high-scoring game from one will force the other to put up points as well. Considering that, I think all three teams in this bet will score at least 20 points on MNF. 

Here are some tips and trends to keep in mind before placing your bets at top football betting sites this week.

Teams Usually Play Better After a Bye

Week 5 featured the first bye weeks of the season, giving four teams extra rest before their matchups this weekend. Having extra rest and more time to prepare usually gives teams coming off a bye an edge over their opponents the next week.

Do Not Overlook Travel and Weather Concerns

Travel, especially long flights for international games, can increase player fatigue. Simply put, tired teams tend to play worse. Weather conditions, such as rain and cold temperatures, will also become more of a factor as the season goes on.

Where to Bet on NFL Week 6 Props

For the best NFL prop bet odds this week, check out Lucky Rebel Sportsbook. It offers competitive odds on hundreds of props this week, including my favorite wager this week: the Colts, Rams, and Cowboys each score 25+ Points (+325). 

Football fans who sign up at Lucky Rebel this week can get up to $1,250 in bonus funds and 50 free spins with the site’s 125% welcome bonus. 

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Shaun
Stack
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Shaun Stack is new to GamblingSites.com but has been a professional gambling writer since 2021. His writing covers a broad spectrum of sports betting and casino topics. Shaun has been featured on over a dozen websites, including The New Jersey Digest, Space Coast Daily, and Gamble Critic. He is originally from Kansas City and has a bachelor's degree from the University of Pittsburgh Bradford.
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