Top Week 12 NFL Prop Bets (2025)

The best NFL prop bets in Week 12 highlight the biggest stars taking the field this weekend. It starts with a pivotal AFC clash on TNF, and the week continues with a stacked 12-game Sunday slate. 

Keep reading to see my picks for the best NFL prop bets available in Week 12. I break down my favorite props of the weekend and give my predictions for each wager. 

Best TNF Prop Bet: Woody Marks Anytime TD Scorer (+125)

Lucky Rebel Sportsbook lists Woody Marks at +125 to score a TD against the Bills on TNF. The rookie has been inconsistent this season, but he is in a prime position to have a breakout game against Buffalo. 

First, the Texans will be without C.J. Stroud as the third-year QB will miss his third game with a concussion. With Davis Mills under center, Houston should lean heavily on their rushing attack on a short week. Marks has 35 touches over the last two weeks with Stroud on the sideline.

Another factor in Marks’ favor is Buffalo’s poor run defense. The Bills give up 153 rushing YPG, the second-most in the NFL. 

A run-heavy attack against one of the softest run defenses in the league should lead to a productive day for Marks. The rookie will find the endzone at least once on TNF against Buffalo. 

Top NFL Player Props for Week 12

Top NFL betting sites have exciting player prop odds for Sunday’s games, too. Here are my top NFL player props for Week 12. 

Xavier Worthy Anytime TD Scorer (+230)

The Chiefs’ collective backs are against the wall after falling to 5-5 with back-to-back losses. Kansas City hosts the 8-2 Indianapolis Colts who were the number one seed before their bye last week. 

KC’s offense must be at the top of its game to compete with Indy. The Colts have been the most productive team in the league, scoring 32.1 PPG this season. 

Incorporating the speedy Xavier Worthy into the game plan is the best way to open up the offense for KC. He is listed at +230 to score this weekend. 

Worthy has an ankle injury, but if he does play, the speedster is a threat to score anytime he has the ball in his hands. Also, despite scoring just once this season, Worthy is averaging over 10 YPR this season. He is a solid bet to find the endzone this week for a desperate Chiefs team.  

Christian Watson 1st Drive Reception (+175)

Speaking of receivers who started slow, Christian Watson missed the first six games of the season while recovering from a torn ACL he suffered last season. Watson was scoreless in his first three games back, but he finally broke through last week. 

Jordan Love targeted Watson a season-high five times. Watson caught four of his targets and scored a pair of TDs against the Giants, cashing his anytime TD scorer props in Week 11. 

With RB Josh Jacobs questionable with a knee injury, Watson should be an even bigger part of the offense this week against Minnesota. He is listed at +175 to score a TD against the Vikings this Sunday. 

Minnesota only allows 190.5 passing YPG, the seventh-fewest in the NFL. However, they have allowed 14 passing TDs this season and have forced only 3 INTs. A Jacobs-less Packers offense can test Minnesota’s defense, and Watson will turn his extra targets into at least one TD this weekend. 

Jared Goff Longest Completion Over 35.5 Yards (-110)

Jared Goff and the Lions are coming off their worst game of the season, scoring just nine points in their loss to the Eagles on Sunday Night Football. Detroit hosts the Giants this week, giving them a perfect opportunity to bounce back. 

New York allows over 375 YPG, the fourth-most in the league. A lot of the damage has been on the ground, with the Giants surrendering nearly 150 rushing YPG to opposing teams. 

The Lions have struggled to run the ball at times, but they have excelled at turning short passes into long gains. Goff has a completion of at least 40 yards in three straight games as a result. He has a long of 36+ yards in five of his 10 starts this season. 

Goff is listed at -110 to have a completion of over 35.5 yards this weekend against the Giants. New York has allowed 32 passes of 20+ yards, tied for the 10th-most in the NFL. The G-Men’s defense is vulnerable to big plays, and Goff will complete at least one pass for more than 35.5 yards this Sunday. 

DeVonta Smith Anytime TD Scorer (+170)

The much-maligned Eagles’ passing attack will be tested again this week as Philadelphia heads to Jerry World. Dallas’s offense has been the second-most productive unit in the NFL, scoring 29.6 PPG. 

In three of their four home games, the Cowboys have scored at least 40 points. Philadelphia’s defense is tough, but its offense will have to score points to keep up with Dallas. 

While AJ Brown has complained about his lack of targets, DeVonta Smith has quietly led the Eagles in targets (67), receptions (49), and receiving yards (665) this season. He is listed at +170 to score his fourth TD of the season this week. 

Dallas presents an ideal opponent for any challenging offense. The Cowboys have allowed 249.9 passing YPG, the third-most in the NFL, and 23 passing TDs, second-most in the league. Smith will find the endzone this week against the Cowboys’ porous pass defense. 

Best Week 12 NFL Game Prop Bets 

You can wager on exciting game props this weekend, too. Here are my top game props for Week 12. 

Cleveland Browns Win Both Halves (+575)

The Browns (2-8) take on the Raiders (2-8) this weekend in Las Vegas. Cleveland has the fourth-worst offense in the NFL, scoring just 16.2 PPG. They are also starting Shedeur Sanders for the first time this weekend. 

One of the few offenses worse than the Browns is the Raiders. Las Vegas has managed just 15.5 PPG, tied for the second-fewest in the league. 

Cleveland’s defense will be the deciding factor in this game. The Browns’ pass rush has been dominant, racking up 32 sacks this season. Las Vegas QB Geno Smith, on the other hand, has been sacked  31 times, the fourth-most in the league. 

The Browns’ pass rush will take over the game, allowing Cleveland to win both halves (+575) on the road this week. 

Seattle Seahawks -14.0 (+100)

Seattle is coming off a tough loss last week, missing a game-winning field goal against division rival LA. The Seahawks are in a great position to bounce back this week against Tennessee.

Oddsmakers listed Seattle as 13.0-point favorites on the road. Pushing that to 14.0 points rewards you with even-money odds in this alternate point spread bet. 

Covering 14.0 points is a tough ask in the NFL, but this Seattle offense is more than capable of doing it. The Seahawks average 29.4 PPG, the third-most in the league. Tennessee, on the other hand, averages 14.3 PPG, the worst in the NFL, while giving up 27.3 PPG, the third-most. 

New England Patriots -9.5 (+109)

New England is another favorite that can easily cover their point spread this weekend. The Patriots are listed as 6.5-point favorites against the Bengals. 

Cincinnati will be without Ja’Marr Chase, who was suspended. His absence will allow the Pats to focus on stopping Tee Higgins, effectively kneecapping the Bengals’ explosive offense. 

For its part, New England has averaged 26.5 PPG on offense, seventh-most so far this season. Their high-scoring offense should dominate a Bengals’ defense that has allowed 33.4 PPG, the most by far this season. New England should win by double digits and cover this alternate line of 9.5 points. 

Los Angeles Rams -0.5 in the 1st Quarter (+102)

The Rams (8-2) continue their march toward an NFC West title this week with a home date against the NFC South-leading Buccaneers (6-4). Tampa Bay has lost three of four and is an underdog at SoFi in this prime time matchup. 

Los Angeles is a 6.5-point favorite overall, but you do not need to wait until the game is over to cash in. The Rams are listed as 0.5-point favorites in the first quarter. 

Matthew Stafford and company have been rolling lately, while Baker Mayfield and the Bucs have struggled to recreate their early season success. LA should take an early lead and cover a 0.5-point spread in the opening quarter. 

Week 12 NFL Prop Betting Trends and Tips

Account for these NFL betting tips and trends when making your wagers this weekend.

Where to Bet on NFL Week 12 Props

Lucky Rebel is the top place to wager on your NFL prop bets for Week 12. It has a user-friendly UI that makes it easy to find updated lines for every game. 

New members can use the 125% welcome bonus to gain up to $1,250 in bonus funds with their first deposit at Lucky Rebel. This exciting welcome bonus also includes 50 free spins at the site’s top-rated casino.