75%
USA
Canada
Australia
UKNFL Picks for Week 3 (2025)
Week 3 is chock-full of great matchups that make for exciting NFL picks this weekend. The week starts with a Thursday night AFC East battle in Buffalo and ends with two Super Bowl contenders squaring off on Monday Night Football.
I will break down the latest odds for every game on the Week 3 schedule below. Additionally, I will share my updated NFL predictions and best bets for this week.
Latest Week 3 NFL Odds
Here are the latest NFL odds for Week 3, provided by Lucky Rebel Sportsbook.
| Matchup | Moneyline | Point Spread |
|---|---|---|
| Miami Dolphins vs. Buffalo Bills | Dolphins (+500) vs. Bills (-800) | Bills -12.0 (-110) |
| Atlanta Falcons vs. Carolina Panthers | Falcons (-250) vs. Panthers (+195) | Falcons -5.0 (-113) |
| Green Bay Packers vs. Cleveland Browns | Packers (-430) vs. Browns (+320) | Packers -7.5 (-112) |
| Houston Texans vs. Jacksonville Jaguars | Texans (-105) vs. Jaguars (-117) | Jaguars -1.0 (-109) |
| Cincinnati Bengals vs. Minnesota Vikings | Bengals (+139) vs. Vikings (-170) | Vikings -3.0 (-115) |
| Pittsburgh Steelers vs. New England Patriots | Steelers (-125) vs. Patriots (+102) | Steelers -1.5 (-109) |
| Los Angeles Rams vs. Philadelphia Eagles | Rams (+158) vs. Eagles (-195) | Eagles -3.5 (-103) |
| New York Jets vs. Tampa Bay Buccaneers | Jets (+275) vs. Buccaneers (-360) | Buccaneers -7.5 (-104) |
| Indianapolis Colts vs. Tennessee Titans | Colts (-190) vs. Titans (+153) | Colts -3.5 (-106) |
| Las Vegas Raiders vs. Washington Commanders | Raiders (+153) vs. Commanders (-186) | Commanders -3.5 (-110) |
| Denver Broncos vs. Los Angeles Chargers | Broncos (+119) vs. Chargers (-145) | Chargers -2.5 (-110) |
| New Orleans Saints vs. Seattle Seahawks | Saints (+290) vs. Seahawks (-390) | Seahawks -7.0 (-118) |
| Dallas Cowboys vs. Chicago Bears | Cowboys (-103) vs. Bears (-118) | Bears -1.0 (-112) |
| Arizona Cardinals vs. San Francisco 49ers | Cardinals (+106) vs. 49ers (-130) | 49ers -1.5 (-113) |
| Kansas City Chiefs vs. New York Giants | Chiefs (-285) vs. Giants (+220) | Chiefs -6.0 (-113) |
| Detroit Lions vs. Baltimore Ravens | Lions (+225) vs. Ravens (-290) | Ravens -6.0 (-107) |
Buffalo has scored 71 points combined in its first two games. So, it comes as no surprise that the Bills are the biggest favorites of the week at -12.0 against the Dolphins (0-2) this Thursday.
Sunday’s slate also includes divisional matchups, such as Falcons vs. Panthers, Texans vs. Jaguars, and Colts vs. Titans.
Injuries were a big part of many outcomes in Week 2, and they will play a major role this week, too. With both starters going down last week, it will be a battle of backup quarterbacks as the Bengals take on the Vikings in Minnesota. The Carson Wentz-led Vikes are home favorites over Jake Browning’s Bengals.
Read this free and honest Lucky Rebel review to learn more about this sportsbook.
Week 3 NFL Picks
There are plenty of exciting betting options for this week’s games. Here are my favorite Week 3 NFL picks available at top NFL betting sites.
Best Week 3 NFL ML Picks (Straight Up)
Indianapolis is an early leader for the surprise team of the season. The Colts are 2-0, and Daniel Jones is playing better than he ever did in a Giants uniform. Indy is a -190 favorite over the Titans, and the Colts’ defense will smother rookie Cam Ward as the Colts move to 3-0.
Another moneyline favorite I am high on this week is the Chargers. Los Angeles is a -145 favorite against the Denver Broncos in LA’s third divisional game in as many weeks. Bo Nix’s sophomore slump will cost the Broncos again this week, and LA will pick up its third AFC West win of the year.
Speaking of AFC West teams, the Chiefs (0-2) take on the Giants (0-2) in New York on Sunday Night Football. Kansas City has struggled to start the year and has lost three consecutive games for the first time in the Patrick Mahomes era. KC has a lot of issues to work out, but they will pick up their first win of the year in prime time this week.
Week 3 NFL Picks ATS
Next on my NFL picks for Week 3 are my top point-spread wagers.
Miami is the biggest underdog of the week at +12.0 points for their TNF matchup with the Bills. The Dolphins’ offense improved significantly last week, but they still lost to New England. Buffalo should win this game easily, but Miami’s offense is explosive enough to cover the 12.0-point spread in this divisional game.
Another point-spread I recommend taking this week is Eagles -3.5 against the Rams. Philadelphia’s offense has not looked great this year, but the Rams could be the perfect remedy for that. Saquon Barkley had over 200 rushing yards in both games against LA last year, and he will carry the Eagles to a win of at least 3.5 points this weekend.
Rounding out my NFL picks ATS this week are the Lions. Detroit is getting 6.0 points against the Ravens for their MNF matchup in Baltimore. The Lions offense put up 52 points last week, and the momentum from that performance will help them cover the spread this week.
Best Week 3 NFL Upset Picks
Two of my three NFL Week 2 upset picks pulled off the win. This week, I am picking the Bengals (+139), Patriots (+102), and Cowboys (-103) to win as underdogs.
Cincinnati lost Joe Burrow for most of the year after the MVP candidate suffered a grade 3 turf toe injury. On the bright side, Minnesota is also starting a backup in Carson Wentz. Jake Browning has had success in short stints for the Bengals before, and Cincy’s playmakers are good enough to beat Minnesota this week.
New England earned its first win under coach Mike Vrabel last week with a 33-27 win in Miami. The Patriots are home underdogs this week against the Steelers. Pittsburgh’s normally stout defense has been unrecognizable this season, and New England will defend home field this weekend.
Rounding out my underdog picks for Week 3 are the Cowboys, who picked up their first win of the year with Sunday’s 40-37 shootout victory in overtime. Dallas is on the road this week against the 0-2 Bears, who were blown out by the Lions last week. The Cowboys should pick up the road win and improve to 2-1 under Brian Schottenheimer.
NFL Week 3 Predictions
Green Bay (-430) is my lock of the week. The Packers’ ML odds do not offer much value, but their defense should shut down the Browns on Sunday. Cleveland’s defense will also provide a good test for the Packers’ offense.
The Texans’ surprising 0-2 start has alarm bells ringing in Houston. On the bright side, C.J. Stroud and company have a great opportunity to address concerns in their Week 3 matchup against the Jaguars. Jacksonville lost to Cincy, who was without Joe Burrow for most of the game, and they will drop another game this week against Houston.
Washington (-186) is a risky bet heading into Week 3. If Jayden Daniels is healthy enough to play, the Commanders should easily beat Las Vegas. On the other hand, if Daniels is out, then the Raiders could make an intriguing underdog pick.
Where to Make Winning Week 3 NFL Picks
Lucky Rebel is the ideal sportsbook for every football fan looking to wager on Week 3 NFL picks. You can wager on every game this week, including prime time matchups and my top bet for this week: Green Bay (-430) against Cleveland.
New members who make a qualifying deposit can also get a 125% deposit match this week. The bonus also includes free spins in the site’s highly-rated casino.
Want more NFL betting advice? Check out our Week 3 NFL player props.
