NFL Picks for Week 15 (2025)

Every team has had its regular-season bye, meaning all 32 clubs are available in this week’s NFL picks. The pressure on every team is also at a season-high with the playoffs right around the corner.

Continue reading to see my NFL predictions for every Week 15. In addition to picking the winner of every game, I also highlight my favorite moneyline, ATS, and underdog picks for this weekend in the NFL. 

Latest Week 15 NFL Odds

Here are the latest odds for your Week 15 NFL picks, courtesy of Lucky Rebel.    

Week 15 starts with an AFC South clash, as the Buccaneers lay 4.0 points against the visiting Falcons. Atlanta’s season is over, but they can deal a major blow to Tampa Bay’s division hopes with an upset. 

On Sunday, the early window features a must-see game between the Patriots (11-2) and the Bills (9-4). Buffalo is a 1.0-point road favorite in a game they need to win to have a chance at catching the Pats for first place in the AFC East. 

Lucky Rebel is the best place to wager on every matchup in Week 15. Sign up today to shop the latest odds or read this free Lucky Rebel review to find out everything you need to know about this top-rated sportsbook. 

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Week 15 TNF Best Bet: Tampa Bay Buccaneers (-235)

• Atlanta has lost 7 of its last 8 games and is 2-5 as a road team this season.
• Tampa Bay is 2-1 against divisional opponents and is desperate for a bounce-back win after last week’s loss to the Saints.
• The Falcons allow over 130 rushing YPG, ninth-most, which should allow the Bucs to lean on their rushing attack and take pressure off the injured Baker Mayfield.

Tampa Bay failed to capitalize on a golden opportunity to extend its lead in the NFC South last week. The Buccaneers’ loss to the Saints dropped Tampa Bay to 7-6, and they are now tied with the Panthers for the division’s best record.

Baker Mayfield and company have another great chance at a division win this week as they take on the Falcons. Atlanta is 4-9 after losing seven of its last eight games, including a 37-9 blowout loss last week to Seattle. 

Mayfield is playing through injuries, but Tampa Bay can lessen the load on their QB by leaning into their rushing attack. Atlanta allows over 130 rushing YPG, so Bucky Irving and company should have plenty of running room this weekend. 

The Bucs are favored by 4.0 points, but their injuries and recent struggles make them a risky bet to cover in this divisional matchup. However, I do think Tampa Bay will win and recommend taking their moneyline odds at -235. 

Week 15 NFL Picks 

The top NFL betting sites offer competitive lines for the other 15 games on this week’s schedule, too. Here are my top NFL picks for Week 15. 

Best Week 15 NFL ML Picks (Straight Up)

• Baltimore Ravens (-147) – Bet now!
• Carolina Panthers (-150) – Bet now!
• Dallas Cowboys (-300) – Bet now!

Baltimore has lost back-to-back divisional games, falling below .500 with their loss against the Steelers last week. The Ravens can get back on track with a win over the Bengals this Sunday. Lamar Jackson and the offense should have learned from their struggles against Cincy on Thanksgiving and will secure the season split as -147 road favorites this weekend. 

Another team looking to even the season series against a divisional opponent this week is Carolina, which is listed at -150 to beat New Orleans. The Panthers lost at home to the Saints 17-7 in Week 10. Carolina is 2-1 since that loss, including a win over the Rams, and had a bye to prepare for this game, so they should win. 

Dallas is listed as a -300 favorite against the Vikings on Sunday Night Football. Minnesota had a massive 31-0 win over Washington last week, but its offensive inconsistency is a big reason they are 5-8 this season. The Vikings’ offensive issues will prevent them from keeping up with the high-flying Cowboys, and Dallas will win.

Week 15 NFL Picks ATS

• Arizona Cardinals +10.0 (-114) – Bet now!
• Washington Commanders +2.5 (-110) – Bet now!
• Detroit Lions +5.5 (-106) – Bet now!

Arizona kept pace with the Rams early last week, tying the game 10-10 midway through the second quarter. Unfortunately, they could not continue at that pace, losing 45-17 and failing to cover their Week 14 spread. The Cards are getting 10.0 points this week against the Texans, and Arizona should have an easier time covering against a struggling Houston offense. 

Washington also lost in a blowout last week, but the Commanders should be better this week if Jayden Daniels can play the whole game. They are 2.5-point underdogs against the 2-11 Giants this weekend. New York has lost seven straight games and has a -88 point differential, so the Commanders should at least cover this weekend. 

Detroit beat the Cowboys on TNF last week, but they are 5.5-point underdogs this Sunday against the Rams. The Lions have not won back-to-back games since Week 5, and LA has one of the best offenses. Detroit’s offense is also one of the best in the league, so the Lions should cover the 5.5-point spread.

Best Week 15 NFL Upset Picks

• New England Patriots (-107) – Bet now!
• Denver Broncos (+117) – Bet now!
• Miami Dolphins (+149) – Bet now!

New England won 10 straight games before its bye, including a win over the Bills in Buffalo back in Week 5. Despite that win, the Patriots are -107 home underdogs against the Bills (-113) in the rematch this weekend. Bottling up Josh Allen again will be easier said than done, but if the Pats pull it off, they can also lock up the AFC East title this weekend. 

Another home underdog this week is Denver, which is listed at +117 against the visiting Packers. The Broncos have won 10 straight games and can take another step toward securing the number one seed with a win this weekend. If the Broncos’ defense can shut down Josh Jacobs and Jordan Love, Denver will secure an upset on Sunday. 

Tua Tagovailoa earned his first career win in under 45-degree weather with Miami’s dominant 34-10 victory over the Jets last week. The Dolphins relied heavily on their rushing attack and can follow a similar script this week against the Steelers. A run-heavy game plan against the Steelers’ 21st-ranked run defense will lead Miami to a win on Monday Night Football this weekend.

NFL Week 15 Predictions

Jacksonville is a -850 favorite over the Jets, and a win will move the Jaguars one step closer to locking up the AFC South. The Jags have won four straight, putting up 25+ points in every game of their winning streak. Jacksonville’s top-rated run defense will shut down the Jets’ rushing attack and lead the Jags to a vital win this weekend. 

Kansas City must win out, and get a lot of help, to make the playoffs after falling to 6-7. The Chiefs are -240 home favorites against the Chargers on Sunday. LA’s offensive injuries will keep them from pulling off the season sweep against a desperate Chiefs team this weekend. 

Seattle is the top seed in the NFC, for now, and a -1000 favorite against the Colts on Sunday. Indianapolis signed the previously retired Philip Rivers to its practice squad, and he could start for the Colts in this game. The Seahawks defense is set up for a big day regardless of whom Indy starts, and they will win this weekend. 

Where to Make Your Week 15 NFL Picks

The top place to bet on your NFL picks in Week 15 is Lucky Rebel. It offers updated, competitive lines for all 16 games on this week’s schedule. You can also wager on my top pick of the week: the Miami Dolphins (+149) to upset the Pittsburgh Steelers on MNF. 

Lucky Rebel also offers exciting bonuses, including a 125% welcome bonus for new members worth up to $1,250 in bonus funds. This welcome offer is perfect for betting on your NFL picks against the spread and moneyline predictions in Week 15.