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UKWeek 8 College Football Picks (2025)
Our Week 8 college football picks feature multiple ranked vs. ranked matchups, including long-standing SEC rivalries. Notre Dame also takes on USC this weekend in a battle for the Jeweled Shillelagh.
Keep reading to see the latest odds for every ranked team this week in college football. I discuss the updated betting odds and highlight my best bets this week in college football.
Week 8 College Football Odds (Top 25)
Lucky Rebel provided the following odds for every game featuring a ranked team in Week 8.
| Matchup | Favorite | Underdog | Points Spread |
|---|---|---|---|
| Louisville vs. #2 Miami | #2 Miami (-575) | Louisville (+400) | #2 Miami -13.5 (-114) |
| #25 Nebraska vs. Minnesota | #25 Nebraska (-305) | Minnesota (+240) | #25 Nebraska -8.0 (-111) |
| #10 LSU vs. #17 Vanderbilt | #17 Vanderbilt (-138) | #10 LSU (+113) | #17 Vanderbilt -2.5 (-113) |
| #12 Georgia Tech vs. Duke | Duke (-122) | #12 Georgia Tech (+100) | Duke -1.5 (-109) |
| #14 Oklahoma vs. South Carolina | #14 Oklahoma (-225) | South Carolina (+180) | #14 Oklahoma -5.5 (-110) |
| #1 Ohio State vs. Wisconsin | #1 Ohio State (-5000) | Wisconsin (+1300) | #1 Ohio State -25.0 (-110) |
| Michigan State vs. #3 Indiana | #3 Indiana (-5000) | Michigan State (+1300) | #3 Indiana -27.0 (-113) |
| #4 Texas A&M vs. Arkansas | #4 Texas A&M (-310) | Arkansas (+240) | #4 Texas A&M -7.5 (-111) |
| #5 Ole Miss vs. #9 Georgia | #9 Georgia (-300) | #5 Ole Miss (+230) | #9 Georgia -7.5 (-108) |
| #7 Texas Tech vs. Arizona State | #7 Texas Tech (-340) | Arizona State (+260) | #7 Texas Tech -8.0 (-109) |
| #22 Memphis vs. UAB | #22 Memphis (-1800) | UAB (+875) | #22 Memphis -21.5 (-111) |
| #8 Oregon vs. Rutgers | #8 Oregon (-850) | Rutgers (+550) | #8 Oregon -17.5 (-105) |
| Washington State vs. #18 Virginia | #18 Virginia (-950) | Washington State (+600) | #18 Virginia -17.0 (-115) |
| #21 Texas vs. Kentucky | #21 Texas (-490) | Kentucky (+360) | #21 Texas -12.5 (-112) |
| #11 Tennessee vs. #6 Alabama | #6 Alabama (-320) | #11 Tennessee (+250) | #6 Alabama -8.5 (-108) |
| #20 USC vs. #13 Notre Dame | #13 Notre Dame (-355) | #20 USC (+270) | #13 Notre Dame -9.5 (-114) |
| Florida Atlantic vs. #19 South Florida | #19 South Florida (-1900) | Florida Atlantic (+900) | #19 South Florida -22.0 (-111) |
| #16 Missouri vs. Auburn | #16 Missouri (-130) | Auburn (+106) | #16 Missouri -2.0 (-112) |
| #23 Utah vs. #15 BYU | #23 Utah (-172) | #15 BYU (+141) | #23 Utah -3.5 (-102) |
| #24 Cincinnati vs. Oklahoma State | #24 Cincinnati (-1800) | Oklahoma State (+875) | #24 Cincinnati -21.5 (-110) |
For the first time in a long time, every team in the AP Top 25 rankings is in action this week. There are multiple ranked vs. ranked matchups, too, including:
- #10 LSU vs. #17 Vanderbilt
- #5 Ole Miss vs. #9 Georgia
- #11 Tennessee vs. #6 Alabama
- #20 USC vs. #13 Notre Dame
- #23 Utah vs. #15 BYU
The home team is the favorite in four of the five ranked vs. ranked games this week. The only exception is #15 BYU. Despite being the higher-ranked team and playing at home, the Cougars are getting 3.5 points against the visiting Utes.
Only one ranked team, #12 Georgia Tech, is an underdog against an unranked opponent this week. The 6-0 Yellow Jackets are getting 1.5 points on the road against the Duke Blue Devils.
Our Lucky Rebel review provides more details about the sportsbook that provided the odds for this week’s college football picks.
Best Week 8 College Football Picks
Here is an in-depth look at my top college football predictions for Week 8.
Straight Up/ML Picks
The #7 Texas Tech Red Raiders jumped up two spots this week after dominating KU 41-17. Texas Tech has not allowed more than 17 points in any game and has scored at least 34 points every week. I picked the Red Raiders in my Week 7 best bets, and I am riding with them again as -340 favorites against 4-2 Arizona State.
Another Texas team in the top 10 that I like to win this week is #4 Texas A&M. The Aggies are listed at -310 favorites to beat the Razorbacks. Arkansas is 2-4 this season and will lose its fifth straight game this week.
One of the new additions to the rankings this week is #24 Cincinnati. The Bearcats earned their spot in the Top 25 by taking down Iowa State and UCF in back-to-back weeks. Cincinnati has not lost since Week 1, and the 1-5 OSU Cowboys are not ending that streak this weekend.
Best ATS Picks
The Sooners lost Red River last week, dropping from #6 to #14 in the rankings. Oklahoma has a great chance to bounce back this week against South Carolina (3-3). The Sooners are laying 5.5 as road favorites, and they will cover against a Gamecocks team that is 1-3 against SEC opponents this year.
Speaking of SEC matchups, the #11 Tennessee Volunteers take on the #6 Alabama Crimson Tide in Tuscaloosa this week. The Vols are getting 8.5 points in this ranked vs. ranked matchup. Tennessee has not won in Bryant-Denny Stadium since 2003, but its explosive offense will cover the spread this week.
Missouri dropped two spots to #16 after losing to Alabama at home last week. The Tigers can get back in the win column this weekend with a matchup against unranked Auburn. Mizzou is laying 2.0 points on the road and will cover in this battle of Tigers mascots.
Top CFB Upset Picks
The #12 Georgia Tech Yellow Jackets are undefeated, but they are road underdogs this week against Duke. Georgia Tech has scored 30+ points in four of its six games this season. The Yellow Jackets’ offense will carry them to an upset win this weekend against a Duke team that gives up over 375 YPG.
#5 Ole Miss is an underdog on the road this week against #9 Georgia. The Bulldogs’ passing struggles cost them against Alabama two weeks ago. If they struggle again this week, Georgia will not be able to keep up with a Rebels team averaging 311 passing YPG this season.
The #20 USC Trojans are +270 underdogs against #13 Notre Dame this weekend. USC earned a major win over then-#15 Michigan last week, and they will bet another Top 15 this week when they take down the Fighting Irish. The Trojans have the second-most productive offense in college football, averaging 552.3 YPG, and they will overwhelm Notre Dame this weekend.
Top Week 8 College Football Prop Bets
LSU and Vanderbilt square off in a matchup that will shake up the AP Top 25. These Top 25 teams are both averaging over 25 PPG this season. I think their high-scoring offenses will put up points again this week, with LSU and Vanderbilt combining to cover an alternate total of 50.0 points.
Memphis moved up to #22 after dominating Tulsa 45-7 last week. They face another easy opponent this week in a UAB team that gives up 41.3 PPG., the most in college football, and recently fired its head coach. Memphis should easily cover its first-half total of 14.0 points this weekend.
Finally, #22 Utah and #15 BYU battle it out for supremacy in the Beehive State. The Utes and Cougars average 39.5 and 37.5 PPG, respectively. With that in mind, I think these high-scoring offenses will combine for at least 10.0 points in the first quarter of this in-state rivalry matchup.
Betting on College Football in Week 8
The best NCAAF betting sites offer competitive lines for all your college football picks in Week 8. See the guide above for the latest odds and my best bets of the weekend, including my favorite wager: #16 Missouri -2.0 (-112) vs. Auburn.
See the updated odds and wager on your Week 8 predictions today at Lucky Rebel. If you create a new account today, you can get up to $1,250 in bonus funds if you qualify for the 125% welcome bonus promotion.
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