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UKWeek 10 College Football Picks (2025)
Making the right college football picks is the key to enjoying a winning weekend. There are three ranked vs. ranked matchups, and #1 Ohio State looks to stave off #2 Indiana to remain at the top of the rankings.
Keep reading for a closer look at the updated college football odds for Week 10. I analyze the odds from every game and highlight my favorite bets in college football this weekend.
Week 10 College Football Odds (Top 25)
Lucky Rebel has the following odds available for your college football picks in Week 10.
| Matchup | Favorite | Underdog | Points Spread |
|---|---|---|---|
| #25 Memphis vs. Rice | #25 Memphis (-625) | Rice (+440) | #25 Memphis -14.0 (-110) |
| Penn State vs. #1 Ohio State | #1 Ohio State (-1600) | Penn State (+825) | #1 Ohio State -21.0 (-105) |
| #9 Vanderbilt vs. #20 Texas | #20 Texas (-138) | #9 Vanderbilt (+114) | #20 Texas -2.5 (-112) |
| #10 Miami vs. SMU | #10 Miami (-470) | SMU (+350) | #10 Miami -12.5 (-110) |
| West Virginia vs. #22 Houston | #22 Houston (-585) | West Virginia (+415) | #22 Houston -13.0 (-115) |
| #16 Louisville vs. Virginia Tech | #16 Louisville (-390) | Virginia Tech (+295) | #16 Louisville -10.0 (-114) |
| #2 Indiana vs. Maryland | #2 Indiana (-1800) | Maryland (+850) | #2 Indiana -21.5 (-108) |
| #5 Georgia vs. Florida | #5 Georgia (-285) | Florida (+225) | #5 Georgia -7.0 (-116) |
| #12 Notre Dame vs. Boston College | #12 Notre Dame | Boston College | #12 Notre Dame -28.5 (-116) |
| #13 Texas Tech vs. Kansas State | #13 Texas Tech (-285) | Kansas State (+225) | #13 Texas Tech -7.0 (-112) |
| #15 Virginia vs. California | #15 Virginia (-198) | California (+161) | #15 Virginia -4.5 (-105) |
| South Carolina vs. #7 Ole Miss | #7 Ole Miss (-490) | South Carolina (+360) | #7 Ole Miss -12.5 (-112) |
| Purdue vs. #21 Michigan | #21 Michigan (-1800) | Purdue (+875) | #21 Michigan -21.5 (-112) |
| #8 Georgia Tech vs. NC State | #8 Georgia Tech (-210) | NC State (+170) | #8 Georgia Tech -5.5 (-109) |
| #18 Oklahoma vs. #14 Tennessee | #14 Tennessee (-160) | #18 Oklahoma (+132) | #14 Tennessee -3.0 (-112) |
| #23 USC vs. Nebraska | #23 USC (-225) | Nebraska (+180) | #23 USC -6.0 (-110) |
| #17 Cincinnati vs. #24 Utah | #24 Utah (-340) | #17 Cincinnati (+260) | #24 Utah -9.0 (-111) |
There are three ranked vs. ranked matchups this week, including: #9 Vanderbilt vs. #20 Texas, #18 Oklahoma vs. #14 Tennessee, and #17 Cincinnati vs. #24 Utah. All three home teams are favored in these matchups between ranked teams.
#1 Ohio State and #2 Indiana are both laying 21+ points in their respective matchups. The heaviest favorite of the weekend, though, is #12 Notre Dame at -28.5 against Boston College.
The five AP Top 25 teams not playing this weekend are:
- #3 Texas A&M
- #4 Alabama
- #6 Oregon
- #10 BYU
- #19 Missouri
Our Lucky Rebel review breaks down everything you need to know about this highly-rated sportsbook.
Best Week 10 College Football Picks
Let’s dive deeper into my top Week 10 college football predictions.
Straight Up/ML Picks
#13 Texas Tech faces a tough test against Kansas State this week. The Wildcats were ranked in the preseason but fell out of the Top 25 thanks to their 4-4 record. Texas Tech will win, setting up a must-see game with #10 Utah next weekend.
Another favorite who will win outright this week is #8 Georgia Tech. The Yellowjackets (8-0) take on the NC State Wolfpack (4-4) at Carter-Finley Stadium this weekend. NC State is just 1-3 in ACC play this year and will lose its fourth conference game this week.
#14 Tennessee can break into the playoff picture with a win over #18 Oklahoma this weekend. The Volunteers need a signature win over a ranked team this season, and this is their best shot to get it. Tennessee wins, handing the Sooners their third SEC loss and potentially knocking them out of the Top 25.
Best ATS Picks
#10 Miami bounced back from its loss to Louisville with a 42-7 shellacking of Stanford. The Hurricanes are laying 12.5 this week at SMU. Miami will win and cover against a Mustangs team that managed just 12 points in last week’s loss to Wake Forest.
Another ranked favorite who will cover this week is #5 Georgia. The Bulldogs are laying 7.0 points against Florida (3-4). The Gators are 1-3 against ranked opponents this year, and Georgia should easily win this game.
Virginia jumped one spot to 15th in the Top 25 after doing just enough to win as a betting favorite last week over UNC. The Cavaliers, who have won six straight games, are 4.5-point favorites at Cal this weekend. Virginia’s offense, which averages 37.1 PPG, will get back to its high-scoring ways this week and cover against the Golden Bears.
Top CFB Upset Picks
Starting my upset picks this week is #9 Vanderbilt, which is a +114 road underdog against #20 Texas this weekend. The Commodores are rolling after taking down LSU and Mizzou in back-to-back weeks. Vandy will win its third straight game against a ranked opponent this week at Texas Memorial Stadium.
Nebraska (6-2) hosts #23 USC (5-2) this week in an important Big Ten matchup. The Trojans have lost two of their last three, and they have allowed 31+ points in three of their last four. Nebraska averaged 35.0 PPG, and the Cornhuskers’ offense will lead them to an upset win.
#17 Cincinnati is a +260 underdog this week against #24 Utah. The Bearcats must win to keep pace with BYU (8-0) at the top of the Big 12 rankings. Cincinnati will win its eighth consecutive game with an upset over a Utes team that is 1-2 against ranked teams this season.
Top Week 10 College Football Prop Bets
#1 Ohio State needs an impressive win this week to remain at the top of the AP rankings. The Buckeyes should put on a show against rival Penn State, beating the Nittany Lions by at least 11.5 in the first half.
The team trying to catch the Buckeyes is #2 Indiana, which is ranked ahead of Ohio State in the Big Ten standings. Indiana faces an unranked Maryland team that is 1-3 in conference play. The Hoosiers average 45.4 PPG, third-most in the country, and they will cover this alternate spread of 23.5 points this week.
The #7 Rebels take on a struggling South Carolina team that has dropped five of its six conference games. Ole Miss will win, and their offense should score early and often. I believe the Rebels will score over 16.5 points in the first half against the Gamecocks.
Betting on College Football in Week 10
Using the best NCAAF betting sites is the most convenient way to wager on your college football predictions this weekend. There are betting markets for every ranked team taking the field this week, including my favorite wager: #13 Texas Tech (-285) to beat K-State.
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