NFL Picks for Week 14 (2025)

Every NFL pick in Week 14 could shake up the playoff race as the regular season winds down. The cold weather will also undoubtedly affect post-Thanksgiving football. 

Keep reading to see my NFL predictions for every Week 14. I break down my top moneyline, spread, and upset bets of the week, starting with Thursday night’s clash between the Cowboys and the Lions in Detroit. 

Latest Week 14 NFL Odds

Here are the latest odds for your NFL Week 14 picks, courtesy of Lucky Rebel.     

The Lions and the Cowboys meet on TNF this week after very different performances on Thanksgiving. Detroit lost to Green Bay, while the Cowboys pulled off a major upset of the visiting Chiefs. The Lions are 3.0-point home favorites this week. 

Sunday’s 12-game slate includes several important matchups. One of the most consequential games pits the Bengals against the Bills in Buffalo. The Bills are favored by 6.0 points against Joe Burrow and company. 

The Sunday Night Football matchup also carries major playoff implications as the Chiefs (6-6) host the Texans (7-5). KC is a 3.5-point home favorite against the visiting Texans in this battle of playoff hopeful teams. 

For the latest odds and best lines for Week 14, check out Lucky Rebel. Read our Lucky Rebel review to learn more about this highly-rated football betting site.  

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Week 14 TNF Best Bet: Dallas Cowboys (+147)

• Amon-Ra St. Brown, dealing with a low ankle sprain, could miss this game. St. Brown leads the Lions in receptions and receiving yards, and his absence would hinder Detroit’s offense.
• Dallas’s run defense has held two of its last three opponents under 70 total rushing yards.
• The Cowboys’ explosive offense leads the NFL with 393.1 YPG, including a league-high 271.3 passing YPG.

Detroit’s 31-24 loss on Thanksgiving was costly in a variety of ways. First and foremost, it put the Lions’ playoff hopes in jeopardy. Amon-Ra St. Brown, the team’s leading receiver, was hurt early in the loss, exiting the game with a low-ankle sprain. 

Without St. Brown, the Lions’ offense struggled to finish drives, especially in the second half. Detroit is favored at home again this week, but if St. Brown is sidelined, the offense will struggle to keep up with the Cowboys. 

Dallas’s offense puts up more yards than any other team, averaging over 390 YPG. The Cowboys have won three straight games, including beating the Eagles and Chiefs in back-to-back games. 

Stopping the Cowboys’ offense will be easier said than done for a Lions’ defense that is struggling with injuries once again this season. Dallas also has a stout run defense, which they will need to slow down Jahmyr Gibbs and David Montgomery. 

The Cowboys should be able to focus on stopping the run if St. Brown is out. With that in mind, I think Dallas can secure the upset as a +147 underdog this Thursday. 

Week 14 NFL Picks 

Here are my NFL Week 14 predictions available at the top NFL betting sites.  

Best Week 14 NFL ML Picks (Straight Up)

• Baltimore Ravens (-280) – Bet now!
• Cleveland Browns (-214) – Bet now!
• Kansas City Chiefs (-202) – Bet now!

Kicking off my best moneyline NFL picks for Week 14 are the Ravens, who are -280 favorites at home this week against Pittsburgh. The Steelers’ defense is a shell of its former self, and their offense is somehow worse. Baltimore will bounce back with a win this week, taking firm control of the AFC North. 

Speaking of the North, Cleveland lost at home as underdogs in Week 13 against the visiting 49ers. The Browns face an easier matchup this week against the visiting Titans. Myles Garrett and the defense will win Cleveland this game, and Garrett could break the sack record against a Titans team that has already allowed 48 sacks this season, most in the league. 

On SNF, the Chiefs host the Texans in a game that could end the loser’s playoff hopes. Houston’s defense is arguably the best in the league, but Patrick Mahomes and Andy Reid will have a plan to beat them. KC wins, keeping their thin hopes of making the postseason alive.

Week 14 NFL Picks ATS

• Cincinnati Bengals +6.0 (-110) – Bet now!
• Seattle Seahawks -7.0 (-114) – Bet now!
• Philadelphia Eagles -3.0 (-102) – Bet now!

The Bengals upset the Ravens on Thanksgiving in Joe Burrow’s return to action. Burrow and Cincinnati are 6.0-point underdogs against the Bills this Sunday at Orchard Park. Cincy’s explosive offense will help them cover the spread in a game that is a must-win for both teams. 

Seattle’s defense led the way in their 26-0 win over the Vikings on Sunday. The Seahawks’ offense struggled, but Sam Darnold and Co. should have an easier time moving the ball against the Falcons this week. Seattle will cover the 7.0-point spread against an Atlanta defense that could not slow down the Jets last week. 

Philadelphia lost on Black Friday to the Bears, giving the Eagles their second two-game losing streak of the season. Jalen Hurts and the Eagles will right the ship this week as 3.0-point favorites against the Chargers on MNF. Philadelphia’s defensive line should dominate a Chargers’ team missing multiple starting linemen, especially if Justin Herbert’s broken hand keeps him from starting this week.

Best Week 14 NFL Upset Picks

• Jacksonville Jaguars (+106) – Bet now!
• New York Jets (+122) – Bet now!
• Chicago Bears (+250) – Bet now!

The Colts have lost three of their last four games, and their losing streak cost them the AFC South division lead. Indianapolis is favored to regain the division lead this week by beating the Jaguars in Jacksonville. However, the Colts have not won in Jacksonville in over a decade, and the Jags aggressive defense will help them secure the +106 upset over a stumbling Indy team this week. 

New York shocked Atlanta last week, upsetting the visiting Falcons 27-24. The Jets are underdogs at home again this week, listed at +122 against Miami. New York almost beat the Dolphins in their Week 4 matchup, and Tua Tagovailoa’s inability to win games in the cold will help the Jets win the rematch this weekend. 

Chicago is currently the top seed in the NFC after beating the Eagles on Black Friday. Despite their 9-3 record, though, the Bears are +250 underdogs this week against the Packers in Green Bay. The Bears’ dominant running game will help them slow the Packers’ pass rush, enabling Chicago to pull off the upset win over its divisional rival.

NFL Week 14 Predictions

Jayden Daniels’ potential return has the Commanders are -135 road favorites over the Vikings this weekend. Even if Daniels cannot go, Washington is in a great spot to end its seven-game losing streak. Minnesota’s struggling offense will cost the Vikings another chance at victory this Sunday. 

Denver extended its winning streak to nine games with its OT win over the Commanders on SNF. Now, the Broncos are -435 favorites to get a 10th straight win with a road date against the Raiders on Sunday. Denver’s top-three defense will demolish Las Vegas this week, moving the Broncos into the top seed in the AFC. 

The Los Angeles Rams lost in Carolina last week, and Matthew Stafford’s record-setting streak of TD passes without an interception came to an end. LA is listed at -385 to bounce back this week with a win against the lowly Cardinals. This divisional matchup could be closer than anticipated, but LA will escape Glendale with a win. 

Where to Make Your Week 14 NFL Picks

Lucky Rebel is the top place to wager on your NFL picks in Week 14. You can bet on every game this week, including my favorite wager: Kansas City Chiefs (-202) to beat the Houston Texans. 

Creating your Lucky Rebel account is easy to do, and it allows you to bet on your favorite moneyline, upsets, and NFL picks against the spread this week. New members can claim a 125% welcome bonus to gain up to $1,250 in bonus funds for Week 14.