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UKNFL Picks for Week 10 (2025)
Our NFL picks for Week 10 are the perfect tool for kicking off the second half of the NFL season. The first week of the back nine of the 2025 season includes multiple divisional matchups and a cross-conference game in Berlin.
Keep reading to see the latest betting lines and our NFL predictions for every Week 10 game. I also highlight my favorite bets of the week, breaking down why each wager deserves a spot on your betting ticket this Sunday.
Latest Week 10 NFL Odds
Here are the latest Week 10 betting odds, provided by Lucky Rebel.
| Matchup | Moneyline | Point Spread |
|---|---|---|
| Las Vegas Raiders vs. Denver Broncos | Raiders (+365)Broncos (-500) | Raiders +8.0 (-105)Broncos -8.0 (-115) |
| Atlanta Falcons vs. Indianapolis Colts | Falcons (+205)Colts (-265) | Falcons +5.5 (-111)Colts -5.5 (-110) |
| New Orleans Saints vs. Carolina Panthers | Saints (+200)Panthers (-255) | Saints +5.0 (-108)Panthers -5.0 (-113) |
| New York Giants vs. Chicago Bears | Giants (+161)Bears (-198) | Giants +3.5 (-109)Bears -3.5 (-111) |
| Jacksonville Jaguars vs. Houston Texans | Jaguars (+103)Texans (-124) | Jaguars +1.5 (-112)Texans -1.5 (-109) |
| Buffalo Bills vs. Miami Dolphins | Bills (-550)Dolphins (+395) | Bills -10.0 (-108)Dolphins +10.0 (-113) |
| Baltimore Ravens vs. Minnesota Vikings | Ravens (-220)Vikings (+178) | Ravens -4.0 (-110)Vikings +4.0 (-110) |
| Cleveland Browns vs. New York Jets | Browns (+110)Jets (-133) | Browns +2.0 (-112)Jets -2.0 (-109) |
| New England Patriots vs. Tampa Bay Buccaneers | Patriots (+127)Buccaneers (-155) | Patriots +2.5 (-102)Buccaneers -2.5 (-119) |
| Los Angeles Rams vs. San Francisco 49ers | Rams (-192)49ers (+156) | Rams -3.5 (-105)49ers +3.5 (-116) |
| Detroit Lions vs. Washington Commanders | Lions (-450)Commanders (+330) | Lions -9.0 (-109)Commanders +9.0 (-112) |
| Pittsburgh Steelers vs. Los Angeles Chargers | Steelers (+133)Chargers (-162) | Steelers +3.0 (-114)Chargers -3.0 (-106) |
| Philadelphia Eagles vs. Green Bay Packers | Eagles (+121)Packers (-147) | Eagles -1.5 (+132)Packers +1.5 (-160) |
The Bills (-10.0) and Lions (-9.0) are the only teams laying multiple scores this weekend. Buffalo is coming off a huge win over the Chiefs, while Detroit is looking to bounce back after a disappointing loss against Minnesota.
Week 10 features multiple divisional matchups, including Raiders vs. Broncos, Saints vs. Panthers, Jaguars vs. Texans, Bills vs. Dolphins, Cardinals vs. Seahawks, and Rams vs. 49ers.
As with last week, there are four teams on a bye in Week 10. The teams off this week are Tennessee, Kansas City, Dallas, and Cincinnati.
View the latest odds and bet on your picks at Lucky Rebel. You can also read our Lucky Rebel review to find out more about this highly regarded sportsbook.
Week 10 NFL Picks
Let’s take a closer look at my favorite NFL Week 10 bets available at the top NFL betting sites.
Best Week 10 NFL ML Picks (Straight Up)
Carolina did more than just cover their +13.0 Week 9 odds when the Panthers upset the Packers and won outright. Now, Bryce Young and company are -255 favorites over the Saints this weekend. Carolina’s running game will carry the Panthers to their fourth home win of the season.
Another favorite to bet on this week is Tampa Bay, which is listed at -155 against New England. Both teams have just two losses, but the Buccaneers had a bye last week to prepare for the visiting Patriots. New England has won six straight and is 4-0 on the road, but their luck runs out this week in what should be a shootout in Tampa Bay.
The Rams (6-2) dominated the Saints last week, cruising to a 34-10 home win. Los Angeles hits the road this week against San Francisco (6-3) in a must-win game for both teams. The 49ers won the first matchup, but they have lost multiple starters since then, and LA will get its revenge this weekend.
Week 10 NFL Picks ATS
Atlanta nearly pulled off the upset over New England last week thanks to Drake London’s three TD performance. They head to Berlin this Sunday to take on a Colts (7-2) team that also lost on the road on Sunday. International games can be challenging to predict, but I expect the Falcons’ offense to build on their momentum from Sunday and keep the game within 5.5 points.
Miami is also an underdog this week, getting 10.0 points against the visiting Bills. Buffalo beat the Dolphins in their first matchup, and the Bills are coming off their regular-season Super Bowl, a win over KC. This has the makings of a classic trap game for the Bills, and Miami will keep the score within single digits.
Detroit is laying 9.0 points this week as road favorites against the Commanders. The Lions need a major win to get the taste of last week’s loss out of their mouths. Washington, on the other hand, lost multiple starters in their MNF loss, including QB Jayden Daniels, and will lose by at least 10 in this NFC Divisional Road rematch on Sunday.
Best Week 10 NFL Upset Picks
J.J. McCarthy led Minnesota to an upset win over the rival Lions last week. McCarthy and the Vikings are +178 underdogs at home against the Ravens in Week 10. Baltimore’s defense will be tested this week, and I believe the Vikes will have a game plan to exploit the Ravens’ weaknesses and secure another upset win.
Cleveland (2-6) is a +110 underdog against the Jets (1-7) this Sunday. Both teams had a bye last Sunday, giving New York extra time to celebrate its first win of the season. The Browns’ offense is bad, but their defense has been outstanding at times and will be the reason Cleveland wins on the road this week.
Pittsburgh shocked the Colts last week, taking a 24-7 fourth-quarter lead and earning a win over the number one seed. The Steelers are +133 underdogs this week against the Chargers in LA. Los Angeles’s injury-depleted offensive line will not be able to stop Pittsburgh’s pass rush this week, and the Steelers will get another upset win this Sunday.
NFL Week 10 Predictions
Denver (7-2) looks to maintain its lead in the AFC West with a crucial TNF matchup against the Raiders (2-6). Neither team has a win in the division yet this season, but the Broncos should change that this week. Las Vegas lost in OT last week, giving them even less time to prepare on a short week against a team that is simply better than them.
Chicago’s defense has no-showed two weeks in a row, but Caleb Williams and company did enough last week to beat Cincinnati 47-42. The Bears should have an easy time taking down the Giants this week, especially since New York is without its best offensive skill players in Malik Nabers and Cam Skattebo.
Houston’s offense failed to deliver again last week, and the Texans lost at home 18-15 against Denver. CJ Stroud also entered concussion protocol and could miss this week’s AFC South showdown against the Jags. If Stroud is out, then the Jags should secure the win on Sunday.
Where to Make Your Week 10 NFL Picks
Lucky Rebel is the best place to wager on your NFL picks for every Week 10 game. It offers competitive betting lines on every game, including this Sunday’s early morning kickoff in Berlin. My top bet of the week at Lucky Rebel is Carolina (-255) to beat New Orleans.
Shop the latest lines and wager on your picks at Lucky Rebel today using bonus funds. New members who claim the 125% welcome promotion package can get 100 free spins and up to $1,250 in extra funds for betting on Week 10.
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