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UKWeek 6 College Football Picks (2025)
Eight ranked teams are on byes, but there are still plenty of exciting games for your college football picks this week.
This guide analyzes the latest odds for every game featuring a ranked team in Week 6. I will break down the current betting lines and highlight my favorite bets of the week.
Week 6 College Football Odds (Top 25)
Check out the table below for Lucky Rebel’s odds for every ranked team in Week 6.
| Matchup | Favorite | Underdog | Point Spread |
|---|---|---|---|
| West Virginia vs. #23 BYU | #23 BYU (-1200) | West Virginia (+675) | #23 BYU -19.0 (-108) |
| Kentucky vs. #12 Georgia | #12 Georgia (-1600) | Kentucky (+825) | #12 Georgia -20.5 (-113) |
| #14 Iowa State vs. Cincinnati | Cincinnati (-124) | #14 Iowa State (+102) | Cincinnati -1.5 (-111) |
| Wisconsin vs. #20 Michigan | #20 Michigan (-900) | Wisconsin (+575) | #20 Michigan -17.0 (-113) |
| #22 Illinois vs. Purdue | #22 Illinois (-380) | Purdue (+290) | #22 Illinois -9.5 (-115) |
| #7 Penn State vs. UCLA | #7 Penn State (-3300) | UCLA (+1200) | #7 Penn State -25.0 (-112) |
| #9 Texas vs. Florida | #9 Texas (-255) | Florida (+200) | #9 Texas -6.5 (-119) |
| #16 Vanderbilt vs. #10 Alabama | #10 Alabama (-435) | #16 Vanderbilt (+325) | #10 Alabama -10.5 (-108) |
| Boise State vs. #21 Notre Dame | #21 Notre Dame (-1200) | Boise State (+700) | #21 Notre Dame -20.5 (-111) |
| #24 Virginia vs. Louisville | Louisville (-255) | #24 Virginia (+200) | Louisville -7.0 (-118) |
| Kent State vs. #5 Oklahoma | #5 Oklahoma | Kent State | #5 Oklahoma -45.5 (-111) |
| #11 Texas Tech vs. Houston | #11 Texas Tech (-475) | Houston (+350) | #11 Texas Tech -11.5 (-108) |
| Minnesota vs. #1 Ohio State | #1 Ohio State (-2800) | Minnesota (+1100) | #1 Ohio State -24.0 (-111) |
| #3 Miami vs. #18 Florida State | #3 Miami (-188) | #18 Florida State (+153) | #3 Miami -4.0 (-115) |
| Mississippi State vs. #6 Texas A&M | #6 Texas A&M (-625) | Mississippi State (+440) | #6 Texas A&M -14.5 (-103) |
Oklahoma moved up to #5 in the latest rankings, and the Sooners are the biggest favorite of the weekend at -45.5. #1 Ohio State, #12 Georgia, and #21 Notre Dame are also laying 20+ points in the latest NCAAF Week 6 odds.
Only two ranked teams, #14 Iowa State and #24 Virginia, are underdogs to unranked teams this week.
Eight of the AP Top 25 teams are off this weekend, including:
- #2 Oregon
- #4 Ole Miss
- #8 Indiana
- #13 LSU
- #15 Tennessee
- #17 Georgia Tech
- #19 Missouri
- #25 Arizona State
Read this free and unbiased Lucky Rebel review to find out more about why this sportsbook is the best place to bet on college football lines this week.
Best Week 6 College Football Picks
Here are my best bets for the first college football weekend in October.
Straight Up/ML Picks
My college football predictions for Week 6 start with #22 Illinois. The Fighting Illini bounced back in a big way last week, beating then #21 USC 34-32. Illinois (-380) will win again this week on the road against Purdue (2-2).
Another ranked team that should pick up the win this week is #9 Texas. The Longhorns are -255 favorites against Florida (1-3). The Gators fell out of the rankings after losing to South Florida in Week 2 and have since lost to LSU and Miami. Florida’s losing streak against ranked teams will continue this week against Texas.
Speaking of ranked teams from the Lone Star State, #11 Texas Tech is a -475 favorite against Houston. Both teams are undefeated heading into this Big 12 matchup. The Red Raiders, who topped #16 Utah last week and have scored at least 34 in every game, will win this matchup of high-scoring offenses.
Best ATS Picks
The Bulldogs lost once again to the Crimson Tide last week, dropping Georgia to #12 in the latest rankings. On the bright side, Georgia has a perfect punching bag to work out their frustrations on this week against Kentucky. The Bulldogs (34.5 PPG) are averaging over a touchdown more per game than the Wildcats (27.0 PPG) this year, and Georgia will cover the 20.5 points this week.
Speaking of #10 Alabama, the Crimson Tide is laying 10.5 points this week against the undefeated #16 Commodores. Alabama is coming off a huge win over its biggest rival, Georgia, and could overlook Vandy. I think Vanderbilt, which is averaging the fourth-most PPG this season (49.0), will cover +10.5.
The #1 Ohio State Buckeyes were laying single digits in the Week 5 college football odds, and cruised to a 24-6 road win. Ohio State is laying 24.0 points this week at home against unranked Minnesota (3-1). The Horseshoe will be rocking for this Big 10 matchup, and the Buckeyes will cover at home.
Top CFB Upset Picks
#14 Iowa State is a road underdog this week against unranked Cincinnati. The Bearcats are averaging 39.5 PPG this year, and while the Cyclones have put up just 31.6 PPG. However, Cincinnati has played a much lower level of competition, and Iowa State will secure the road upset this week.
The current odds also list #24 Virginia, a new entry to the rankings, as an underdog this week. They face an unbeaten, but also unranked, Louisville team on the road this week. Virginia’s high-flying offense outdueled Florida State last week, and they will keep rolling with a win in Louisville this week.
Boise State started the year ranked 25th but dropped out of the rankings after losing to USF. Since then, they are 3-0 and will now face #21 Notre Dame, which has won back-to-back games to improve to 2-2. The Fighting Irish’s struggles against good teams will return this week, and the Broncos will get the upset win in South Bend.
Top Week 6 College Football Prop Bets
Penn State, predictably, lost another big game against a top 10 team last week. The good news for Nittany Lions fans is that PSU faces an unranked UCLA team in Week 6. They are 25.0-point favorites, but I think Penn State can cover an alternate spread of -27.0 (+105)
The 5th-ranked Sooners are also heavy favorites this weekend, laying 45.5. Oklahoma should get out to an early lead, and I believe they will cover -29.5 in the first half against Kent State.
One of the biggest matchups of the weekend pits #3 Miami against #1 Florida State. This battle for bragging rights in the Sunshine State should be one of the most entertaining games of the weekend. I think Miami’s Mark Fletcher, who has five TDs this year, will score at least once (-200) against the Seminoles.
Betting on College Football in Week 6
The top NCAAF sportsbooks make betting on your college football picks fun and easy. Check out the guide above to see the latest Week 6 college football odds and my best bets, such as #16 Vanderbilt +10.5 (-112) against #10 Alabama.
Lucky Rebel is the best sportsbook for wagering on your college football picks this weekend. New members who claim the 125% welcome bonus can get up to $1,250 in extra funds for betting on this week’s games.
