Wednesday’s MLB Predictions and Betting Tips – April 21, 2021

| April 21, 2021 4:16 am PDT

The Dodgers and Mariners get the day off after battling each other on Tuesday afternoon. I bring this up because every other team in the league is in action on Wednesday. The Pirates and Tigers will play a double-dipper in Detroit after last night’s game was snowed out, bringing the total to 15 games on the day.

  • San Francisco Giants vs. Philadelphia Phillies – 1:05 PM ET
  • Baltimore Orioles vs. Miami Marlins – 1:10 PM ET
  • Pittsburgh Pirates vs. Detroit Tigers (GM 1) – 2:10 PM ET
  • Houston Astros vs. Colorado Rockies – 3:10 PM ET
  • Minnesota Twins vs. Oakland Athletics – 3:37 PM ET
  • Louis Cardinals vs. Washington Nationals – 4:05 PM ET
  • Texas Rangers vs. Los Angeles Angels – 4:07 PM ET
  • Milwaukee Brewers vs. San Diego Padres – 4:10 PM ET
  • Chicago White Sox vs. Cleveland Indians – 6:10 PM ET
  • Atlanta Braves vs. New York Yankees – 6:30 PM ET
  • Arizona Diamondbacks vs. Cincinnati Reds – 6:40 PM ET
  • Pittsburgh Pirates vs. Detroit Tigers (GM 2) – 6:40 PM ET
  • Toronto Blue Jays vs. Boston Red Sox – 7:10 PM ET
  • New York Mets vs. Chicago Cubs – 7:40 PM ET
  • Tampa Bay Rays vs. Kansas City Royals – 8:10 PM ET

Let’s jump right into some MLB predictions for Wednesday.

MLB Game Winner Predictions for April 21st

  • Giants to beat the Phillies
  • White Sox to beat the Indians
  • Marlins to beat the Orioles
  • Braves to beat the Yankees
  • Tigers to beat the Pirates (GM 1)
  • Reds to beat the Diamondbacks
  • Rockies to beat the Astros
  • Pirates to beat the Tigers (GM 2)
  • Athletics to beat the Twins
  • Red Sox to beat the Blue Jays
  • Nationals to beat the Cardinals
  • Cubs to beat the Mets
  • Angels to beat the Rangers
  • Royals to beat the Rays
  • Padres to beat the Brewers

No fluff or justification here – just straight up MLB picks for April 21st. However, I wouldn’t advise you getting money down on all 15 games just so you can say you “covered your bases.” The better plan is to carefully pinpoint the games that you can spot an edge in.

That could mean spotting a discrepancy in the price or having a difference of opinion in a pitching matchup. There are all sorts of ways to extract value, including targeting the plus-money dogs.

Top MLB Upset Picks for April 21st  

  • Rockies +134 (over the Astros)
  • Athletics +100 (over the Twins)
  • Braves +107 (over the Yankees)

Anytime you can latch onto a home team at +134 to win a baseball game outright, you should probably take a look. Especially when the visiting team is playing out of their league and doesn’t even have a winning record.

Austin Gomber strolls into Wednesday afternoon’s game in Coors Field on the heels of back-to-back quality starts featuring at least 95 pitches in each. Frankly, I was hoping to find the Rockies listed in the +120 range to beat the Astros – I was delighted to see one of the best MLB betting sites install Colorado at +134.

Nabbing Oakland at even money is not only one of my top MLB picks on Wednesday, it’s what I call a “green-light special.”

Let’s start with the fact that the A’s have a better record than the Twins, they’re playing at home, and Kenta Maeda is no longer “unhittable” like he was for the bulk of 2020.

Maeda, Minnesota’s starting pitcher on Wednesday, has surrendered 20 hits through his first three starts of the year. The 33-year-old right-hander didn’t allow his 20th hit until his 7th start a season ago.

The Athletics are as hot as any team in the league – passing on them as a home underdog versus the Twins wouldn’t make any sense.

Rounding out my MLB upset picks on April 21st is the Atlanta Braves going into New York and knocking off the Yanks. Corey Kluber has failed to pitch into the fifth inning in all three of his starts since he started donning the Pinstripes, not to mention, the Yankee bats have been failing as of late. Going into Tuesday’s contest, New York had gone six straight games scoring four or fewer runs.

While Kluber is a man way past his prime, Ian Anderson has filthy stuff and is one of the true up-and-comers.

And let’s not forget that the Braves lead the Majors in home runs – in large part thanks to Ronald Acuna Jr. playing like a man possessed.

Best MLB Bets for Wednesday, April 21st

  • Reds over the Diamondbacks (-180)
  • Nationals over the Cardinals (-184)
  • Brewers vs. Padres Over 7 Runs (-125)

Transitioning into the best MLB bets today, I circled the matchup in Cincinnati ever since Tyle Mahle was penciled in to take the hill. The hard-throwing righty is off to a fantastic start through his first three appearances and has made adjustments after tipping his pitches in his last start.

Tyle Mahle – Pitching Game Log in 2021
Date Opponent Innings Hits Earned Runs


Pitch Count
4/14 Giants 5.0 3 2


4/9 Diamondbacks 4.0 0 0


4/3 Cardinals 5.1 4 2



Worth noting – Mahle didn’t allow a single hit 12 days ago against the D-Backs lineup.

I’ll keep my thoughts regarding the Cardinals vs. Nationals game short and sweet because -184 seems like a sweet bargain in this spot. Carlos Martinez is sporting a 7.80 ERA and is 0-3 on the season. The Redbirds have been outscored by a total of 30-8 in the three games Martinez has started.

It’s unlikely Carlos’ luck turns on Wednesday in D.C. against a surging Max Scherzer.

“Mad Max” looked brilliant last time out tossing seven scoreless innings while striking out 10 and yielding just two hits.

Anything under -200 on the Nats seems more than reasonable.

In the mood to switch things up and go after a total?

Look no further than the over at Petco Park. San Diego’s offense has been lackluster thus far, but seven runs in awfully low in a game that’ll likely require Jayce Tingler to turn to his bullpen early. Dinelson Lamet is making his first start of the season (elbow) and will almost certainly be on a strict pitch count.

Michael Wynn
Michael Wynn

As a former Division I collegiate golfer, Michael Wynn loves writing about golf. He's also an expert in most of America's most popular sports, writing extensively for on football, basketball, and baseball.

Michael's a Las Vegas native and has been with the company since 2017.

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