Thursday’s MLB Predictions and Betting Tips (May 6, 2021)

| May 6, 2021 2:20 am PDT

Gerrit Cole faces his former team at Yankee Stadium in front of a restless New York fan base. Brandon Woodruff and Zack Wheeler are set to clash in Philadelphia.

Not bad for the two 1:05 PM ET matchups that kick off Thursday’s 10-game slate.

I’ve made predictions for all 10 of the games in the section below. You’ll find my best MLB picks of the day in the following two segments.

MLB Game Winner Predictions for May 6th

  • Yankees beat the Astros
  • Brewers to beat the Phillies
  • Red Sox to beat the Tigers
  • Twins to beat the Rangers
  • Cardinals to beat the Mets
  • Royals to beat the Indians
  • Blue Jays to beat the Athletics
  • Nationals to beat the Braves
  • Diamondbacks to beat the Marlins
  • Rays to beat the Angels

*Stats referenced are through Tuesday

One way to get roped into betting baseball online is to check out the prop builders. It helps you stay inclined to follow the action, not to mention, a few bucks can turn into thousands.

One of my MLB predictions for Thursday that almost goes without saying is that the Red Sox beat the Tigers at Fenway Park. Boston is scoring a chunk of runs (4.97/game), and the Tigers are playing substantially worse than anyone else in the league.

I’m just a bit hesitant to cough up -208 in a game with so many variables. Nathan Eovaldi has been solid thus far, but he’s not quite “ace material.”

As for the games I’m ready to endorse, here’s a four-pack to explore.

Top MLB Upset Picks for May 6th

  • Cardinals +106 (over the Mets)
  • Diamondbacks +125 (over the Marlins)

I made sure to hop on the Redbirds at home before the “plus-money” vanishes. The Mets are 3-6 as a road favorite and just 7-10 as a favorite overall. It’s hard to trust Taijuan Walker after he gave up four runs in his last start.

On the flip side, Cardinals starter Jon Gant has become a fixture in the rotation, having surrendered a total of three runs across his last three starts. Nolan Arenado is starting to heat up, slashing .333/400/.704 over his last seven games.

To get a better glimpse at which of these clubs is playing better baseball in 2021, check out the table below.

Run Differential in 2021
Runs Scored Runs Against +/-
Cardinals 138 118 +20
Mets 76 89 -13

I’ve penciled St. Louis in as one of my MLB underdog picks. I also latched onto the D-Backs at +125 in Miami.

Madison Bumgarner backed up his seven-inning no-no with another sparkling performance last Friday. Over his last three outings, “MadBum” has relinquished just six hits and two runs in 17 innings. Amassing 18 Ks compared to just two walks during that stretch tells me things are starting to click for the 3x World Series champ.

As long as Bumgarner can at least match what Pablo Lopez brings to the table, the Diamondbacks bats should be able to take over from there.

Batting Stats in 2021 (Through 5/3)
Games Home Runs Runs Scored BA OBP SLG
Diamondbacks 29 40 153 .240 .322 .423
Marlins 28 25 116 .230 .307 .365

Best MLB Bets for Thursday, May 6th 

  • Brewers over the Phillies (-110)
  • Yankees over the Astros (-190)

I’ve heard some touts say that Brandon Woodruff is evolving into one of the premier pitchers in baseball.


What more does this guy have to do to arrive?

After pitching well in 2018 and 2019, Woodruff was sensational in 2020. He’s been downright dominant in 2021.

The 28-year-old right-hander has given up just one homer in six starts; only Jacob deGrom has a lower ERA among qualified NL starters. His sinker runs 96-97 mph, and his curveball is straight nasty.

I like the Phillies and believe in Zack Wheeler, but Woodruff isn’t getting the respect he deserves. Frankly, I’d lay -125 on Milwaukee and not even bat an eye.

Talk about dominant pitchers in 2021; Gerrit Cole has caught fire over his last five starts. And I mean that wholeheartedly. The way the fans in the Big Apple will be laying into the Astros batters every time they step to the dish, it’s unlikely Houston will be able to douse the flames.

62 strikeouts in 37.2 innings allude to Cole’s superiority, but here’s what catches my eye about what the $324 million man has been up to.

Gerrit Cole in 2021 – An Absurd K/BB Ratio
Date Opponent Strikeouts Walks
4/30 Tigers 12 0
4/24 Indians 11 0
4/18 Rays 10 0
4/12 Blue Jays 8 1
4/6 Orioles 13 0
4/1 Blue Jays 8 2

That’s 33Ks and 0 walks over his last three starts, or 54 Ks and 1 walk over his last five.

Are you still giving pause about laying -190 in a game that Cole is on the bump? If you’re not backing the Yanks as one of your MLB picks on May 6th, you ought to rethink your process.

Michael Wynn
Michael Wynn

As a former Division I collegiate golfer, Michael Wynn loves writing about golf. He's also an expert in most of America's most popular sports, writing extensively for on football, basketball, and baseball.

Michael's a Las Vegas native and has been with the company since 2017.

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