San Francisco 49ers vs. Philadelphia Eagles Pick – NFL, Week 2 (2021)

| September 17, 2021 9:29 am PDT

It wasn’t pretty, but San Francisco left Ford Field with a victory. Mission accomplished. Unfortunately, Kyle Shanahan’s group did not emerge completely unscathed. Jason Verrett tore his ACL, and Raheem Mostert busted his knee; both have been ruled out for the rest of the year.

On the other hand, Philadelphia couldn’t have drawn up a better start. Jalen Hurts was outstanding, and the defense stayed disciplined. The cherry on top is, the rest of the NFC East went winless.

Was the Eagles’ week 1 result a fluke, or is this a much-improved bunch that’s a sincere threat to win their division?

We’ll know a lot more about the Eagles after they clash with San Fran on Sunday. Let’s peer ahead to the action and work our way toward a 49ers vs. Eagles pick.

49ers vs. Eagles Odds

49ers (-3.5)-110
Eagles (+3.5)-110
49ers to Win-195
Eagles to Win+165
Over 50-110
Under 50-110

The latest odds for the 49ers vs. Eagles game remain consistent with the opening number. What’s changed drastically is the total, ballooning all the way from 45 to 50 in the span of a couple of days.

The explanation for this development is simple. San Francisco moved the ball up and down the field at will and scored 41 points in week 1. Likewise, Philly was making plays left and right as they lit the Falcons up for 32. Bettors flocking to the best NFL sportsbooks online can’t help but be influenced by what just transpired.

Those hoping to glean any betting tips from last year’s against the spread (ATS) data, here are few talking points worth bringing up.

  • The 49ers were 2-6 ATS as a favorite in 2020
  • The 49ers were 2-4 ATS at home in 2020
  • The 49ers were 0-3 ATS at home favorites in 2020

Philly did go 1-4 against the spread on the road as an underdog, but I’m less concerned with what the Eagles did under the direction of Doug Pederson. Just one game in, and Nick Sirianni already looks much more competent.

49ers Preview

Kyle Shanahan will have had plenty to harp about this week in practice. The Lions had the ball late in the fourth quarter with a chance to send the game into overtime. On the flip side, there are lots of positives the Niners head honcho can take away from week 1.

Other than bobbling his opening snap, Jimmy Garoppolo performed favorably. He got the ball out when he needed to (only sacked once) and took advantage of mismatches when they presented themselves. Talk of Trey Sermon being a healthy scratch and Brandon Aiyuk being demoted quickly faded away thanks to splendid showings from Elijah Mitchell and Deebo Samuel.

Shanahan even singled out Mitchell’s play after the game – kudos to those of you who scooped the former Ragin’ Cajun off your waiver wire this week.

“I thought he did a real good job. That’s kind of what we expected him to do. But it’s always tough in your first game and stuff. He went in there and didn’t hesitate and ran the ball well.”

Expect to see a small dose of Trey Lance, but it’ll be Jimmy G peppering George Kittle this Sunday in Philadelphia.

Eagles Preview

The Eagles looked lost on offense in 2020, averaging just 5.0 yards per play (T-28th in the NFL). After boasting a rock-solid 6.5 yards per play on Sunday (same as the Chiefs), there’s reason to be excited if you root for the Iggles.

Those who studied Philly this offseason knew that Hurts would be lively with his feet. It was clear that his arrival added a new dimension to this offense. What wasn’t predicted was that Jalen would make massive strides as a thrower right from the get-go.

Just how sharp was Hurts in Philadelphia’s week 1 triumph?

According to PFF, Hurts was the second-highest graded QB in the first week. Only Tom Brady was better.

Jalen Hurts – By the Numbers in Week 1
Completions/Attempts Passing Yards Passing Touchdowns Interceptions Quarterback Rating
27/35 (77.1%) 264 3 0 126.4

Throw in his 62 rushing yards on seven totes, and the second-year signal-caller had himself one heck of a day.

Transitioning to the other side of the ball, first-year defensive coordinator Jonathan Gannon made his mark. The Eagles held the Falcons to 3-14 on third down and yielded a measly 4.1 yards per play. Matt Ryan’s 17.6 QBR was his lowest since October of 2019.

Philly’s front seven will have a harder time penetrating the 49ers’ offensive line, which is why I’ll be keeping a close eye on the battle in the trenches. The team that wins that war up front is the team likely to head into week 3 with a 2-0 record.

49ers vs. Eagles Prediction

With Raheem Mostert, no longer part of the Niners game plan, more of an onus is placed on Jimmy G and the passing attack. Against a tame defense like Detroit’s, that’s all fine and dandy. Against Philly, not so much.

The Eagles D was wreaking havoc in Atlanta’s backfield all afternoon in week 1. Matt Ryan never got comfortable, and the Eagles continued to pile it on. Looking ahead to week 2, the motors on Philly’s D get an added boost thanks to playing at home.

The fans in Lincoln Financial Field will be rocking, and I love the dynamic that Jalen Hurts brings to the table. I see this game as a virtual toss-up, as do the brains behind ESPN’s NFL matchup predictor.

If you’re betting on a “straight-up” 49ers vs. Eagles prediction, I suggest siding with the home team. For what it’s worth, underdogs went 9-6 straight up in week 1.

49ers vs. Eagles Pick

Not only did the underdogs win more games than they lost last week, but backing the dogs in week 1 proved to be a terrific betting strategy (Underdogs went 12-4 ATS in week 1). Staying on that theme, my 49ers vs. Eagles betting pick is to snatch the 3.5-point line being offered at BetUS.

I pegged Philly to win this game, and the +165 number is certainly alluring. With that being said, we’re not just getting a field goal worth of insurance if we choose to attack the spread. BetUS and the other top sites have included the “hook” at no additional cost.

Sign me up.

  • Eagles (+3.5)
Michael Wynn
Michael Wynn

As a former Division I collegiate golfer, Michael Wynn loves writing about golf. He's also an expert in most of America's most popular sports, writing extensively for on football, basketball, and baseball.

Michael's a Las Vegas native and has been with the company since 2017.

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