San Francisco 49ers vs. New Orleans Saints Betting – NFL Week 10, 2020

The banged-up San Francisco 49ers head to Mercedes-Benz Superdome in New Orleans on Sunday, November 15, to take on the in-form Saints as the 2020 NFL season goes on with Week 10.

The Niners are 4-5, but their injuries are a much bigger problem than their record, so the reigning vice-champs are already in dire straits.

However, they’ll try everything they can to upset the odds Sunday with the kick-off at 4:25 PM ET, so I bring you the latest odds update along with my best 49ers vs. Saints betting pick.

The 49ers cannot count on a bunch of players due to injuries including QB Jimmy Garoppolo, TE George Kittle, and RB Raheem Mostert. Last week, the Niners missed their entire receiving corps due to a COVID-19 along with the starting LT Trent Williams, but some of the guys should return Sunday against the Saints.

Still, the 49ers are massive dogs in this one, as the Saints’ injury chart is getting cleaner, while New Orleans is riding a five-game win streak.

The Niners stood no chance in a 34-17 defeat to the Green Bay Packers last Thursday. Richie James was their only available wideout, and the seventh-round pick from the 2018 draft delivered nine receptions for 184 yards and a TD, but the Packers’ mighty offense was too much.

As well as their offense, the Niners’ defensive unit is banged up and misses a lot of important players. San Francisco is still allowing just 23.0 points per game (10^th in the NFL) on 324.7 total yards (7^th), but the Niners struggle to keep pace with the top-tier teams.

Before that heavy loss in Week 9, the 49ers suffered a 37-27 defeat at the Seattle Seahawks while scoring 20 points in garbage time. Wideouts Brandon Aiyuk and Deebo Samuel should play against the Saints, but Nick Mullens remains under center, and his decision-making has been questionable thus far.

The Saints humiliated the Tampa Bay Buccaneers this past Sunday Night Football. I bet you haven’t seen such a game in a while. The final score was 38-3, and the Saints made Tampa’s superstars look like the worst team ever.

The Bucs scored their lone field goal with 3:15 to go in the fourth quarter. They went 1-for-9 on a 3^rd down, while the Saints allowed them to record just 194 total yards. The Bucs racked up eight rushing yards, and that’s not a typo.

Furthermore, the Saints picked off Tom Brady three times. Their offense spent 40 minutes on the field, scoring five times in seven trips to the red zone. Michael Thomas returned from a six-game absence and tallied five catches for 51 yards, while Drew Brees tossed four TD passes to four different players including Emmanuel Sanders.

New Orleans is now 6-2 and sitting atop of the NFC South. The Saints are scoring 30.5 points per game (4^th in the NFL) while yielding 25.0 in a return (14^th).

Before they dismantled Tampa Bay in Week 9, the Saints have won three straight games by exactly three points, and two went to overtime. New Orleans is only 2-5 ATS in its last seven outings and just 4-9 ATS in its previous 13 games when listed as a fave of 6.5 points or more.

Still, I have to bet on the Saints to beat the 49ers by at least a touchdown. New Orleans has had some serious defensive problems so far, especially in the red zone, but their run D is working well, and that will be crucial against the Niners.

Furthermore, the Saints’ offense is finally healthy, and they’ve been doing a great job even with Michael Thomas on the shelf.

Last season, the healthy 49ers beat the Saints 48-46 in New Orleans. The Saints are only 2-4 SU and 1-1-4 ATS in their last six encounters with San Francisco which is another motive for the hosts to put on a strong performance.