Safest Bets to Target in Week 2 in the NFL (2021)

| September 15, 2021 5:36 am PDT

With Week 1 of the 2021 NFL season in the bag, it is time to look ahead to Week 2.

The season continues starting Thursday with the NFC East division matchup between the New York Giants and the Washington Football Team.

If you want to bet on that game, check out this Giants vs. Washington week two betting pick.

There is more action to be had elsewhere, though, and the goal with this NFL picks post is to nudge you toward some of the safest bets of the week.

On Sunday night, there is a great matchup between the Kansas City Chiefs and the Baltimore Ravens. Wrapping up Week 2 on Monday will be a showdown between the Detroit Lions and the Green Bay Packers.

Let’s get into the safest NFL picks for week two.

Cleveland Browns (-14) -110

This game has big blowout potential for the Browns. The Texans were one of the teams who were in the conversation for going winless this year, but they beat the Jaguars in Week 1 and put that debate to bed.

The Browns are a very solid team who can do a lot of things well. They are significantly better than the Jaguars and went round for round with the mighty Chiefs in Week 1.

Cleveland will be heavily favored in this game and are a very safe team to pick to win. The problem is how you want to approach it.

Here are the current spread and moneyline odds for the game.

  • Texans +14 (-110), Browns -14 (-110)
  • Texans (+530), Browns (-750)

Now, with how lopsided the moneyline is in favor of the Browns, you probably won’t want to bet on the moneyline. Betting $100 would have a low payout of $13.33, which is too much to put at risk.

The spread is going to be more of the money maker in this one, with (-110) odds either way.

I’m rolling with the Browns this week in a potential blowout, and taking their spread.

The Texans do not look like a competent football team and betting on their spread is extremely risky for this week.

If you aren’t willing to bet on the Browns -14 spread, consider betting on a site that lets you use alternate spreads so you can edit the spread for safer odds.

You could also take the Browns moneyline in a parlay and combine it with other safe picks for this week to increase your payout.

New England Patriots (-5.5) -120

The odds for this game are way different than the Texans and Browns game. The Patriots are currently favored (-184), with the spread +5.5 to the Jets and -5.5 to the Patriots.

My pick for this game goes to the Patriots to cover.

Young quarterbacks have trouble winning in the NFL, and Bill Belichick doesn’t make it any easier for them. Expect this one to be more of the same; the Jets’ offense behind Zach Wilson will struggle.

Ever since joining the Patriots in 2000, Bill Belichick is a whopping 21-6 against rookie NFL quarterbacks.

He also is a perfect 13-0 at home, but they will be playing this one on the road.

The only rookie quarterbacks to beat Belichick and the Patriots include Geno Smith (2013), Russell Wilson (2012), Colt McCoy (2010), Mark Sanchez (2009), and Ben Roethlisberger (2004).

Some of them had some fluky wins and weren’t a major factor in the game, but Belichick has the upper hand against the young QBs.

Zach Wilson had a slow start to his Week 1 debut, but finished with a decent stat line. The Panthers jumped to a 16-0 score at the half, which could have had Wilson throwing the ball more than planned. He finished with 258 yards and two touchdowns on 20 completions (37 attempts), adding one interception.

New England has a rookie passer of their own under center, but early reports indicate (at least arguably), he’s the best of the 2021 crop.

This rookie quarterback duel should be interesting, but the Patriots should be able to pull out a win with their superior defense.

Denver Broncos (-6.5) -105

In short, the Jaguars were horrible in Week 1.

The Texans are one of the worst teams in the league and they dominated the Jags to a 37-21 victory. The Texans don’t have a ton of talent or young guys, but they let the Jags have it in Week 1.

The Broncos should be a significantly tougher matchup for the Jaguars than the Texans were.

The Jaguars could have extra motivation this week after an embarrassing Week 1 loss, who they probably underestimated. They won’t be underestimating the Broncos after they defeated the Giants in Week 1.

The Broncos defense is their strong suit and will be a huge challenge for Trevor Lawrence in this one. Lawrence didn’t have it easy in his pro debut. Here’s his final stat line.

  • 54.9% completion rate
  • 14.2 QBR
  • 3 INT
  • 70.1 passer rating

That was against a bad Houston defense, and the Broncos secondary is light years better than the Texans. He could have another incredibly inefficient start in this one, with the Broncos defense leading the way.

The Broncos offense will be led by Teddy Bridgewater, who made big plays against the Giants in Week 1. The offense will be missing their star young receiver, after Jerry Jeudy suffered an ankle injury in their Week 1 victory.

It’s not nothing, but that shouldn’t change too much.

The Broncos are current favorites at (-260), while the Jaguars are the underdogs at (+220). The spread is also set at Broncos -6.5 and Jaguars +6.5.

The moneyline is a very safe bet for the Broncos, but I think the spread is a great bet for them, as well. I would consider taking the Broncos to cover in this one, as the Jaguars have a tough season ahead.

Green Bay Packers (-11.5) -115

Despite the Packers getting absolutely embarrassed by the Saints in Week 1, I am betting on them to turn it around this week.

Green Bay was undeniably among the biggest week one NFL losers, but they won’t stay down for long.

The Lions almost had an insurmountable comeback against the 49ers, but ultimately fell short by eight points. The 49ers are a good team, so the Lions making it interesting wasn’t super easy, but the 49ers were blowing them out earlier in the game.

Aaron Rodgers likely hasn’t been practicing a whole lot in the offseason after pondering retirement, so it wasn’t a huge surprise to see some sloppy play in Week 1. What was surprising was seeing how sloppy he was.

The Packers’ led the league in scoring in 2020 and they were held to a measly three points against the Saints.

The Saints have a tough defense and the Packers’ offense was terrible, so Week 2 will change in at least one of those categories. The Lions have a terrible defense, so it’s possible that Rodgers and the Packers get a rhythm going early.

I’m taking the Packers here in a “get right” game against the Lions on Monday Night Football.

I would lean more towards the -11.5 spread on the Packers side rather than betting on the moneyline (-590), which doesn’t look very profitable.

Betting on the NFL in Week 2

Now, safe NFL picks aren’t necessarily 100% guaranteed wins. The reason why they are considered safe is because of their very high chance to win.

They aren’t always the most profitable, of course, especially if you are sticking to moneylines.

With that being said, these teams have very high chances to win in Week 2, and they look like the best NFL bets to get the new week going.

You don’t want to make a ton of risky bets and lose a bunch of money, so, I would consider betting on these teams for some return on investment.

Ready to roll with one of these bets? Head over to the best NFL betting sites now.

Anthony Haage
Anthony Haage

Anthony is a sports writer for covering the NFL, NBA, MLB, NHL, and more. He also covers other various topics such as entertainment, general sports betting tips, and more.

His favorite teams are the Chicago Bears, Bulls, Cubs, and Blackhawks. He also will be a temporary fan of any team if it means winning him bets.

More Posts by Anthony Contact Anthony Anthony on Twitter



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