Los Angeles Rams vs. San Francisco 49ers – NFL, Monday, November 15, 2021

Matthew Stafford took some serious hits in Week 10. The Titans devoured the offensive line of the Rams and it was the most challenging defeat they took on the season.

Cooper Kupp and Robert Woods still posted solid numbers in their Week 10 loss, but they were playing from behind the entire game. The defense struggled against Ryan Tannehill in pass coverage and failed to play good enough defense to give the offense a chance to come from behind.

The team is still an elite squad on paper, but they will need to put their prior loss behind them and focus on the NFC West. Going up against San Francisco will be a slugfest. The 49ers bring plenty of big bodies that can wreak havoc at the line of scrimmage.

The San Fran offense had their struggles in a recent loss to Arizona. Both teams are looking up at the standings to the Cardinals. A lack of explosive plays has cost them dearly.

This Monday Night Football clash between the Rams and the 49ers should be a defensive battle. Here are your latest odds, courtesy of SportsBetting.ag.

This MNF battle in the NFC West may not feature a ton of points on paper. The 49ers have covered in seven of their past ten meetings with the Rams. San Francisco is 7-3 straight up in those meetings.

We have seen the 49ers find some success in the role of a home underdog. They are 6-4 against the spread and 5-5 straight up in their past ten. The Rams have won five straight as a road favorite, but they are average with a 5-5 record against the spread.

If you would like to make wagers on stars such as Cooper and Matthew Stafford, check out our complete guide to understanding prop bets. It is time to dissect the latest keys to victory for MNF between the Rams and 49ers.

The reason for Super Bowl optimism on the Rams is their passing attack led by Matthew Stafford. Any signal-caller that cannot get rid of the ball in time needs to make adjustments. We saw in Week 9 against the Titans that the pressure was too much. So, Stafford will get back to the drawing board and make winning plays.

He has never won a postseason game (0-3), but he has a few weapons in his entire playing career. Calvin Johnson was a Hall of Famer, but the coaches and defenses in the history of Detroit were atrocious more times than not.

Sean McVay is a tremendous coach that brings plenty of upside to the franchise. They have already appeared in the Super Bowl with Jared Goff under center. Todd Gurley and the defense often carried them in the primetime matchups.

Stafford has enough help to become the top team in the NFC. Cooper Kupp is the reason why the Rams should be considered contenders. He is on pace to shatter several single-season records thanks to a stellar performance thus far.

Kupp has been an unstoppable force, and Stafford continues to find him open to moving the chains. The Rams lack an elite ground game, making those short passes vital.

Jalen Ramsey and Aaron Donald are performing at All-Pro levels again on defense. Ramsey came away with an interception and has often been pivotal towards their success.

Donald still commands double and triple teams in the trenches. He continues to let other players around him make plays behind the line of scrimmage. Putting pressure on Jimmy Garoppolo will likely make them one-dimensional and give the Rams a modest edge as the road team.

The 49ers are at their best when Garoppolo sets his feet and has time in the pocket. When he scans the field and finds tight end George Kittle, the team is better off.

Their playoff hopes were looking dead in the water a few ago after their disappointing and disastrous performance against the Colts. While plenty of wins could be ahead to start thinking about the playoffs, they are better off with their top players in the lineup. Kittle in his first game proved to be pivotal.

The defensive ability that San Francisco has at their display is much better than they have shown on the gridiron. Allowing Colt McCoy to play like his old days in the Big 12 with Texas was not ideal for Kyle Shanahan.

This squad is known for its ability to control the line of scrimmage and pin their backs and harass quarterbacks. Fred Warner, Jimmie Ward, Arik Armstead, and Nick Bosa are the stars capable of getting after Stafford.

A few pressures and sacks would give the San Francisco offense the ability to win field position. Short fields often result in points, and the 49ers would become an underdog destined for the upset at home.

If you are unsure how or where to place a wager, please check out the top NFL betting sites.

Robert Woods and Van Jefferson have been able to contribute for the Rams. They are the x-factors in this game due to San Francisco likely concentrating on Kupp.

Jefferson is a capable performer in the red zone. When he gets featured, he often comes down with any jump balls that Stafford throws in his direction. The 49er defense has lacked the killer instinct this season. I foresee the Rams getting over the hump on Monday Night Football.

The Rams offense is more consistent with Stafford threading the needle. While the 49ers are always a tough out at home, Los Angeles is more likely to bounce back after their Week 9 loss. Take the Rams with the points on the road.