NFL Upset Picks to Bet On in Week 3 of the 2021 NFL Season

| September 21, 2021 11:35 am PDT

Week 3 in the NFL is coming up hot and we have some underdog bets to make. We have witnessed some pretty exciting upsets this year, most recently being the Ravens beating the Chiefs on Sunday Night Football.

Week 3 should have some upsets as well, so let’s try and make some big money on them. Here are my favorite NFL upset picks of the week that you can target wherever you bet on sports online.

Green Bay Packers (+170)

In my safest NFL picks for week three, I took the Packers +3.5 against the 49ers. I think it is very weird how the Packers come into this game as the underdog, when they came into the season being a Super Bowl contender.

Their Week 1 matchup was likely a wakeup call for Aaron Rodgers and the offense and could have lit their fire.

Green Bay’s domination on Monday Night Football against the Detroit Lions was evidence of that. Just look at what Aaron Jones did in that game.

  • 67 rushing yards
  • 6 catches
  • 48 receiving yards
  • 4 total TDs

Rodgers also has had a chip on his shoulder against the 49ers ever since they passed on him to draft Alex Smith in 2005. I think the wakeup call against the Saints and the extra chip on Rodgers’ shoulder is going to fuel the Packers to a Week 3 victory against the 49ers.

The 49ers struggled to beat the Lions (towards the end of the game) and the Eagles. They had a huge lead after halftime against the Lions, but they nearly came back at the end and only lost by 8.

The Eagles and the 49ers had a defensive showdown, and the 49ers ended up winning 17-11. I have not been impressed with the 49ers yet this season despite their 2-0 record and they don’t know if Jimmy Garoppolo is their key to winning.

I’m taking the Packers here in an “upset.”

Minnesota Vikings (+105)

The Vikings offense has been impressive behind Kirk Cousins. Ignoring their record of 0-2, you can see how their offense has put up a solid 28.5 points per game.

They have one of the best running backs in the league in Dalvin Cook and they also have a great receiving core. They should be able to put up enough points on the Seahawks, which means the game is going to come down to their ability to stop the Seahawks offense.

Their defense has given up the 5th most points out of any throughout the first two weeks in the NFL. The Bengals were able to beat them in overtime while scoring 27 points, while the Cardinals scored 34 on them.

The Cardinals game could have looked different in the standings, as kicker Greg Joseph missed the go-ahead field goal in the dying seconds of the game.

This game is going to be high scoring, as the Seahawks offense has the ability to put up big points, as well. The Vikings need to limit the big plays for the Seahawks, specifically Tyler Lockett, who has been on a tear to start the season.

They can also run the ball well, which means they can keep the Seahawks offense off the field and run the clock. If they can do both of those things, they can get their first win of the year in front of their home crowd.

Atlanta Falcons (+145)

Now, you might lean towards the Giants here after their near win over the Washington Football Team, but the Falcons are capable of an upset here.

The Falcons made things interesting with the reigning Super Bowl champs, but ended up falling short. The game was closer than the score (25-48) indicates, as Matt Ryan threw two fourth quarter picks (one for a touchdown) to the same player (Mike Edwards).

The score was 25-28 after 3 quarters of play, so it was a good game by the Falcons up until then.

Now, the Giants are not the Buccaneers and they probably won’t blow out the Falcons like they did in Week 3. Daniel Jones did look good against the Washington Football Team and he could have had an even bigger game if Darius Slayton didn’t drop a touchdown.

Jones is coming off a good game, but he has been widely inconsistent in his career. Maybe he will come into this game a little unprepared and with too much confidence since he had a big game last week.

This could be a nice first win of the year for the Falcons on the road, as they look towards their future behind potential star tight end Kyle Pitts.

Los Angeles Chargers (+240)

How crazy would it be for the Chiefs to lose two straight games after making it to two straight Super Bowls? This might actually happen this week with the Chargers on their schedule.

The Ravens narrowly upset the Chiefs on Sunday Night Football and it was one of the most exciting games of the year.

The Chargers are currently in last place in their division (1-1) with the Broncos and Raiders leading the way at a perfect 2-0 after the first two weeks of the year.

Who would have thought the standings would look this way at any point in the season this year?

The Chiefs are not an indestructible team, but they are very hard to beat. Patrick Mahomes and their lethal offense is nearly impossible to stop, while they also have a very talented defense.

The Ravens were able to use their very strong run game to put up 36 points on them in their victory, but it was not an easy task. The Chargers don’t have nearly the strength of a rushing attack that the Ravens do, so they are going to have to do this from the arm of Justin Herbert.

Herbert is going to have to have another big game, which he has had against the Washington Football Team and the Dallas Cowboys with 337.5 passing yards per game.

Despite Herbert needing to have a big game, I think the Chargers defense is the key to their potential win here.

They have been on lockdown to begin the year and they should be able to put up a strong fight against the Chiefs.

Last season, the Chargers went 1-1 against the Chiefs, but their win in Week 7 was against the Chiefs backups as the starters rested for the playoffs. Their Week 2 matchup was really close and ended on an overtime field goal, which led to a Chiefs victory.

The final score ended up being 20-23, proving the Chargers capable of putting up a fight against the Cheifs. They were without one of their star defensive players in that game as well, but Derwin James will be playing in their Week 3 matchup in 2021.

This is going to be a very difficult game for the Chargers to win, but they have the talent to do it and the oddsmakers have them as a pretty big underdog, which means potential for a big payday.

My Top NFL Upset Pick for Week 3

I have to go with Aaron Rodgers and the Packers in Week 3. It’s rare that the safest pick of the week and the top upset go together, but here we are.

I find it very odd that the Packers are an underdog coming into this game, which means they just might be the steal of the week.

The oddsmakers are either making a huge mistake, or they know something that no one else does. Either way, I’m riding with the Packers and Aaron Rodgers in this one.

For help betting on pro football in week three, hit up our free NFL picks section.

Anthony Haage
Anthony Haage

Anthony is a sports writer for covering the NFL, NBA, MLB, NHL, and more. He also covers other various topics such as entertainment, general sports betting tips, and more.

His favorite teams are the Chicago Bears, Bulls, Cubs, and Blackhawks. He also will be a temporary fan of any team if it means winning him bets.

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