Top NFL Picks and Parlay for Week 5 in the 2021 NFL Season

| October 8, 2021 1:16 pm PDT

Every week sports bettors search for the best NFL picks and parlay. The goal? To not just find a few individual bets that can hit – but a string of bets that can win big together.

My top NFL parlay picks haven’t hit yet in 2021, but I came as close as ever in week four. The Lions were a regrettable addition, but every other parlay pick was a success.

I think we’re getting closer. Let’s move full speed ahead to my free NFL parlay picks for week five.

Pittsburgh Steelers to Win (-125)

Everyone has left the Steelers for dead. I totally understand that Ben Roethlisberger very much looks his age these days, but the Steelers have lost to seemingly good teams thus far.

Pittsburgh also beat the Bills in week one, and they are in full-blown desperation mode at 1-3.

The Steelers have an opportunity to get their season back on track here, as they are back at home against a beatable Broncos team.

The matchup isn’t favorable for the Steelers’ offense, but Pittsburgh’s defense could have a field day if Teddy Bridgewater can’t play.

If you think the Steelers are just totally fried, then maybe you’ll hesitate here. However, the best NFL betting sites have them at a -125 price at home in a must-win spot, and it may be too good to pass up.

Tennessee Titans to Win (-200)

I am expecting a big bounce-back game for the Titans, so I am pretty eager to include them in my week five NFL parlay picks.

After an embarrassing overtime loss to the New York Jets, the Titans can get things headed back in the right direction against the winless Jaguars.

This is still a rivalry game that shouldn’t be taken lightly, but the Titans probably learned a hard lesson in last week’s loss.

Tennessee could be getting healthier this week, as star wide receivers A.J. Brown and Julio Jones could be on the mend. That, and the Jaguars are rather distracted these days.

Jacksonville was always going to be impossible to trust, but the Titans are the better team, and they’ll be itching to correct their mistakes in this one.

The -200 moneyline isn’t so bloated that you can’t attack it individually or have it be a centerpiece to your week five NFL parlay.

New England Patriots (-9) -110

Bill Belichick is a master when it comes to bouncing back after a tough loss, while rookie quarterback Mac Jones put on a show in a tight loss in Tom Brady’s homecoming game.

The Patriots are in a prime bounce-back spot against the lowly Texans, and everyone knows how nasty Belichick is against rookie passers by now.

He holds an impressive 22-6 mark against first-year signal-callers, and his defense flat out abused the last rookie passer they ran into.

Davis Mills has been rather abysmal the past two weeks, and I can’t imagine things getting better against a defensive ace like Belichick.

New England is in desperation mode at 1-3, and this is the perfect spot to back them in a likely thumping.

San Francisco 49ers to Win (+205)

I like to make a bold pick I think can return value and also boost my top NFL parlay. A couple of weeks ago, it was the underdog Packers against this very 49ers squad.

This week, I really like the Niners at this price. They are certainly facing some uncertainty with starting quarterback Jimmy Garoppolo injured.

Of course, you can look at this two ways.

First, at the time of this writing, Jimmy G isn’t even ruled out. And secondly, even if he is, the Niners would likely turn to the dynamic Trey Lance, who the Cardinals may not know how to stop just yet.

San Francisco has a tough task in trying to corral Kyler Murray and the Cardinals this week (who happen to be 4-0), but this feels like a must-win spot with the Niners being 2-2.

Given the magnitude of this game and the fact that the 49ers have a more than capable defense, I think there is value in banking on a division rivalry game going the opposite way most people expect.

It’s a risk, but the +205 price for a solid 49ers team is worth a dice roll.

Bills vs. Chiefs Over 56.5 (-110)

I also don’t mind the Bills as one of the better week five NFL upset picks, but betting against the Chiefs at home feels like an unnecessary bet.

Instead, I’ll bank on two very good offenses – and one terrible KC defense – getting this game to 57+ points.

Any other matchup and I may hesitate to bet the Over. However, the Chiefs and Bills both put up 40+ points last week.

Both offenses love to push the pace and let it rip, and Kansas City’s defense alone almost guarantees we get a shootout.

It should be a fun way to close out my week five NFL parlay, especially if my parlay picks are 4-0 up until Sunday Night Football.

My Top Week 5 NFL Parlay

Pittsburgh Steelers to Win-125
Tennessee Titans to Win-200
New England Patriots (-9)-110
San Francisco 49ers to Win+205
Bills vs. Chiefs Over 56.5-110

You will have to (hopefully) sweat this one out through Sunday night, but I like every bet here.

As usual, you can target them individually and/or just pivot off of a pick you’re not super high on.

Some may not be with me on the Niners as a fun upset pick. I get that, so this parlay sans that pick is slated to bring back $415 for every $100 risked at Bovada.

Roll the dice and tack on the 49ers to win, however, and suddenly the payout is $1,472.

My NFL parlays will always assume some risk because that’s how you get the big winnings.

If you want even more advice for the coming week of NFL action, though, check out the safest bets and upset picks below.

Noah Davis

Noah Davis is one of the more diverse writers at Like many of his colleagues, he's a huge fan of both football and basketball. But he also writes about box office records, TV show prop bets, DFS, and all kinds of other subjects.

When it comes to the NFL, Noah's favorite team is the Cleveland Browns. He enjoys cheering them on with his wife and daughter.

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