Best NFL DFS Picks to Roster in Week 16 – Matthew Stafford and More

| December 21, 2021 11:17 am PDT

After perhaps the wildest – and ugliest – week of NFL DFS known to man, it’ll be nice to get back to some normalcy in week 16.

One would hope.

Injuries, COVID-19, and a unique schedule still throw a wrench into our collective daily fantasy football plans, but using the right plays can cure what ails us.

With an eye on taking down some NFL DFS tourneys, here are my top picks going into week 16 at DraftKings.

Matthew Stafford, QB, Rams ($6.7k)

Stafford is too cheap going into week 16. We know what he’s capable of based off of his entire season, as he’s averaging over 23 fantasy points per game in 2021.

Despite a bit of a snag, Stafford has also bounced back as of late, with 23+ fantasy points in each of his last three contests.

This week, he has a palatable matchup with the Vikings. They shut down Justin Fields in their last game, but have otherwise been beatable. Here are their ranks against fantasy passers on the year, and over the last four weeks.

  • Overall in 2021: 30th vs. QBs
  • Last 4 Weeks: 32nd vs. QBs

Minnesota can be tough up front, but their secondary remains rather beatable. That’s bad news going up against a motivated and explosive L.A. passing attack.

Stafford should thrive here, and he’s ultimately too much of a value to pass up when compared to the field.

Austin Ekeler, RB, Chargers ($8.1k)

The fantasy football community had their collective hearts skip a bit when news broke that Austin Ekeler had COVID.

Apparently, those reports weren’t true.

Fingers crossed that Ekeler is fully good to go in week 16. Not only do the Bolts need him, but he would be a smash play against a Texans run defense that has allowed the 7th most fantasy points to running backs in 2021.

It hasn’t been much better recently for Houston, either. They’re just 29th against the position over the last four weeks.

Ekeler is also dealing with an ankle issue, but if he’s active for this game (and not limited like he was last game), he has to be among the best NFL DFS picks to target.

Amon-Ra St. Brown, WR, Lions ($5.6k)

You can say I am late to the party – and maybe I am – but St. Brown continues to look like a great DFS play, and his price hasn’t climbed high enough.

St. Brown smashed last week, but he’s been crushing it for weeks now. Take a look at what he’s done over his last three contests.

St. Brown’s Last 3 Games
Week Targets Catches Yards TDs Fantasy Points
15 11 8 90 1 23.5
14 12 8 73 0 15.3
13 12 10 86 1 24.8

It’s official; St. Brown is the alpha in Detroit’s passing game, and the Lions are trending in the right direction offensively.

Not only that, but he has a mouth-watering matchup ahead of him, as he gets to battle a weak Falcons defense that ranks 29th against fantasy receivers this season.

Mark Andrews, TE, Ravens ($7k)

Mark Andrews is on a heater. He’s racked up an insane 70 fantasy points over his last two outings, hauling in 21 catches and three scores along the way.

The craziest part? He’s done it all without Lamar Jackson.

In week 16, he might get his pal back under center. The two will wage war with the Bengals in a massive battle for the top of the AFC North, while Cincy hasn’t been great (24th) at stopping tight ends.

Add in the possible absence of Travis Kelce due to COVID-19, and Andrews may be the top play at a typically top-heavy DFS position.

Los Angeles Chargers Defense ($3.4k)

If you can swing it, pairing the Chargers with Ekeler looks like a fine stack for week 16. Ekeler should run all over Houston, and the Chargers should be able to contain a usually toothless Texans offense.

Houston did have their way with the sad sack Jaguars last week, but L.A. has playoff aspirations, and is a vastly more talented defensive unit.

The Texans scored a grand total of 27 points over their three previous games before exploding last week.

In a far worse spot this week, the Texans should struggle, and Los Angeles should benefit greatly.

More NFL DFS Picks for Week 16

  • Jalen Hurts, QB, Eagles ($6.4k)
  • Javonte Williams, RB, Broncos ($6.1k)
  • Cooper Kupp, WR, Rams ($9.1k)
  • Kyle Pitts, TE, Falcons ($5.8k)
  • Seattle Seahawks Defense ($3k)

Here’s another batch of solid week 16 NFL DFS picks to consider. Hurts is cheaper than Stafford and offers a better floor due to his rushing ability. I just trust Stafford a little more.

If you’re playing Stafford, you’re likely stacking him with someone. Kupp is the main guy to use; I just didn’t want to get too lazy and have him as one of my core plays for this week.

Williams has a huge role for Denver and will keep getting the rock against the Raiders. Las Vegas has given up the third most fantasy points to running backs this year, so there’s that.

I hate tight ends, now and forever. Pitts is reasonably priced and gets the Lions, though. I also don’t love Seattle, but the Bears are a total mess, so once again, you could do worse.

Hopefully my week 16 daily fantasy football picks serve you well. Want advice for your season long fantasy football leagues? Check out our comprehensive week 16 fantasy goofball guide below.

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Noah Davis

Noah Davis is one of the more diverse writers at Like many of his colleagues, he's a huge fan of both football and basketball. But he also writes about box office records, TV show prop bets, DFS, and all kinds of other subjects.

When it comes to the NFL, Noah's favorite team is the Cleveland Browns. He enjoys cheering them on with his wife and daughter.

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