Louisville Cardinals vs. Ole Miss Rebels – College Football (September 6, 2021)

By Dan Vasta in College Football
| September 5, 2021 5:51 am PDT

The Rebels and Cardinals will bring the offensive fireworks, and points will be flowing on Labor Day night.

Matt Corral is the perfect dark horse to win the Heisman due to his athleticism. He has exceptional speed and can matriculate the ball down the field in Lane Kiffin’s high-octane offense.

The schedule is a doozy for Ole Miss, and this will be a mandatory game for them to win. Louisville may not have the weapons to go score for score with the Rebels, but they have enough to keep it competitive.

Malik Cunningham is another quarterback that can post gaudy numbers in an offense that needs to carry their struggling defense.

Ready to get into the action? Be sure to use the top college football betting sites, and then dive into my Louisville vs. Ole Miss prediction and pick to help you do just that on Labor Day.

Louisville vs. Ole Miss Odds

Louisville (+10.5)-115
Ole Miss (-10.5)-105
Louisville to Win-300
Ole Miss to Win+250
Over 75.5-110
Under 75.5-110

Lane Kiffin had success last season in the SEC West, but their Outback Bowl upset over Indiana has given them high hopes of putting together a Top 25 type of season.

By the numbers, Kiffin went 4-6 against the spread last season with two outright victories as the underdog.

Louisville is coming off a disappointing 4-7 year, but Scott Satterfield is the perfect coach as an underdog. The former Appalachian State coach is 44-39-4 against the spread in his coaching career, with some outright victories in the underdog role.

After posting an 8-5 year in 2019, Louisville is looking to get back towards a postseason berth despite a challenging schedule. UCF, Florida State, Boston College, NC State, Clemson, and Kentucky are all games that could go against the Cards.

For Louisville to get back to the postseason, they need to build some confidence and keep it competitive against the power clubs. Satterfield is 4-2 in non-conference games, which is respectable.

Let’s dissect this game further by breaking down the keys to victory for Louisville and Ole Miss in this non-conference shootout.

Why Louisville Wins

Malik Cunningham is a capable passer that can move the chains with his legs. Cunningham ran for over 600 yards with seven scores on the ground last season.

Seriously, the guy is a freak.

Javian Hawkins is in the NFL at running back, and the top targets in the passing game are gone, too.

Tutu Atwell and Dez Fitzpatrick are both gone, as well, but Cunningham has the skills to take over games and bust off chunk plays on critical third downs that often take the sails out of the defense.

An experienced offensive line should allow them to sustain drives and tire the defense out. If Louisville can keep the points flowing and have long drives, the Ole Miss offense will get antsy on the sidelines.

It will give them a puncher’s chance to pull the upset off.

Why Ole Miss Wins

Lane Kiffin is an offensive guru, and the numbers could be staggering this season. Matt Corral is the top quarterback in the country when he can take care of the ball. In two losses against LSU and Arkansas, he was turning it over like it was his job. The games against Alabama, Kentucky, and Indiana (Outback Bowl) were overly impressive.

Corral has the speed, athleticism, and confidence to deliver the goods. That’s why he’s widely regarded as one of the most explosive players in college football.

Jerrion Ealy at running back leads a deep group that can take any carry to the house. Ealy didn’t play in their bowl, and the offense was still explosive.

Snoop Conner and Henry Parrish combined for over 100 yards. They are a devastating duo when the opposition is expecting the play to be a pass. Their development will be vital to the success of the offense.

Ultimately, the offensive ability for the Rebels will be challenging for any opposing defense.

The fast-paced high-tempo offense could be the best in America if their receivers can replace Elijah Moore.

Louisville vs. Ole Miss Prediction

The Rebels offense will be too much to contain for Louisville’s defense.

The Cardinals offense can keep it close, but the Ole Miss offense will be among the leaders in the country. Corral will give the Louisville defense nightmares.

Dontario Drummond, Jonathan Mingo, John Rhys-Plumlee, and Braylon Sanders could all haul in scores in this matchup. Corral will start to move up the Heisman rankings after he ends up with 300-plus yards and a handful of scoring drives in this shootout.

The Rebels could hang a 50-burger in their season-opening victory.

Louisville vs. Ole Miss Pick

There is an opportunity to take Louisville with the points, but I don’t have any faith in their rushing attack.

The defense will have issues defending all of the weapons on the perimeter, and the Rebels will have a field day. The Louisville talent has been struggling on defense, and woes could roll into ACC play.

The over on the point total is worth consideration, but this game should be more about the Rebels and their ability to dominate. Corral is going to have scouts drooling with some of the plays he makes. He has the arm strength to thread the needle and fit the pigskin into tight windows.

Ole Miss should win this by a few scores, and their offense will keep them in nearly every game this season.

  • Ole Miss (-10.5)



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