Louisiana vs. Iowa State Betting Preview – College Football, September 12, 2020

| September 4, 2020 11:21 am PDT

While a few teams in the Big 12 scheduled a cupcake opponent for their “plus 1” game in 2020, Iowa State will have their hands full.

The Ragin’ Cajuns roll into Ames on September 12th to battle the Cyclones in what will be the season opener for each program. Billy Napier’s bunch won 11 games in 2019 and has playmakers all over the field. Brock Purdy has a few weapons of his own and has aspirations of winning the Heisman.

Let’s dive into the matchup and start keying in on a Louisiana vs. Iowa State prediction.

Louisiana vs. Iowa State Odds

Louisiana (+11)-110
Iowa State (-11)-110
Louisiana to Win+310
Iowa State to Win-420
Over 57-110
Under 57-110

Iowa State is ranked in the top 25, they’re playing at home, and they’re the ones who play in a Power 5 conference. We knew the best football betting sites were going to install the Cyclones as a considerable favorite, but 11 points is quite substantial.

Keep in mind, Matt Campbell’s group posted a 5-7 mark against the spread in 2019. They were 2-4 ATS in home games in which they were favored.

On the other hand, UL-Lafayette covered 64.3% of the time (9-5).

Worth noting, if a bettor backed the “under” in every game that these two schools played in a season ago, he/she walked away with a solid ROI. 

Louisiana vs. Iowa State Matchup

After initially deciding to allow 25,000 fans to attend the game at Jack Trice Stadium, Iowa State has backtracked. AD Jamie Pollard was essentially backed into a corner after the community ridiculed the university for their “out-of-touch” decision.

Given that more than a quarter of the students on the campus in Ames have already tested positive, reversing course seems like a very wise decision.

Now that part of the “home-field” edge has been wiped away for the Cyclones, look for the Cajuns to take advantage.

Brock Purdy is the game’s quarterback who is receiving all the hype, but don’t sleep on Levi Lewis and his prowess in the pocket. The undersized lefty picks his spots carefully and plays with a ton of heart, and he’s got a couple of beasts in the backfield to rely on in early downs.

Case in point – Louisiana-Lafayette pounded the rock in 2019 to the tune of averaging more than 257 rushing yards per game (6th in FBS). Elijah Mitchell and Trey Ragas both return and will be “all systems go” for this matchup versus the Cyclones.

Unfortunately for Purdy and the Iowa State attack, receivers Deshaunte Jones and La’Michael Pettway have both moved on. Four of five starters on the offensive line are no longer with the team and there’s not a ton of depth at running back behind Breece Hall.

Did I mention that Brock Purdy is going to have to carry this unit on his shoulders, or did you start to catch my drift?

Louisiana vs. Iowa State Pick

Matt Campbell better have his troops ready from the get-go or the 2020 season is going to get away from the Cyclones quickly. A home game against UL-Lafayette should prep them for a  series of arduous Big 12 tests that loom on their schedule, but this one is far from a gimmie.

Look for the Ragin’ Cajuns to give the Cyclones a run for their money and hang around until the very end. In fact, I wouldn’t be shocked to see them win the game outright.

A heavy-run attack featuring lots of variations should keep Iowa State on their heels, and it could be a while until Purdy and his new core of wideouts start firing on all cylinders.

Being that I’m torn on who walks away with a W, the 11-point spread tells you all you need to know.

  • Louisiana (+11)

More College Football Picks

Once you lock in your Louisiana vs. Iowa State prediction, don’t be shy about hitting a few more games on the September 12th slate.

Here are three of my other best college football bets of the weekend.

Michael Wynn

As a former Division I collegiate golfer, Michael Wynn loves writing about golf. He's also an expert in most of America's most popular sports, writing extensively for GamblingSites.com on football, basketball, and baseball.

Michael's a Las Vegas native and has been with the company since 2017.

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