Friday’s MLB Predictions and Betting Tips (May 7, 2021)

| May 7, 2021 5:00 am PDT

Friday’s 15-game slate features the start of new series all over the lot. Philly is fresh off a four-game sweep of Milwaukee and is on their way to Atlanta. The Yankees welcome the Nationals in one of three interleague games on tap, while a trio of pitchers aims to get to 5-0.

If Jack Flaherty can take care of business at home against the Rockies, the Redbirds ace will become the first six-game winner in the majors.

For MLB predictions for May 7th and a dive into the best baseball bets of the day, continue reading below.

MLB Game Winner Predictions for May 7th  

  • Pirates to beat the Cubs
  • Red Sox to beat the Orioles
  • Yankees to beat the Nationals
  • Diamondbacks to beat the Mets
  • Indians to beat the Reds
  • Marlins to beat the Brewers
  • Tigers to beat the Twins
  • Braves to beat the Phillies
  • Rangers to beat the Mariners
  • White Sox to beat the Royals
  • Astros to beat the Blue Jays
  • Cardinals to beat the Rockies
  • Dodgers to beat the Angels
  • Athletics to beat the Rays
  • Padres to beat the Giants

*Stats referenced are through Wednesday

If attacking the money line and/or parlays are in your wheelhouse, these MLB picks today are a good place to start. My gut tells me Zach Pleasac will show up in a crossover matchup with the Reds, but the way Wade Miley has been hurling has me treading rather lightly. 

Another AL vs. NL matchup garnering plenty of interest is the battle of La La Land. The Dodgers head to Angel Stadium to take on the Halos after a much-needed reset on Thursday. Dave Roberts and his crew have dropped 13 of their last 17 games and currently sit in third place in their division.

Top MLB Upset Picks for May 7th

  • Pirates +126 (over the Cubs)
  • Diamondbacks +121 (over the Mets)

The Cubs enjoyed a day off on Thursday after Anthony Rizzo’s walk-off single on Wednesday resulted in a sweep of the Dodgers. The Pirates have cooled significantly after a solid start having lost six of their last seven contests.

At first glance, this looks like a game that the Cubbies should have no problem winning. The Pirates rank 27th in runs per game, and Trevor Cahill (Friday’s starter) has been really up and down. Having said that, Zach Davies hasn’t thrown a pitch in the fifth inning or beyond in any of his last five starts. He’ll be making his third appearance against Pittsburgh, and here’s what happened the last time he faced the Buccos lineup.

Zach Davies – A Start to Forget Against the Pirates
Date Innings Hits Earned Runs Strikeouts Walks Pitch Count
4/10/21 1.2 5 7 2 3 44

+126 is a nice number to latch onto in this spot.

Transitioning to the game that will be played in Citi Field, it’s easy to be down on Zac Gallen after his most recent outing versus Colorado. However, the D-Backs righty was nothing short of fantastic in his prior start in Atlanta.

I’m banking on Gallen bouncing back against a struggling Mets lineup. New York clocks in dead last in runs per game among all National League teams. Also boding well for Arizona this evening is the fact that they’ve been much more productive against left-handed pitching.

Arizona Diamondbacks Batting Splits in 2021
Batting Average On Base % Slugging % Runs Per At/Bat
vs. RHP .233 .312 .388 0.247
vs. LHP .255 .347 .511 0.119

The Mets are sending southpaw David Peterson (1-3, 4.81 ERA) to the bump.

Best MLB Bets for Friday, May 7th 

  • White Sox over the Royals (-148)
  • Cardinals (-1.5) over the Rockies (+100)
  • Padres over the Giants (-140)

If there was ever a slam-dunk spot at -148, backing the White Sox tonight is it. Finally healthy, Carlos Rodon has emerged and is among the early front-runners in the AL Cy Young chase.

4-0 in four starts with a blistering 0.72 ERA; let’s even remove Rodon’s no-hitter from the equation just for some perspective. In his other three starts, Carlos has given up a total of two runs and is sporting an unheard-of 16.21 SO9 (strikeouts per nine innings).

As for Rodon’s adversary this evening, Brad Keller is searching. The promising 25-year-old is yet to pan out. Keller failed to get out of the second inning in two of his five starts and got torched by the White Sox in April.

If laying -196 on St. Louis is a little rich for your blood, take a shot on the Cardinals at even money on the run line. Jack Flaherty has been wheeling and dealing; the Rockies are a disastrous 2-11 against the run line away from Coors Field.

Speaking of playing poorly outside of Mile High, check out this hideous slash line representing Colorado batters on the road.


It’s safe to say I don’t like their chances at Busch Field against Jack Flaherty.    

Last but not least, among my best MLB picks for Friday, I’ll cut right to the chase about why I’m jumping on the Friars. San Diego’s lineup has already seen Anthony DeSclafani twice this season. After giving up one run across 86 pitches in the first meeting, the Padres tagged DeSclafani for three runs and knocked him out after 76 pitches in the second meeting.

Look for San Diego to jump on the Giants right-hander early in Friday night’s game. That should allow Blake Snell to settle into a groove and collect his second win of the season.

Do any of these MLB predictions catch your attention? Head to the best baseball betting sites and start locking your wagers in.

Michael Wynn
Michael Wynn

As a former Division I collegiate golfer, Michael Wynn loves writing about golf. He's also an expert in most of America's most popular sports, writing extensively for on football, basketball, and baseball.

Michael's a Las Vegas native and has been with the company since 2017.

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