Best Daily Fantasy Football Picks to Target in Week 2 (2021)

| September 15, 2021 12:49 pm PDT

The first week of the 2021 NFL season is over. Thank goodness.

Don’t get me wrong, I love the NFL, and I love fantasy football. But there is nothing more unpredictable than that first week.

It’s arguable we still know nothing, especially after would-be title contenders like the Bills, Titans, Ravens, Browns, and Packers all lost already.

You can see how they’re all shaping up with a look at the latest Super Bowl 56 odds, of course.

In this space, though, all you should care about is getting some of the best NFL DFS picks so you can win some money. For week one, I was mostly spot on.

Calvin Ridley was my lone bad play, while Christian McCaffrey, Jalen Hurts, and Travis Kelce all smashed. Moving into week two, I won’t focus on the top-priced studs quite as much.

With volatility in mind, let’s see which players make the cut in my week two NFL DFS picks.

Justin Herbert, QB, Chargers ($6.7k)

This showdown between the Chargers and Cowboys is expected to be insane. The top NFL betting sites have the game total set at 55, so fireworks could ensue.

If you had doubts about Herbert following his insane rookie season, check them at the door.

He handled himself just fine with 18 fantasy points against a stout Washington defense last week, and this Cowboys defense is far worse.

Dallas allowed 32.2 fantasy points to Tom Brady last week, and Herbert is at home with a nice band of weapons. He also brings rushing ability to the table, and is $1.5k cheaper than the most expensive play at the quarterback position this week.

Herbert is in a smash spot, my friends. He enters week two as my favorite passer in daily fantasy circles.

Derrick Henry, RB, Titans ($8.3k)

C-Mac is overpriced in a tough spot, while Dalvin Cook and Alvin Kamara are better values capable of matching him.

The guy that could crush them all is somehow way cheaper. That’d be Derrick Henry.

How quickly people forget that this dude crushed skulls en route to a 2,000+ yard campaign last year.

Yes, he struggled in week one and failed to score, but the workload (20 touches) was still there even in a blowout setting.

In week two, I am looking for two things; value and guys who could bounce back after letdowns in week one.

Henry checks both boxes. He’s capable of a 40+ fantasy point explosion, and his Titans are facing a must-win scenario against the Seahawks.

Seattle has a solid defense, but Henry is going to be fed early and often in this spot. At $8.3k, I just can’t turn away.

Mike Evans, WR, Buccaneers ($6.1k)

Tampa Bay is stacked. They’re so loaded, that three of their top weapons went off in week one, and there just weren’t enough balls to go around to also allow Mike Evans to have a big day.

Seriously, look at this production.

  • Rob Gronkowski – 29 fantasy points
  • Chris Godwin – 27 fantasy points
  • Antonio Brown – 26 fantasy points

Evans watched his team smoke Dallas through the air, all the while he recorded three catches on six targets.

Most will flee at the site of his 5.4 fantasy points, but you should also recall his immense upside.

Evans has multi-touchdown potential every time out, and in week two he gets a suspect Falcons defense that just got torched by Jalen Hurts. Imagine how they’ll fare against Tom Terrific.

Oh, and Tom Brady has gone out of his way this week to shine the spotlight on Evans.

Three touchdown game, incoming.

Kyle Pitts, TE, Falcons ($5.2k)

I don’t think you need me to tell you that Darren Waller is a good play this week. The guy got 19 targets on Monday Night Football, after all.

That said, he’s $7.6k. Pitts was a bum in his rookie debut, but he saves you $2.4k in salary, and he may offer a lot more upside than anyone cares to admit.

He gets a tough Buccaneers defense this week, but let’s consider the positives.

  • This game has a high total (52)
  • Atlanta will be playing from behind
  • He had 8 targets in week one
  • Bucs can be had by TEs

The Cowboys racked up 65 yards on nine catches in week one, and Tampa Bay did allow nine touchdowns to the position last year.

Obviously the matchup still favors the Bucs, but Pitts is probably going to be better than he was in the Falcon’s opener. With Atlanta set to throw a ton, I love the value and upside here.

Denver Broncos Defense ($3.8k)

I won’t mince words here. Jacksonville was abhorrent in the first three quarters last week, and I don’t trust Urban Meyer one bit.

Trevor Lawrence also tossed three picks in his NFL debut, so no matter how you look at this one, Denver looks to be in an amazing spot.

The Broncos were solid last week, registering eight fantasy points while stifling Saquon Barkley and the Giants. More sacks and some turnovers can be expected for them here, and I can’t see them getting torched by Jacksonville, either.

Ability, matchup, and potential are all there for the Broncos to be the top defense on the board in week two. The only question is if you’re willing to pay that salary.

NFL DFS Advice for Week 2

The first week of the season is always tough to get just right, but things could become a bit clearer in week two.

I think there will be some nice bounce-back games, while other players should be in better spots and could still go overlooked.

Personally, I don’t think Derrick Henry is going to get owned in two straight games to start the year, and I also think Tom Brady will take it upon himself to get Evans more involved.

Pitts is an explosive weapon that should be busy in week two, and a way better matchup should do wonders for Herbert, as well.

I love my top NFL DFS picks for week two, and this looks like a fantastic core to build your lineups around.

Running it back with Cowboys options opposite of Herbert makes sense for a game stack, while I also like the idea of pairing Keenan Allen with the Chargers quarterback.

Be on the lookout for my top NFL DFS sleepers for this week, as well. If you’re ready to make money now and can’t wait for the NFL DFS main slate this Sunday, hit up this Giants vs. Washington betting pick.

Noah Davis
Noah Davis

Noah Davis is one of the more diverse writers at Like many of his colleagues, he's a huge fan of both football and basketball. But he also writes about box office records, TV show prop bets, DFS, and all kinds of other subjects.

When it comes to the NFL, Noah's favorite team is the Cleveland Browns. He enjoys cheering them on with his wife and daughter.

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