Top Daily Fantasy Football Picks for College Football – Week 4, 2021

By Dan Vasta in DFS
| September 24, 2021 5:18 am PDT

Another week is in the books, and there were more exciting performances and games from the past weekend. Florida nearly shocked the college football landscape against Alabama.

The entire state of Florida is searching for answers from this past week, but some capable players can step up by surprise in Week 4. Looking at the early slate of games, most of the matchups are one-sided.

That should allow some backups to get increased touches and provide much-needed value. The stars on the top teams have been shining, so it is time to pick out the perfect ones for your DFS squad.

You can place bets at the top college football betting sites, but if you just want some advice for your daily fantasy contests, I’ve got you covered with my top week four CFB DFS picks.

Malik Cunningham, QB, Louisville ($8,800)

When in doubt, fade one of the worst teams in the FBS. Florida State (0-3) remains winless and clueless defending quarterbacks as September winds down.

Cunningham played well in their dramatic and thrilling upset victory over UCF.

The FSU defense is No. 100 in total defense, allowing 421.7 yards per game.

Those numbers could get even worse as the schedule will soon heat up in Tallahassee. Perhaps, FSU will put some points on the board to make Cunningham keep up the video game-like numbers. The Cardinal signal-caller has run for over 200 yards with six rushing scores.

The rushing ability has enabled Louisville to get to 2-1, which will keep them in bowl contention throughout the season.

The ACC opener could set the tempo for this program, and Cunningham is the perfect leader to take them there.

While the price is far from cheap, this is one of the top plays due to the ability to reach paydirt four or five times against a struggling Seminole defense.

Chez Mellusi, RB, Wisconsin ($6,400)

The preseason chatter was all about Jalen Berger, but days leading up to their eventual loss to Penn State were all about the Clemson transfer.

Mellusi has been toting the rock after two games and is the clear-cut starter over Berger, who did get more work in their previous game against Eastern Michigan.

Here are his stats so far in 2021.

  • 51 rushing attempts
  • 265 rushing yards
  • 2 TDs
  • 5.2 YPC

The Badgers have a storied history of running roughshod on the opposition thanks to their massive offensive line that can open holes for any respectable back. Mellusi doesn’t have blazing speed, but he gets loose in the secondary on a few dazzling plays.

The ability to get in the end zone multiple times is where the value lies. Other players get featured just as much on better teams. The Badgers could be a Top 15 squad if they continue to sustain drives and avoid costly mistakes.

Notre Dame has had issues defending the run through three games and should be worried about this one. The Irish are No. 73 in the FBS against the run (145.7 YPG). ND will get tested against the physicality that Wisconsin brings, which could be leading from the start.

Whether you use Mellusi or not at DraftKings, consider taking a look at my betting preview for this tense week four clash below.

Breece Hall, RB, Iowa State ($7,000)

The Cyclones finally flexed their muscles on offense this past week against dreadful UNLV. Going to Vegas cures boredom, and Iowa State should be ready after taking their frustration out on those Rebels.

Breece Hall was a big part of that. Check out the damage he inflicted last time out.

  • 21 rushing attempts
  • 100 rushing yards
  • 2 TDs
  • 4.8 YPC

Baylor is next on the docket, and the Bears have had one of the easiest schedules in the country thus far. They have gone up against Kansas, Texas Southern, and Texas State. Texas Southern is not even an FBS squad, and the Jayhawks and Bobcats haven’t gone bowling in forever.

The Bear rushing defense is only No. 51 in the nation despite playing against some cupcakes.

The Cyclone rushing attack could have their way in the Big 12 this season, with Hall getting the majority of the snaps. He is a threat to score multiple times towards the goal-line, and the Iowa State passing attack has been inconsistent thus far.

Hall has not had the start to his final season the way he likely envisioned it, but he is fully capable of dominating their conference this season. This team should remain a Top 20 squad, but leaning on their stud back could be a recipe for success in their Big 12 opener.

Kayshon Boutte, WR, LSU ($7,700)

Speaking of traditions at Wisconsin, LSU has had star-wideouts at Baton Rouge for decades. Boutte is the next star that has already shined for the Bayou Bengals.

We often have talked about selecting players in games that could come down to the wire and have several points scored. Both the LSU and Mississippi State defenses have had issues against the better offenses they have seen this season in Memphis and UCLA.

The total could exceed the 56.5 points that the experts in the desert have it labeled.

LSU will be featured in many games this season where you will want to target their team or perhaps the other squad. The Bulldogs are ticked they lost to Memphis on a phantom punt return that was or wasn’t blown dead.

LSU already has a loss on the schedule, and they will need to get after it if they want to avoid a bottom-three finish in the West. Max Johnson has been threading the needle thus far, and there is no argument that Boutte is the top playmaker on this offense.

Boutte is going up against the No. 92 ranked pass defense in the FBS. The Bulldogs had issues defending the Tigers last week but allowing 243.3 yards per game will likely rise after this weekend.

He’s been unstoppable so far this year. Take a look at his 2021 game log.

  • Week 1: 9 catches, 148 yards, 3 TDs
  • Week 2: 5 catches, 32 yards, 2 TDs
  • Week 3: 6 catches, 44 yards, 1 TD 

This LSU wideout has a chance to become one of the best ones in America, and he sure will have an opportunity to play in the NFL like so many former LSU stars have.

Khalil Shakir, WR, Boise State ($7,400)

This Mountain West matchup is another game that could light the scoreboard up. Utah State has a capable offense and should move the ball on the Boise State defense to keep it competitive.

When the Broncos have to get going on the offensive end, they have often called upon Shakir to bail them out.

This wideout is a future Sunday player that can run tremendous routes and explode past defenders. The quickness in and out of his breaks is impressive.

Shakir has hauled in 20 receptions for over 300 yards to go along with two scores through three weeks. The point total is at 70 points for many sportsbooks, which means increased opportunities for the Broncos to throw the ball down the field.

Week 4 College Football DFS Advice

Be sure to study the latest injury reports and trends across the country.

College football DFS is much more fluid than the NFL due to the lack of reporting throughout the week. We will get injury updates and news for Sunday football every other hour during weekday afternoons.

College football has next to nothing until Friday and Saturday, so be sure to double-check your CFB DFS lineups to make sure all of your players are healthy and active. Those point totals continue to come through for finding the top performers.

Week 4 is sure to give us some more surprises in finding the perfect lineup, but these were your top picks for the upcoming weekend. Enjoy the games and best of luck with your squads.

Hopefully my week four college football DFS picks treat you well. For more DFS advice, check out some of the posts below.

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