Top College Football DFS Picks for Week 5

By Dan Vasta in DFS
| September 30, 2021 11:45 am PDT

September has passed us by, and October is finally here. Conference matchups start to arrive every week, and the non-conference is nearly complete for most programs.

We were successful with our selections last week. We had Malik Cunningham, Kayshon Boutte, and Khalil Shakir dominating on the gridiron. Those three were heavily relied upon by their teams. That is vital to pick up the points.

Some other matchups could light up the scoreboard, so get ready to jot down the players to target.

Here are the top college football DFS selections for the opening Saturday in October.

Casey Thompson, QB, Texas ($8,400)

The Longhorns are coming off a sensational performance in their blowout victory over Texas Tech. The Big 12 defenses aren’t exactly lighting the world on fire with their latest efforts.

TEX-TCU could be another game where both offenses need to outscore the opposition due to a lackluster defense. The points were scorching last week, and more of the same will occur against the overrated TCU squad. The Horned Frogs came in with expectations, but they have struggled thus far.

They were nearly upset by Cal at home a few weeks back, but SMU walked into Fort Worth and exposed their secondary. Tanner Mordecai tossed four touchdown passes to go along with 245 yards.

Thompson has more weapons at his disposal than anybody TCU has had on their schedule thus far. The Texas signal-caller is capable of tucking it and running for yardage.

The arm strength is where he can light it up. The matchup has a point total of 65 points, making the Longhorn passer a must-start.

Leddie Brown, RB, West Virginia ($6,900)

There should be a theme that everybody is catching on here with these selections for Week 5. The Big 12 has had issues on the defensive side of the ball for years. This season has been a challenge. Look for more upcoming shootouts.

Texas Tech just finished a pitiful performance in which they failed to slow down the Texas offense. Texas Tech is next up for the West Virginia offense that put a scare into the CFP chances of Oklahoma.

The Sooners should have one of the better defenses in the country this season. The Red Raiders are not in the same sentence as any squad with an elite defense. Take as many Mountaineers and Longhorns as you can this weekend.

Aim to take those that see the field the most for increased opportunities. The key in these DFS leagues is to find your best bet to get the most looks. Brown is the perfect workhorse back that can reach paydirt a few times, and he should have no problem eclipsing 100-plus yards from the line of scrimmage in this Big 12 tilt.

Tyler Badie, RB, Missouri ($8,200)

The Missouri offense has been explosive this season, averaging 38.8 points per game. That is No. 20 in the FBS, and they have been able to churn out plenty of yards as well.

Badie is the perfect piece for your lineup due to the type of game he will be playing this weekend.

Hosting Tennessee has its privileges with a point total of 65-plus points.

The Volunteer defense is No. 53 in points allowed (21.2), but it will go up after this SEC East clash. Tennessee has played Bowling Green and Tennessee Tech to help look more respectable than they are.

Missouri will hang well over 400 yards in a game that likely comes down to the wire. If the game were to go to overtime, we could be looking at video game-like numbers for the starting running back. Missouri has been using Badie out of the backfield as a pass-catcher, which certainly is tempting.

Had this been a matchup against Georgia or Florida, then I would take a pass. The Vols will struggle to control the line of scrimmage in a game that has the makings for turning into a shootout. Take Badie with confidence and expect a 25-plus point performance.

Drake London, WR, USC ($8,500)

USC is an absolute disaster of a football program these days. They have no leadership on the sidelines, and their defense has been a joke. They made Oregon State look like the 1999 St. Louis Rams. The top show on turf doesn’t come to mind with many Pac-12 schools.

The Trojans do have some pieces on offense to make the most of this DFS Week 5 slate. Drake London is another future pro at wide receiver. The Pac-12 has had several stars over the years, and this one should shine against Colorado.

The Colorado secondary has been exposed in spots this season. The tempo of the game will likely turn it into a shootout. London doesn’t need many looks to turn in a stellar performance. He hauls in every target thrown in his direction.

On the season, London already has 39 grabs for 540 yards and three touchdowns. He is averaging nearly 14 yards a catch and will be one of the better plays at wide receiver this weekend.

John Metchie III, WR, Alabama ($7,100)

The game of the weekend to watch and to benefit from is Ole Miss vs Alabama. Matt Corral and Bryce Young are worth mentioning because of what they can do in all facets of the game.

The top pass-catching option should be Metchie in this potential historic shootout. Lane Kiffin will have the points flowing for the Rebels, but don’t doubt Nick Saban’s offense. He has transformed them over the years to become an elite passing squad.

Metchie has been the top target and will likely get peppered with the pigskin. He has hauled in at least five catches for 45 yards in every game. Metchie is overdue to reach the end zone a few times. The upside and potential for a breakout game are there since there will be at least a dozen possessions.

Alabama may need to score 40 points to come out victorious. There will be plenty of quick drives with lots of yards and points occurring.

Don’t pass on this game, be sure to take advantage of the benefits. Metchie is a premier playmaker that can draw separation from opposing Ole Miss defenders. Take this star with confidence.

Week 5 College Football DFS Advice

The slate of games this weekend is off the charts. The SEC alone makes it worthy of spending the day on the couch with winning lineups. Week 5 is the week to have a few of them since there are several different games and teams that you should be eyeing.

The Big 12 and the SEC are two conferences that I would target. Look over those points totals to make sure you aren’t missing out. Study your lineups and keep your eyes and ears out for any injury reports on Saturday morning. Enjoy the weekend, and I wish you all the best of luck with your DFS lineups.

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