Arizona Cardinals vs. Los Angeles Rams – NFL, Week 4

| September 29, 2021 1:18 pm PDT

The Arizona Cardinals head to L.A. to battle the Rams in what is undeniably the biggest NFL game in week four.

Yes, I know, Tom Brady returns to his old stomping grounds to cap Sunday with the most dramatic contest this week, but this NFC East clash between two 3-0 teams is easily one of the best week four NFL games to bet on.

Who will win, and how should you bet? Let’s find out in my week four Cardinals vs. Rams prediction and pick.

Odds for Cardinals vs. Rams in Week 4

Cardinals (+6)-120
Rams (-6)+100
Cardinals to Win+215
Rams to Win-255
Over 54.5-110
Under 54.5-110

You can find the Cardinals vs. Rams odds above at BetOnline, but I encourage you to shop around to find the best pricing available online.

The pricing is pretty good here, though. Arizona comes in as near-touchdown underdogs, even though they have looked quite dynamic en route to a 3-0 start.

But, to be fair, both of these teams are very good, and they’re both undefeated.

Arizona’s defense hasn’t been perfect, but they can defend the pass and get after the quarterback. Their offense can make up for any mistakes the defense commits, too, as they’ve scored at least 31 points in every game thus far.

The Rams aren’t too shabby in that department, either. They’ve put up at least 27 points in every game, displaying an ability to rally or completely dominate opponents.

L.A. is the rightful favorite here, but bettors should be wondering if the spread is a bit too thick. Arizona stands out as the superior value across the board, and the explosive offenses make this 54.5 total stand out as one to target the Over for.

How should you bet, precisely? Let’s inspect this matchup and come away with a prediction and pick.

Cardinals vs. Rams Matchup Breakdown

These are two of the most explosive offenses in football, so a shootout isn’t crazy to expect here.

It’s a weird matchup to break down. The Rams are crushing it through the air and can’t run the ball right now, but Arizona defends the pass well and isn’t stopping anyone on the ground.

Arizona ranks 6th in sack percentage and 8th in opponents yards per pass allowed, but they’ve struggled against the run.

  • 140.7 yards allowed per game (29th)
  • 5.4 yards allowed per play (31st)

Of course, you have to wonder if the Rams can even take advantage of that.

To this point, L.A. has ranked 30th in yards per rush (3.3), and 27th in rushing yards per game (83.7). They’ve dealt with injuries to their offensive backfield, but they’ve also played with a fairly large lead in two of their three wins.

This could be the week their running game gets going, but if it can’t – and Arizona’s strong pass defense shines – it could be a problem for Matthew Stafford and co.

On the other side, the Rams are thriving through the air.

Matthew Stafford is slaying it now that he’s not held back by a bad Lions team, and Cooper Kupp is on a torrid pace because of it.

Obviously, betting against this white-hot Rams passing game feels silly, but it’s at least possible they could struggle with Arizona’s stellar play up front and in the secondary.

The Cardinals, meanwhile, may have the better matchup. They’re the more balanced team between the two, the mobile Kyler Murray is a bit tougher to corral, and the Rams haven’t been as stingy defensively.

Cardinals vs. Rams Prediction

I think the Rams are going to win this game. It’s probably going to be close, back-and-forth, and high-scoring, but they’re at home, and they feel like the more experienced, better-coached unit.

L.A. has serious title aspirations this year, and they may have more game-changers on defense.

Provided they get a healthy Darrell Henderson to potentially exploit the Cards on the ground, they should be able to get the job done.

The Rams are a fine try at their -255 moneyline, but are they going to cover a 6-point spread? That, I’m not so sure about.

Cardinals vs. Rams Pick

  • Arizona Cardinals (+6)

I like two bets for this game; the Over and Arizona at +6.

There is going to be a lot of scoring here. My only question is if the Rams sacrifice big numbers to exploit Arizona’s chief defensive weakness and just try to control this game on the ground.

If they can do that, we’d still get some scoring, and a likely Rams win, but the 54.5 total would be tough to get to. I think it can, but it’s a secondary bet for me in this game.

More than anything, I expect this game to be close.

The Colts played the Rams close in week two, and Arizona barely got by the Vikings a couple of weeks ago. Both teams are vulnerable in certain spots, and both offenses can go off.

While the battle in the trenches likely favors the Rams, this is just a massive divisional tilt between two undefeated teams that are equally tough outs. I think it stays close, making Arizona at +6 a steal for bettors in week four.

To get going in your plight to bet on other week four NFL games, check out the early odds.

Early Week 4 NFL Betting Lines (2021) - Odds and Analysis for Every Game

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Noah Davis
Noah Davis

Noah Davis is one of the more diverse writers at Like many of his colleagues, he's a huge fan of both football and basketball. But he also writes about box office records, TV show prop bets, DFS, and all kinds of other subjects.

When it comes to the NFL, Noah's favorite team is the Cleveland Browns. He enjoys cheering them on with his wife and daughter.

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