Best NFL Parlay for Week 3 in the 2021 Season

| September 23, 2021 10:50 am PDT

My first NFL parlay of the year was regrettable, but week two’s attempt was considerably better. The natural goal in week three is to take one down.

As I say every time, you can target any of my NFL parlay picks individually, or you can mix and match my top NFL parlay with your own favorite picks.

Every NFL parlay takes on risk. You can roll with four -400 favorites and still not get a win. I like to mix some safer bets in with at least one high upside bet, and that leads me to my top NFL parlay for the week.

Let’s go over some of my favorite solo bets for week three at the top NFL betting sites, and land on this week’s top parlay bet.

Arizona Cardinals to Win (-360)

The Cardinals narrowly escaped a loss thanks to a shanked field goal last week, but through two weeks, their defense has flashed upside, and their offense has been on fire.

Kyler Murray looks like a legit NFL MVP threat, and Arizona is putting up 34+ points per game. He has a case for the most exciting player in the game right now, too.

I doubt that stops against the Jaguars, who have looked inept under Urban Meyer to this point.

Chandler Jones and Arizona’s defense should make life hell for rookie quarterback Trevor Lawrence, while there is nothing about Jacksonville’s defense that suggests they can stop this Cardinals offense.

The spread could be tricky with this still being a road game, but I can’t see the Cardinals losing.

I wouldn’t suggest going after this -360 moneyline by itself, but it can add a little money to a fun week three NFL parlay, and feels like one of the safest week three NFL picks.

Tennessee Titans (-5.5) -110

You could also tack on the Titans moneyline here, but I feel good about them covering, and it’s a better price. That feels weird to say, considering Tennessee’s defense has been swiss cheese in allowing 30+ points in consecutive weeks to start 2021.

That said, the Titans have a dynamic offense, and got Derrick Henry rolling last week.

In week three, Henry and co. face a sulking 0-2 Colts squad that simply hasn’t looked good this year. Carson Wentz hasn’t played particularly well, the running game has been non-existent, and the defense hasn’t lived up to expectations, either.

Obviously this could be a spot where that all changes, but the Titans are at home, and it looks like they’ll get Jacob Eason.

Everything sets this up as a Titans win, and after getting crushed in week one and needing OT to win last week, I feel like they’re due to run away with one.

Buccaneers to Win (-130)

The Rams on the road is not an easy task, but I imagine the loaded defending champs will be up for the challenge.

Tampa Bay’s offense has been lights out to start 2021, as Tom Brady tossed five touchdowns last week, and this team still has a capable running game and a stout defense.

Both defenses seem to be overlooked in a matchup with a gaudy 55.5 total at most of the top NFL betting sites, while the Bucs just feel criminally underpriced here.

Los Angeles is better with Matthew Stafford under center, but the Rams barely beat the Colts last week, and if we were to bet on one of these teams starting 3-0 before the season, we’d have hammered Tampa Bay.

I see no reason to go away from that logic now, and the Bucs at -130 just feels like a gift. This is also one of the top NFL games to bet on this week. Let’s just hope we’re going after the right wager here.

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Packers to Win (+155)

This last bet is going to push my week three NFL parlay over the top. The other three bets need to hit, too, obviously, but this one just feels like an elite value bet.

People are still down on the Packers because of their horrific week one blowout loss, but they got back on track with a 35-17 win over the Lions.

The concern over Green Bay’s ugly 0-1 start is beginning to melt away.

San Francisco almost allowed that same Detroit team to rally back in week one, and they didn’t look particularly great last week in a 17-11 win over a suspect Eagles team.

The Niners have issues in their secondary, too, while they’re immensely banged up at running back.

It’s possible San Francisco just runs all over Green Bay at home here, but I see this as a true statement game for the Packers to remind the NFL that they’re a legit title threat.

My Top NFL Parlay for Week 3

Arizona Cardinals to Win-360
Tennessee Titans (-5.5)-110
Buccaneers to Wnn-130
Packers to Win+155

Once again, my favorite week three NFL parlay is not without risk. Every parlay is somewhat risky, as you need every bet to hit to win the cash.

Like usual, feel free to alter my parlay as you wish, switch bets, or omit whatever wagers you’re not high on.

That said, I love the Cardinals, Bucs, and Packers to win this week, and Tennessee should be able to cover.

This exact NFL parlay can turn $100 into just over $1,000 at Bovada and you just need four bets to deliver.

Green Bay and Tampa Bay are simply mispriced in spots I like them in, the Titans are in an advantageous situation at home, and Jacksonville is simply overmatched (when aren’t they?).

You can roll with my week three NFL parlay, isolate the bets, or try a different bet, altogether. For more advice on betting on pro football this week, check out our NFL betting blog.

Noah Davis
Noah Davis

Noah Davis is one of the more diverse writers at Like many of his colleagues, he's a huge fan of both football and basketball. But he also writes about box office records, TV show prop bets, DFS, and all kinds of other subjects.

When it comes to the NFL, Noah's favorite team is the Cleveland Browns. He enjoys cheering them on with his wife and daughter.

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