Best DFS Picks for Week 1 in College Football – September 4, 2021

By Dan Vasta in DFS
| August 24, 2021 9:17 am PDT

College football is back and better than ever. The opening slate of games for Week 1 could be thrilling. There will be a bevy of featured games, but there are plenty of underrated matchups as well.

The star players will have opportunities to flourish in front of the fans. In fantasy football, you need to find the players that will have the most chances to shine.

Getting players that play all four quarters and ones that are involved in shootouts is a double bonus.

It is time to rattle off the top players with the most favorable matchups for the opening slate of games. I will be giving you the best values that will put up great numbers. Most of them are costly, so be wary of the prices.

These college football DFS picks are for the first official weekend of college football games, which is on the first Saturday of September.

Let’s roll up our sleeves and get going with my favorite CFB DFS picks for September 4, 2021.

Will Rogers, QB, Mississippi State ($8,700)

Rogers has a spectacular matchup to start the season against a struggling defense. Skip Holtz’s Bulldogs defense was among the worst in the FBS last season.

Just look at where they finished in some key areas in 2020.

  • 34.7 points per game (96th)
  • 427.3 yards per game (81st)
  • 229 pass yards per game (59th)

Defending the pass against a Mike Leach offense is never a walk in the park. Louisiana Tech had issues against the pass and couldn’t prevent anybody from lighting the scoreboard up last year.

Hail State started their season off on a high note against LSU last season before Rogers even started under center. Having a pass-happy quarterback on your team is a benefit.

Rogers may thread the needle 40-plus times in a game that should feature well over 50 points scored.

Seriously, the best college football betting apps have the total at a cool 52.5.

The Bulldogs have momentum after winning their final two games last season.

Don’t think for a second they will struggle at home in front of a hostile Stark Vegas crowd. Davis Wade Stadium will be rocking, and Rogers will reap the benefits on your fantasy team.

Dollar for dollar, he feels like the best quarterback play at DraftKings in week one.

Deuce Vaughn, RB, Kansas State ($6,300)

The Deuce is going to run loose on a struggling Cardinal defense. Kansas State has one of the toughest college football schedules in 2021, but that won’t impact Vaughn in week one.

This game is one of the more underrated matchups that could come down to the wire. Vaughn is among the more expensive backs, but there is value on the 2020 National Freshman of the Year.

Vaughn will go up against a Stanford defense that was No. 112 against the run last season, allowing 222.0 yards per game.

Those defensive numbers are staggering for a David Shaw-led team, but Stanford has fallen from grace.

There is an incentive for both teams to put forth their best efforts. A loss by either team could prevent them from earning a bowl berth this season. Stanford has a brutal schedule, but the Wildcats should have an edge in this one.

Kansas State has an explosive home-run hitter that you need to take a few times this season. There will be a few players posting gaudy numbers on the opening weekend. Vaughn is the best choice due to his breakaway speed and dual-threat ability.

If the Wildcats decide to pass the ball, Vaughn will benefit there as well. He led the team in receiving yards last season (434). Fire Vaughn up in your college football DFS lineups in week one, as he will be running wild on the fast track at AT&T Stadium.

Marvin Mims, WR, Oklahoma ($7,700)

The Oklahoma Sooners offense this season will be the best in the nation. You might even be a bit shocked to see where I have them winding up in my 2021 college football New Year’s six bowl game predictions.

They will be among the nation’s leaders in points with one of the finest pass-catchers. Spencer Rattler might win the Heisman, but his primary target will be Mims.

Lincoln Riley has instilled a winning formula by ranking among the top offenses in the nation year after year.

Just look at how nasty they’ve been since 2018.

  • 2018: 48.4 points per game (1st)
  • 2019: 42.1 points per game (6th)
  • 2020: 43 points per game (6th)

Riley always has a tremendous offensive line with a uber-talented quarterback under center. The biggest winners have been top wideouts over the years but look at the consistency this offense has brought.

The Sooners have a tradition of dominant passing options, and Mims is a great option. Oklahoma could rest their starters in the fourth quarter, but there will be staggering numbers in the first two-plus quarters.

Tulane doesn’t have a prayer of staying within two touchdowns of Oklahoma due to their high-octane offense. Rattler has a bevy of weapons, but Mims is the top one due to his big-play ability.

He showed down the stretch of the season that he has the goods to become an All-American target for Rattler. For week one, he feels like one of the best CFB DFS picks money can buy at DraftKings.

Jalen Berger, Flex/RB, Wisconsin ($6,100)

Badger football is big boy football when it comes to the trenches. Wisconsin returns nine starters on offense from a season ago, but Berger brings the most upside among all players.

Graham Mertz is a capable quarterback for Wisconsin, but the season opener against Penn State will be one of the top matchups at the line of scrimmage.

Berger picked up momentum in their Mayo Bowl victory over Wake Forest, but this team should become a Top 10 team this year.

    The Badgers will lean heavily on the ground against Penn State.

The Badger back will become more expensive as the season progresses, but take advantage before you are last to jump on the bandwagon. Berger will feast on the Big Ten slate this year, and owners should reap the benefits in the season opener.

In addition to week one, Berger will be awfully appealing for some time after, assuming his price doesn’t skyrocket. He’s a big reason why the Badgers should be among the NCAA football teams most likely to improve this year.

NCAA Football Teams Most Likely to Improve in 2021

Some college football teams come off struggling seasons in which they fail to live up to their expectations every year. Others get fortunate breaks or start the season near the Top 10 and fail to finish the season ranked. Many redshirt sophomores or juniors...

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Hassan Haskins, Superflex/RB, Michigan ($6,200)

Many will try to find quarterbacks, but that will require you to take a few shots in the dark at running back and or wide receiver. An advantage Michigan will have in this game will be running the ball downhill with Haskins.

The Michigan starting tailback went off in the final two games last year. Check out his solid stat lines.

  • @ Rutgers – 23 carries, 111 rushing yards, 1 TD
  • VS. Penn State – 17 carries, 101 rushing yards, 2 TDs

He will be looking to ride that momentum into his best season yet in Ann Arbor.

Harbaugh has had issues at quarterback for as long as he has been with Michigan. Running the ball with authority is what he prefers to dial-up as the head coach, and Michigan is at its best when they can control the time of possession.

The goal-line will be a friend of Haskins this season due to his stature and running style. The north-south grinder will need to have a decent workload in the opener to prepare for a showdown with Washington the following week.

Light up Haskins against Western Michigan in your week one CFB DFS lineups, and you will enjoy the 20-plus point performance.

Week 1 College Football DFS Advice

There are a few strategies you need to keep in mind before setting your week one college football DFS roster.

Put together a list of players and games that you like most. If there are premier games that may not feature a bevy of points (Indiana-Iowa), stay away more times than not.

Here are five notes to jot down when rostering a winning team.

  • Study the Over/Unders
  • Known Tendencies of Teams
  • Salaries & Percentage Owned
  • Premier Players on Relevant Offenses
  • Avoid RBBC (running back by committee)

I am fine fading some premier players if it lets you stack a team involved in a shootout. Every week will have different trends, but try to follow where teams lean once the season is underway.

Also, don’t ignore the ownership that a player has. That will help make your decisions when kickoff arrives.

These are my top college football DFS picks for week one. Hopefully they treat you well. There is money to be made in betting on college football, too, though.

For advice on games, stop by our college football betting picks page.



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