San Francisco 49ers vs. Dallas Cowboys Pick and Prediction for Wild Card Weekend (2022)

By Nick Sterling in NFL
| January 14, 2022 11:43 am PST

It’ll be a bit of a throwback game as the San Francisco 49ers travel to Dallas to take on the Cowboys. The teams had numerous playoff battles in the 1980s and 1990s. That also represents the last time either team won a Super Bowl.

Among the six games on wild card weekend, this is the only one where the teams will play for the first time this season. Could that lead to a surprise result? Let’s start things out by checking out the odds.

49ers vs. Cowboys Odds

San Francisco 49ers (+3.0)-105
Dallas Cowboys (-3.0)-115
San Francisco 49ers to Win+142
Dallas Cowboys to Win-162
Over 51-107
Under 51-113 has the Dallas Cowboys as a (-3.0) point favorite. That’s great news for Dallas because their 13-4 record against the spread was the best in the NFL this season. Now what’s interesting is they lost outright three times as the favorite.

Dallas finished 8-9 with their over/under, but they went under in four of their last six games.

The San Francisco 49ers were in the middle of the pack with their record against the spread. They failed to cover in five of their first six games but closed the season covering in four of their last five games.

Like the Cowboys, they also went 8-9 with the over/under.

The biggest question mark for the 49ers is Trent Williams. The All-Pro left tackle missed their Week 18 game with an elbow injury, but it sounds like he’ll be ready to go on Sunday.

Dallas was dealing with a few COVID cases, but it sounds like their only true question mark for this game is Keanu Neal.

Before my game pick, let’s preview the 49ers and Cowboys.

San Francisco 49ers Preview

The San Francisco 49ers came into the season with a lot of hype. They were among the Super Bowl contenders as people were expecting them to replicate their 2019 season. That didn’t come to fruition in the first half.

San Francisco recovered from a 2-4 start, winning eight of their last 11 games to make the playoffs as a wild card. Truthfully, I think they are a wild card team capable of making a Super Bowl run.

Everyone knows about the 49ers’ ground game and defense, but their passing game impressed me down the stretch. Jimmy Garoppolo only cleared 260 yards three times in his first 10 games. Check out his passing yards in his last five games.

  • Week 13: 299
  • Week 14: 296
  • Week 15: 235
  • Week 16: 322
  • Week 18: 316

I think Garoppolo will be the X-factor in Sunday’s matchup. He should lean on Deebo Samuel and George Kittle. Speaking of Samuel, how amazing has he been this season?

Samuel was a significant factor in the first half, clearing 100 receiving yards in four games. In the second half, San Francisco took advantage of his dual-threat ability. Check out his rushing stats on the season.

  • 59 carries
  • 365 rushing yards
  • 8 touchdowns

His rushing yards are the ninth-most in a single season for a wide receiver. However, we should account that nearly all his yards came in his final eight games. If you use that metric, he would have 42.9 rushing yards per game. That would rank second all-time.

Samuel will play a big role for the 49ers’ offense as they look to upset the Dallas Cowboys. I’m looking at the 49ers’ offense as a whole because they’ll need to score to keep up Dallas’ No. 1 offense.

Dallas Cowboys Preview

All season, the Dallas Cowboys have been among the top contenders in the NFC. They had a down stretch in the middle of the season, losing three of four games. However, they recovered to win five of their last six games to clinch the NFC East.

Dallas dominated opponents with their No. 1 offense. Dak Prescott was the driving force, but he had plenty of help from CeeDee Lamb, Amari Cooper, and Dalton Schultz. Check out their numbers this season.

  CeeDee Lamb Amari Cooper Dalton Schultz
Receptions 79 68 78
Yards 1,102 865 808
Touchdowns 6 8 8

Michael Gallup had just made his way back into the lineup. Unfortunately, he tore his ACL in Week 17.

It’ll be interesting to see how the Cowboys perform against the San Francisco 49ers defense. San Francisco allowed the sixth-fewest passing yards this season. They also had one of the best run defenses, so something will have to give.

As much as everyone loves to talk about Dallas’ offense, I want to give their defense some props. They allowed a decent amount of yards but allowed the seventh-fewest points.

They also had a nose for the ball. The Cowboys defense led the league with 26 interceptions and 34 turnovers. Their defensive leader was none other than Trevon Diggs. Let’s check out his numbers.

  • 11 interceptions
  • 21 passes defended
  • 2 touchdowns

Diggs became the first player since Everson Walls in 1981 to record more than 10 interceptions. He needs to keep up his stellar play if the Cowboys are going to make a Super Bowl run.

The Cowboys have to take care of business against the 49ers before thinking about the Super Bowl. Which side am I going with for this matchup? Here is my game pick.

49ers vs. Cowboys Pick

  • San Francisco 49ers (+3.0)

I know the Dallas Cowboys come in as the favorite, but I like the San Francisco 49ers to win outright. These teams were moving in a bit of a different direction at the end of the season.

If you take out the Week 18 game where they faced the Philadelphia Eagles backups, Dallas hasn’t defeated a team over .500 since Week 13. San Francisco picked up road wins over the Cincinnati Bengals and Los Angeles Rams late in the season.

Moving forward, make sure you check out our NFL postseason betting tips.



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