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Week 5 College Football Betting Lines and Analysis – Early Odds for the Top 25

By Dan Vasta in College Football
| September 27, 2021 11:42 am PDT

September is officially in the books, and October football is upon us. The conference games are stepping up in importance, and we will soon be discussing College Football Playoff rankings.

This weekend should be the best one of the entire college football season up to this point. Usually, the final few weeks of the season are full of surprises We will see upsets, and a juggernaut or two always loses or sweats a game out.

Here are the latest odds for Week 5, involving all the Top 25 squads via Sportsbetting.ag.

Early Week 5 College Football Odds

  • No. 5 Iowa (-4) -110 at Maryland (+4) -110
  • No. 13 BYU (-8.5) -110 at Utah State (+8.5) -110
  • Mississippi State (+9.5) -110 at No. 15 Texas A&M (-9.5) -110
  • No. 11 Ohio State (-16) -110 at Rutgers (+16) -110
  • No. 10 Florida (-7.5) -105 at Kentucky (+7.5) -115
  • No. 14 Michigan (+1) -115 at Wisconsin (-1) -105
  • Arizona State (+3) +100 at No. 20 UCLA (-3) -120
  • No. 8 Arkansas (+19.5) -112 at No. 2 Georgia (-19.5) -108
  • No. 7 Cincinnati (-2.5) -115 at No. 9 Notre Dame (+2.5) -105
  • UL Monroe (+34) -110 at No. 16 Coastal Carolina (-34) -110
  • No. 12 Ole Miss (+14.5) -120 at No. 1 Alabama (-14.5) +100
  • No. 3 Oregon (-7.5) -115 at Stanford (+7.5) -105
  • No. 6 Oklahoma (-10.5) -120 at Kansas State (+10.5) +100
  • Indiana (+11) -110 at No. 4 Penn State (-11) -110
  • Boston College (+16) -110 at No. 25 Clemson (-16) -110
  • Western Kentucky (+10) -110 at No. 17 Michigan State (-10) -110
  • No. 22 Auburn (+3.5) -115 at LSU (-3.5) -105
  • No. 18 Fresno State (-10) -110 at Hawai’i (+10) -110
  • Louisville (+7) -110 at No. 24 Wake Forest (-7) -110
  • Louisiana Tech (+19) -110 at No. 23 NC State (-19) -110
  • No. 21 Baylor (+3.5) -104 at No. 19 Oklahoma State (-3.5) -116

The SEC has two Top 25 matchups, with three of the teams hailing from the SEC West. Whenever the top two teams in the country have grueling home games, it is must-watch television. Will we see any upsets?

Many are looking at the matchup in South Bend at Notre Dame. Brian Kelly just became the most decorated winning coach in program history over Knute Rockne.

There’s a lot at stake, the Bearcats are also undefeated with hopes of appearing in the College Football Playoff. There are so many great storylines and great matchups this weekend.

Ole Miss and Lane Kiffin will look to become the first-ever assistant to dethrone Nick Saban. The Crimson Tide haven’t gone up against a dual-threat quarterback like Matt Corral since 2012 with Johnny Manziel.

You can target any of these games right now at the top college football betting sites, but a closer look at the Top 25 showdowns for week five may be a good idea.

No. 5 Iowa at Maryland

  • Iowa (-4) -110
  • Maryland (+4) -110
  • Over 45.5 (-110)
  • Under 45.5 (-110)

Iowa has gone 28-21-1 as a road favorite under Kirk Ferentz, who is in his 23rd season.

Iowa has also gone 17-1 straight up as road favorites since 2015.

The Hawkeyes are a 7-3 run as road favorites, and the Terrapins are 3-3 as home underdogs under Mike Locksley.

No. 13 BYU at Utah State

  • BYU (-8.5) -105
  • Utah State (+8.5) -115
  • Over 58 (-115)
  • Under 58 (-105)

Kilani Sitake has been one of the top coaches in the country this season, but he is 6-8 as a road favorite against the spread.

BYU has gone 5-5 against the spread as road favorites in its last ten games. The Cougars have also won their last three road openers.

Mississippi State at No. 15 Texas A&M

  • Mississippi State (+9.5) -105
  • Texas A&M (-9.5) -115
  • Over 46 (-110)
  • Under 46 (-110)

The Aggies have won two straight in this series and will attempt to break the all-time tie between these two at 7-7. They gave LSU a hard fight last week, and may do so again here.

The Bulldogs are 3-8 in their past 11 games as a road underdog.

Jimbo Fisher is 11-6 as a home favorite at Texas A&M and is 38-28-1 overall. Mike Leach has gone 36-28 as a road underdog and will look to end their current drought over A&M.

No. 10 Florida at Kentucky

  • Florida (-7.5) -110
  • Kentucky (+7.5) -110
  • Over 55 (-110)
  • Under 55 (-110)

Kentucky has gone 3-0-1 against the spread in the past four but recently knocked the Gators off in 2018. Before that victory, the Gators had won 31 consecutive games.

Florida has not lost in Lexington since 1986. To make matters worse, the Gators have gone 6-3-1 against the spread versus Kentucky.

No. 14 Michigan at Wisconsin

  • Michigan (+1) -115
  • Wisconsin (-1) -105
  • Over 43.5 (-110)
  • Under 43.5 (-110)

Jim Harbaugh is 0-11 straight up in the road and neutral-site games against the AP Top 15. He also has never won a game as an underdog with the Wolverines.

Michigan has lost 11 straight games as a road underdog. The last victory was against Northwestern in 2013. Wisconsin has played well at home under Paul Chryst, going 31-9 straight up.

The Badgers didn’t play well last week, of course. Graham Mertz was awful, tossing four picks in a 41-13 loss to the Fighting Irish.

It wasn’t good. Michigan enters as the underdog, but it’s hard to ignore the value bettors could be getting here.

Arizona State at No. 20 UCLA

  • Arizona State (+3) +100
  • UCLA (-3) -120
  • Over 56 (-110)
  • Under 56 (-110)

Herm Edwards has gone 6-3 against the spread as a road underdog. UCLA under Chip Kelly has 18-17-2 against the spread.

Pac-12 after dark is entertaining, but the Bruins are a lowly 2-8 against the spread as home favorites.

No. 8 Arkansas at No. 2 Georgia

  • Arkansas (+19.5) -112
  • Georgia (-19.5) -108
  • Over 48.5 (-110)
  • Under 48.5 (-110)

The Bulldogs have won seven of the past eight meetings against Arkansas. They have failed to cover in four of the past five matchups.

Kirby Smart is 18-11 straight up against the Top 25, but he has gone 12-16 as home favorites.

Arkansas has gone 4-1 as a road underdog under Sam Pittman, and Arkansas has been an underdog in their last 34 SEC games! The last game they were the favorites, was against South Carolina in 2017, a game they lost 48-22.

No. 7 Cincinnati at No. 9 Notre Dame

  • Cincinnati (-2.5) -115
  • Notre Dame (+2.5) -105
  • Over 50.5 (-105)
  • Under 50.5 (-115)

Brian Kelly has gone 38-41-3 against the spread as home favorites.

The Irish have been 22-22 against the top 25 foes during Kelly’s tenure in South Bend. They have covered and won five straight at home with games that had a spread in single digits.

Cincinnati has won three of their last four games when the spread was in single digits.

This should be a tense game, as it features two teams inside the top-10.

UL Monroe at No. 16 Coastal Carolina

  • UL Monroe (+34) -110
  • Coastal Carolina (-34) -110
  • Over 58 (-110)
  • Under 58 (-110)

The Chanticleers are 3-0-2 in their past five home games as a favorite.

We have already seen them favored at home by 27-plus and by 33 points, so a lopsided spread is the expectation these days in Conway.

No. 12 Ole Miss at No. 1 Alabama

  • Ole Miss (+14.5) -120
  • Alabama (-14.5) +100
  • Over 76.5 (-110)
  • Under 76.5 (-110)

Nick Saban is 23-0 against his former assistants, and Lane Kiffin has struggled against solid competition as a head coach, going 0-7 straight up with a 2-5 record against the spread.

Plus, Alabama has won 33 straight home games as the number one AP squad in college football.

Johnny Manziel and Texas A&M in 2012 were the last team to dethrone Saban in Tuscaloosa when they were atop the polls.

This is undeniably one of the best week five college football games to bet on. The only question is how you’ll bet.

No. 3 Oregon at Stanford

  • Oregon (-7.5) -105
  • Stanford (+7.5) -115
  • Over 56 (-110)
  • Under 56 (-110)

David Shaw is 27-20 against Top 25 foes as the head coach of Stanford. The Cardinal were 6-2 as a home underdog in the Shaw era, but they have been solid. Stanford has covered in 10 of their past 12 games as a home underdog.

Oregon has covered in six of the past ten in which they were favorites over Stanford. That’s worth noting, even if their head coach is a bit bonkers.

The Cardinal have upset them three times in those 10, which makes for some thrilling pigskin in Palo Alto this time around.

No. 6 Oklahoma at Kansas State

  • Oklahoma (-10.5) -120
  • Kansas State (+10.5) +100
  • Over 52 (-110)
  • Under 52 (-110)

These past eight meetings have been a nightmare for the Sooners. Kansas State has gone 4-4 outright in the past eight meetings with a 5-3 record against the spread against Oklahoma.

That may not seem impressive, but keep in mind the Sooners have been favored by two touchdowns in six of the eight.

Indiana at No. 4 Penn State

  • Indiana (+11) -110
  • Penn State (-11) -110
  • Over 50.5 (-110)
  • Under 50.5 (-110)

Penn State has dominated Indiana with a 22-2 record. The Hoosiers had the last laugh with their double-overtime victory last season.

The Hoosiers have covered three straights against Penn State with the over-hitting each time.

The Hoosiers have covered in seven of their past eight road games as an underdog. The over seems to be a trend as that has hit five of the past eight.

Boston College at No. 25 Clemson

  • Boston College (+16) -110
  • Clemson (-16) -110
  • Over 47.5 (-110)
  • Under 47.5 (-110)

Clemson needs a victory here in the conference by a lot of points to regain their confidence.

They just fell to N.C. State, which, um, isn’t good.

Dabo Swinney has won 10 games in a row over Boston College, with a margin of victory of 36 points a game before last season.

Clemson has not been a single-digit favorite in an ACC game (excluding Notre Dame last season) since NC State in 2017. This number is lower since they are coming off a loss.

Boston College has lost seven straight at Clemson as an underdog, but did stun them in 2007. BC has covered in four of the past five meetings at Clemson.

Western Kentucky at No. 17 Michigan State

  • Western Kentucky (+10) -110
  • Michigan State (-10) -110
  • Over 60 (-110)
  • Under 60 (-110)

Sparty is 21-33 against the spread as a home favorite since 2011. They have done well against C-USA, going 6-1 against current squads from the conference.

Western Kentucky is 3-0-1 as road underdogs going back to last season.

No. 22 Auburn at LSU

  • Auburn (+3.5) -115
  • LSU (-3.5) -105
  • Over 53.5 (-110)
  • Under 53.5 (-110)

The amount of revenge on the minds of LSU should have a vital role. LSU had a 31-point margin of defeat last season and will be out for revenge after last year’s embarrassing season.

The home team in this rivalry is 18-3 straight up and 14-6-1 against the spread in the past 21 meetings.

No. 11 Ohio State at Rutgers

  • Ohio State (-16) -110
  • Rutgers (+16) -110
  • Over 56.5 (-110)
  • Under 56.5 (-110)

The Buckeyes have won the last two games over the Scarlet Knights by 57 points. They did similar damage against Akron last week.

However, Rutgers has covered both with the overs hitting.

Ohio State is 7-0 in this series and has scored at least 49 points in every game. They look like an obvious bet to win, but will they cover the spread?

Unsure about how to approach spreads? Check out this guide to betting on point spreads.

No. 18 Fresno State at Hawai’i

  • Fresno State (-10) -110
  • Hawai’i (+10) -110
  • Over 63 (-110)
  • Under 63 (-110)

Before losing last season, Fresno State has dominated this series. They have played every season since 1992, and the Bulldogs have won eight of the past nine meetings.

Hawai’i has covered four of their past six home games that they entered as underdogs.

Fresno State has gone 14-8-3 since 2011 as a road favorite.

Louisville at No. 24 Wake Forest

  • Louisville (+7) -110
  • Wake Forest (-7) -110
  • Over 61 (-110)
  • Under 61 (-110)

Wake Forest has been catching fire under Dave Clawson, and they have covered four of their past six games as a home favorite.

Even after covering and winning last week as a slight favorite, Scott Satterfield is 7-10-2 as a road underdog with Louisville.

Louisiana Tech at No. 23 NC State

  • Louisiana Tech (+19) -110
  • NC State (-19) -110
  • Over 55 (-110)
  • Under 55 (-110)

NC State has won ten straight games against the Group of Five. They are 3-0 at home covering the spread this season, but they are 6-0-1 in their last seven home games dating back to 2019.

Louisiana Tech has covered four of their last six games as a road underdog.

Skip Holtz is winless with the Bulldogs against Top 25 competition (0-5), and is 4-15 in his career.

No. 21 Baylor at No. 19 Oklahoma State

  • Baylor (+3.5) -104
  • Oklahoma State (-3.5) -116
  • Over 48.5 (-105)
  • Under 48.5 (-115)

Mike Gundy has had success over the Top 25 before, but he is only 30-38 after their recent win over Kansas State.

Oklahoma State is 1-2 this season as a home favorite, making them 44-30-3 under Gundy.

Baylor has gone 6-5 as a road underdog the last four seasons. Baylor is 5-0-1 against the spread in their past six games as a road underdog.

Final Thoughts on Week 5 College Football Odds

We are approaching October, and college football has been heating up with the Top 25 matchups. This weekend could be the top slate of games to watch all year.

The SEC has its top games before night games, but this will be fun for all fans. It has been years since there have been consistent premier games in the morning and early afternoon. This week has all the best games well before dinner.

It wasn’t long ago that we had premier programs playing many of their games before nightfall. Nowadays, most of those programs aren’t even relevant. Hopefully this weekend we’ll have a few thrillers that come down to the wire.

Hopefully, these updated odds and analyses will help get you on the path to success when making selections.

Enjoy the upcoming weekend, and be sure to have the remote and other screens available to watch multiple games.

For more college football odds and predictions for week five, be sure to check out our sports betting picks.

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