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Top NFL Matchups Sports Bettors Can Exploit in Week 2 (2021)

By Dan Vasta in NFL
| September 16, 2021 5:59 am PDT

The NFL is back and better than ever, and the opening weekend did not disappoint. There were exposed weaknesses by teams in Week 1.

Many coaches took advantage of several matchups they had at their disposal. I looked at some key NFL matchups bettors could exploit last week. Had you gone with my insight, it may have led to some winning wagers.

Week 2 is here, and there are more matchups for squads to take advantage of to come out victorious. Here are the top NFL matchups bettors can exploit in Week 2 at the top NFL betting sites.

Josh Allen vs. Dolphins Defense

If you aren’t aware of the skills Josh Allen has at his disposal, then you’ve come to the right place.

The Buffalo offense was stagnant against the Steelers, but Allen was electric last season against Miami.

Josh Allen vs. Miami Passing Yards Passing TD
2020 Season (Two Games) 641 7

The Bills offense will get back to producing on the offensive end, and the 2020 production will return to form for this matchup.

Stefon Diggs was remarkable as a pass-catcher last season, and he had a successful debut in Week 1 against Pittsburgh. Stefon Diggs will have opportunities in this one, but Allen has been able to drop the ball in the bucket on deep connections going back to last season.

The Dolphins defense had some issues defending Mac Jones, who does not have the same weapons that the Bills possess.

Despite this matchup being on the road, Buffalo won this division last season thanks to sweeping the entire AFC East.

Allen is known for his arm strength, but his dual-threat ability makes him impossible to defend. The Dolphins would love to start the season 2-0, but defending Allen will be one of their biggest challenges of the season.

Cardinals Pass Rushers vs. Vikings Offensive Line

Chandler Jones was unstoppable in the season opener against Taylor Lewan and Tennessee.

Jones tallied five sacks and was a wrecking crew for Arizona.

The number of mixed youngsters and veterans should allow for success.

J.J. Watt played well in his Arizona debut, but Jones stole the show. He was injured last season, and the defense suffered. Kliff Kingsbury is a coach that entered the season on the hot seat, but there arguably wasn’t a better win in Week 1 than Arizona thumping Tennessee.

Minnesota could be sitting ducks when they are preparing for the sensational pass rush of Arizona. Kirk Cousins is not capable of breaking many tackles. The slightest bit of pressure will put him on his back.

The offense of the Vikings fell behind the sticks too often against the Bengals. Dalvin Cook is one of the better home-run hitters in the game. As long as Cook can get going, Minnesota could offset the Arizona pass rush. If not, it could be a disappointing 0-2 start to the season.

Aaron Rodgers vs. Lions Defense

The Packers were comical in their season debut against the Saints. The entire offense was a disaster against New Orleans.

Aaron Rodgers and the passing attack struggled to move the ball past mid-field, and if there was ever a get-right game for Green Bay, this was it.

Monday Night Football at Lambeau Field against an iffy Detroit defense is the cure for all struggles.

The Lions staged a comeback but still came up short against San Francisco. Green Bay failed to get anything going in their run game since they fell way behind on the scoreboard.

Davante Adams was the top wide receiver in football last season, so look for him to get peppered by Rodgers in this matchup.

Detroit lost their star defensive back Jeffrey Okudah for the season.

The Lions may try to double Adams, allowing role players like Robert Tonyan, Allen Lazard, or Marques Valdez-Scantling to shine.

Rodgers is coming off the fewest points scored for a reigning MVP in the first game of the subsequent season in NFL history. Getting held out of the end zone and settling for three points for the entire game was an albatross.

Taking advantage of the upside and bouncebackability for the Packers is worth a look in this favorable matchup.

David Montgomery vs. Bengals Defense

Montgomery was the number two rusher from the season-opening weekend in the NFL.

The Chicago rusher ran with a physical style that made it challenging for the Rams to slow him down. Monty was popping off solid yardage of five-plus yards on most snaps.

Here’s his final stat line from week one.

  • 16 rushing attempts
  • 108 rushing yards
  • 6.8 YPC
  • 1 TD

The Bengals had their issues slowing down Dalvin Cook last week. The Bears should feature the second-year player out of Iowa State. They have abandoned the run often under Matt Nagy, but they should pound the ground game against a mediocre Cincy defense.

Andy Dalton was under duress all night against the Rams. The Bengals won’t bring the heat quite like Aaron Donald or Jalen Ramsey. However, having a running game will allow the quarterback to stay upright.

Dalton and the passing attack have too much pressure on them, and they should try to get as much production from the running game as they can in this matchup against the Bengals.

Cooper Kupp and Robert Woods vs. Colts Secondary

Matthew Stafford was dazzling against the Bears in his Rams debut. The ability to hit a home run connecting with Van Jefferson and Cooper Kupp was impressive. There is no stopping the Rams passing attack because they have a bevy of weapons.

Kupp and Robert Woods are two of the better route runners in the league. They should feast on a Sean McVay offense that has upside.

While the expectations are lofty after acquiring Stafford, there are plenty of pieces for the Rams to become a Super Bowl contender.

Woods hauled in a touchdown late in the fourth quarter, but Kupp nearly scored twice against Chicago. The dynamic LA duo will have success in most weeks this season. Jefferson, Desean Jackson, and Tyler Higbee will put together solid production with Stafford under center.

Kupp and Woods will be moving around on most snaps, and they will wreak havoc on the Indianapolis secondary. Tyler Lockett hauled in two touchdowns in the Seattle victory over Indianapolis, and we will likely see a few more deep connections in this matchup.

Looking Ahead to Week 2 in the NFL

There are many other NFL matchups to dissect and keep your eyes on for Week 2.

Kansas City going on the road to Baltimore will be the headliner, and you should keep in mind that Patrick Mahomes has been remarkable in September. He improved his career record to 11-0 in September, but going on the road won’t limit the Kansas City offense.

The Atlanta secondary may have issues defending Tom Brady. There are dozens of matchups that we could spend hours over. Look at some advantages for the upcoming week and jot down the ones that could prove to be the difference between winning and losing your bets.

These are the top matchups to help you win your wagers for the upcoming Week 2 slate of games.

Whether you use these week two NFL matchups to your advantage or not, I wish you luck. Get ready for week two with a look at some more NFL betting content below.

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