Top Games to Bet on in Week 5 of the 2021 College Football Season

By Dan Vasta in College Football
| September 30, 2021 11:20 am PDT

The slate of games in Week 5 is going to be the best we see all season. The bettor out there looking for electric atmospheres where games matter may want to check in this weekend.

College football is the best sport in the world to follow during the regular season due to the games mattering. Even with a four-team playoff, these games are vital. Divisions have several crucial matchups.

Here are the top college football games to bet on for Week 5.

No. 8 Arkansas vs. No. 2 Georgia

  • Arkansas (+18.5) -105
  • Georgia (-18.5) -115
  • Arkansas to Win (+700)
  • Georgia to Win (-1100)
  • Over 48 (-110)
  • Under 48 (-110)

This SEC showdown is an early kickoff on Saturday that has plenty of CFP aspirations involved.

Everybody said in the preseason, Arkansas would come up short reaching the postseason. Their schedule was the most challenging in America for some. Here we are a month into the season, and the Razorbacks are already in the Top 10.

Sam Pittman is the top coach in America to root on. He has shown his emotions ever since he took the job in Arkansas.

He also knows how to have fun with his team and attracts folks on social media going back to his days with Georgia.

Kirby Smart at Georgia is another coach that is attempting to get over the hump. The amount of talent he has had at his disposal for the past few years has been absurd. It is even crazier to think they have not won a national title since 1980.

Arkansas might have the goods to crack the top five in the SEC West. The Bulldogs could put an end to their natty title drought. Plus, many felt Georgia lacked enough offensive pieces to be a title contender.

Arkansas has been an underdog in 34 consecutive SEC games. ARK-UGA currently are Top 10 teams, and the Razorbacks have turned their program from the basement dweller that they were two seasons ago to a bonafide SEC squad.

Something has to give in this matchup, and the spread is outrageous for a Top 10 matchup. Surprisingly, we have seen higher point spreads over the years between Top 10 teams.

We saw Alabama favored by 18 points at home against Texas A&M in 2016. Then, we had FSU as a three-touchdown favorite over Miami in 2013.

Still, this SEC clash is the perfect game to start your Saturday morning.

No. 12 Ole Miss vs. No. 1 Alabama

  • Ole Miss (+14.5) -116
  • Alabama (-14.5) -104
  • Ole Miss to Win (+460)
  • Alabama to Win (-600)
  • Over 79 (-112)
  • Under 79 (-108)

The point total on this matchup is going to make for highly entertaining television. The second time slot of the day in the middle of the afternoon is going to be riveting.

Matt Corral has the opportunity to make his case for the Heisman Trophy in Tuscaloosa. There may not be a better game to watch this season at this point. The Rebels and Lane Kiffin have an offense that seems unstoppable.

The Rebels lead the nation at 52.7 points per game, and the Crimson Tide is fourth at 46.5 points per game.

These are two of the best teams in the country. Forget the rankings because Ole Miss showed in their bowl victory over Indiana last season that they were arriving.

They had an abysmal defense for most of the 2020 season, but they have improved on both sides of the ball for this thrilling potential SEC game of the year.

Bryce Young could throw his name into the Heisman race if he performs well in a victory. The ability to avoid turnovers is vital. The point total could be high even if there are turnovers, but the team that wins the battle will likely come out victorious.

Nick Saban is 23-0 against his former assistants, and Lane Kiffin is one of the few that has seemingly saved face by avoiding being blown out. Most teams don’t stand a chance against Nick Saban.

He is 83-8 atop the AP Poll while being favored in 156 of the last 157 games. The 92 wins against ranked foes by Saban is the most in college football history.

Alabama has won 35 straight games at home when ranked atop the AP Poll. If there was a team capable of dethroning them from the top of the mountain, it is the Rebels.

No. 14 Michigan vs. Wisconsin Odds

  • Michigan (+1) +105
  • Wisconsin (-1) -125
  • Michigan to Win (+110)
  • Wisconsin to Win (-130)
  • Over 43.5 (-110)
  • Under 43.5 (-110)

The Michigan head coach has never won a game as an underdog with the Wolverines (0-11). Seriously, nobody is talking about it much since the wins have not been there in games they are favored.

The Wolverines have not won a Big Ten title since 2004, and they fell on their faces competing for national crowns. They will be chasing their first national title since 1997.

Jim Harbaugh needs to win this game to shut the naysayers up. The spread has been changing every day of the week multiple times. The Wolverines might end up as underdogs in this Big Ten tilt.

The Maize and Blue expect to compete with every team in America. They snuck out a victory over Rutgers last week, but this game will be a fun one to bet on due to the aftermath. Michigan will continue to ascend in the polls and the rankings if they win this one in Madison.

Trips to East Lansing and Happy Valley will be challenging before they host the Buckeyes. None of that matters if they lose to the Badgers.

Wisconsin already has been a disappointment with two losses. They had hype to have a Top 10 type of season, and some even thought they had a shot to be a dark horse CFP squad.

They are not out of the Big Ten title race in the West division. Other than Iowa, no team has looked overly impressive, and the Hawkeyes still have to head to Camp Randall Stadium. That is where Michigan will be this weekend, and many believe they have the goods to walk out victorious.

The rushing attacks are two of the better ones in the country. Michigan headed into last week as the top-ranked rushing offense in the FBS. They have dropped to fifth in the nation, and Wisconsin is at No. 33.

This Big Ten clash is likely to come down to the wire, and Gus Johnson may lose his mind in this game. Neither team wants to get pass-happy against stellar defenses.

Enjoy this early kickoff, and be sure to have a second screen nearby to check on your other wagers.

No. 7 Cincinnati vs. No. 9 Notre Dame Odds

  • Cincinnati (-2.5) -104
  • Notre Dame (+2.5) -116
  • Cincinnati to Win -118
  • Notre Dame to Win -102
  • Over 50.5 (-105)
  • Under 50.5 (-115)

The Bearcats and the Fighting Irish might be the underrated game of the week despite both being in the Top 10. The last national championship was in 1988 for Notre Dame, but they have appeared in the CFP twice in the past three seasons.

Winning this game in South Bend could go a long way in terms of having a shot at getting back to the CFP.

The Irish have become a top five-ish program in the CFP era next to Alabama, Clemson, Georgia, Ohio State, and Oklahoma.

Consistently performing at a Top 10 level will only keep the Golden Domers in national title contention. There are new contenders these past few years, and Cincinnati has emerged. A victory over the Irish could propel them towards becoming a legitimate contender to appear in the 2021-22 CFP.

Luke Fickell is a potential candidate to take over USC, and he certainly has been flawless in the American Athletic Conference. Their non-conference ability is what can separate them from the pack.

If other squads try to throw their hat in the CFP ring, they will have to get behind the Bearcats.

The Pac-12 and Big Ten are hopeful of having an undefeated team reach the CFP, but the winner of this matchup could put that statement to the side. To have a matchup between two outside the Power Five in terms of conferences will make for a great game.

No. 10 Florida vs. Kentucky Odds

  • Florida (-8) -115
  • Kentucky (+8) -105
  • Florida to Win -325
  • Kentucky to Win +270
  • Over 56 (-110)
  • Under 56 (-110)

The Gators have dominated this series, having won 31 in a row up until 2018. The last victory in Lexington for the Cats over the Gators was in 1986!

This late evening matchup is likely to come down to the wire due to offenses that rely on the ground game. The battle at the line of scrimmage will be a war. The number of hog mollies in the trenches will decide this SEC East matchup.

Chris Rodriguez for Kentucky and Malik Davis for Florida are the top backs on the rosters. Emory Jones at quarterback leads UF in rushing, but his decision-making is what could decide this matchup.

The Wildcats and Gators have had some close contests at Kroger Field in recent memory. This SEC game should come down to the wire.

I love the atmosphere in the SEC, and if Florida wants to stay in the hunt for the CFP and the SEC East, this will be a must-win game.

Look Ahead to College Football Week 5 Games

The amount of early morning and afternoon games might be the best we have ever witnessed. The SEC alone has three premier matchups. Most weeks, there may not even be one game between Top 25 teams early on, and this week there are several to watch simultaneously.

There are lots of options to select from this weekend, but be sure to choose wisely. Enjoy the weekend, which is sure to be the best of the entire season.

For more college football news stay tuned to our picks page.



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