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Top Daily Fantasy Football Lineups for NFL Week 16 (2020)

| December 23, 2020 5:08 am PDT
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If you were looking for daily fantasy football advice last week, my NFL DFS lineups didn’t disappoint.

Ideally they were combined together and included last second chalk like Leonard Fournette and Tony Pollard, but I do tend to push this post out early in the week.

Despite that, I was all over Jalen Hurts, while I also vouched for Mark Andrews, Russell Gage, Keke Coutee, and Derrick Henry.

I loved Jeff Wilson Jr. and Gus Edwards prior to news coming out, so you honestly could have pivoted off of them to Pollard/Fournette with zero effort. If you did that, you may have won big last week.

Hopefully I can keep handing out top shelf advice. Let’s see the teams I like as I break down my favorite NFL DFS lineups for week 16.

Week 16 Daily Fantasy Football Advice

This is a strange slate, as a lot of huge names are playing on Friday, Saturday, Sunday night, and Monday.

That means you need to work a bit harder to fall in love with your daily fantasy football lineups, but I think it’s doable.

Like always, the first step should be to check out the latest betting lines. You can start with my breakdown of the early week 16 NFL odds, but I’ll also highlight the best NFL DFS game environments right here.

  • Falcons vs. Chiefs (54 total)
  • Broncos vs. Chargers (48.5)
  • Eagles vs. Cowboys (50)

Some of the best games are not on the Sunday main slate, so this will certainly be interesting. There are a few other games with totals around 46 and 47, but they are likely going to be defensive battles, or they’re potential blowouts.

That doesn’t mean you can’t use players from those spots, but the three games listed above feel like the best stacking opportunities.

You’ll also want to keep tabs on any big injury news. Raheem Mostert playing, Ronald Jones Jr. not playing, and Ezekiel Elliott being a random late scratch completely changed how DFS gamers operated last week.

Obviously going in, you didn’t have Fournette or Pollard on your radar. If you faded them, you probably didn’t do so well.

For week 16, the main injuries you’ll want to keep tabs on involve the following players.

  • Christian McCaffrey
  • James Robinson
  • Ezekiel Elliott
  • Antonio Gibson
  • Julio Jones
  • Tyler Boyd
  • Eric Ebron

It’s also worth noting that Clyde Edwards-Helaire is done for the regular season, and Cam Akers will not play this week.

Their absences open things up quite a bit, as Le’Veon Bell and whoever the Rams roll with (probably Darrell Henderson) look very interesting.

All of this is fluid, as I’m handing out my week 16 NFL DFS lineups on a Tuesday. Since it’s the holidays, you’ll have to adapt to any changes and combine any news with my squads as you see fit.

NFL DFS Cash Lineup for Week 16

  • QB: Patrick Mahomes – Chiefs ($8.5k)
  • RB: Darrell Henderson – Rams ($4.5k)
  • RB: Giovani Bernard – Bengals ($4.8k)
  • WR: Tee Higgins – Bengals ($4.7k)
  • WR: CeeDee Lamb – Cowboys ($5.3k)
  • WR: Keke Coutee – Texans ($5.4k)
  • TE: Travis Kelce – Chiefs ($8.5k)
  • FLEX: Le’Veon Bell – Chiefs($5.8k)
  • DEF: Cincinnati Bengals ($2.3k)

There is a ton of chalk here, but all you need to do is cash, so you shouldn’t mind eating a lot of it.

Stacking Chiefs in some regard just makes too much sense this week, and they start off my week 16 NFL DFS picks.

Do you have to pay up for all of them? No, and honestly, in GPPs you can get creative with who you fade, and which cheap options you use.

I’d try to run it back with a Falcons play in tourneys, too. I don’t care so much about correlation in cash games, of course.

Mahomes is a god, he’s got a great matchup, and quarterback is fairly thin this week. Jalen Hurts ($7k) is the obvious pivot and saves $1.5k, but Mahomes is just safer. You can pair him with Tyreek Hill or Travis Kelce (or both), but I prefer the latter due to tight end being abhorrent this year.

Elsewhere, it feels like a pretty good week toe at the running back chalk. In tourneys, look elsewhere at least once or twice, but in cash games I’ll gladly roster Gio, Bell, and Henderson.

Henderson is probably a lock in all formats. He’s simply too cheap and is going to have a big role. Same with Gio, who is still pretty risky, but has a great matchup and came to life in week 15.

Bell is a calculated fade in tourneys, but 15+ touches in this Chiefs offense isn’t anything to scoff at. He gets you relatively cheap exposure to the best NFL DFS environment on this slate, too.

There are a lot of stud wide receivers to consider, but there’s also a ton of value at the position.

CeeDee Lamb and Tee Higgins are viable at these prices no matter what, but both get huge boosts if guys like Michael Gallup and Tyler Boyd are out.

I’ll punt defense, one way or the other. Cincy stands out because they’re cheap, they looked super motivated in a huge upset win on Monday night, and Houston gives up sacks.

They’re a fine punt, but there are several options to consider at a position that just isn’t worth spending on.

NFL DFS GPP Lineup for Week 16

  • QB: Drew Lock – Broncos ($5k)
  • RB: Miles Sanders – Eagles ($7k)
  • RB: Darrell Henderson Jr. – Rams ($4.5k)
  • WR: Tyreek Hill – Chiefs ($9k)
  • WR: Cedrick Wilson – Cowboys ($3k)
  • WR: Calvin Ridley – Falcons ($8.5k)
  • TE: Hayden Hurst – Falcons ($3.4k)
  • FLEX: Jonathan Taylor – Colts ($7.3k)
  • DEF: Cincinnati Bengals ($2.3k)

You can play it safe with Mahomes or Hurts at quarterback, but in tournaments, I love the idea of a total punt. Drew Lock is just too cheap, as he gets a beatable matchup against the Chargers.

He wasn’t good last week, but Lock put up 20 fantasy points the last time he faced L.A., and he tossed four scores just two games ago. I just can’t pass on the value and upside here, plus it opens up so much cash when compared to the two safest plays at the position.

Lock heads my top NFL DFS sleepers for week 16.

I am pretty comfortable with eating all of the same chalk at running back, but for this lineup, the only cash game-like back I feel I need is Henderson. You can get cute and roster Malcolm Brown here as well, but Henderson just feels like the auto play of the week.

In tourneys, I will definitely think about fading Bernard and Bell, though. The Chiefs get almost all of their production through the air, and it’s certainly not wild to think Bernard could fail.

Instead of punting running back, I’ll pay for Miles Sanders and Jonathan Taylor. Both of these guys have monster upside, and there’s a chance both could end up being fairly low-owned.

For GPPs, I will make Tyreek Hill a priority over Travis Kelce. Both should be popular, but I really like Hayden Hurst as a cheap way to gain access to that Falcons vs. Chiefs game.

Hill is Hill, and then you can run it back again with Ridley. As I said, how you stack that game is open for debate, but I think you’ll need exposure to this hammer game, one way or another.

I have no qualms about using the Bengals defense again here, just to make the money work. Ditto for Cedrick Wilson, who could be an amazing punt if Gallup is out.

Just keep an eye on the situation, as even Noah Brown could factor into things.

Those plays probably make this all come together the most, but as is the case with any NFL DFS lineups you make, you’ll always want to be sure the guys you’re rostering make total sense.

In other words, if questionable guys play or sit out, you need to be ready to adapt and make changes.

Week 16 NFL Betting

Like I’ve said in past weeks, there can be a direct correlation in how I build my daily fantasy football lineups, and how I bet on the NFL.

Last week the Eagles stood out as an upset play, and that was largely built around my love for Jalen Hurts. That nearly panned out.

I was also very high on the Ravens and felt they’d have no troubling beating (and covering) against Jacksonville, and that was very much the case.

Correlations don’t always pan out or even necessarily exist, but I think you can still find some going into week 16.

When looking at my week 16 NFL DFS lineups, I think the main bet that makes the most sense is the Over in that Chiefs game. Nothing else feels quite as concrete in relation to my daily fantasy teams this week, but I certainly have plenty of advice to hand out.

For more week 16 NFL betting help, hit up the links below.

Noah Davis
Noah Davis

Noah Davis is one of the more diverse writers at GamblingSites.com. Like many of his colleagues, he's a huge fan of both football and basketball. But he also writes about box office records, TV show prop bets, DFS, and all kinds of other subjects.

When it comes to the NFL, Noah's favorite team is the Cleveland Browns. He enjoys cheering them on with his wife and daughter.

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