Odds, Picks, and Predictions for the 2022 UEFA Champions League Semi-Finals

| April 14, 2022 12:30 pm PDT
UEFA Champions logo, Liverpool and Villarreal manger, soccer players

The bookmakers have updated their 2022 Champions League odds ahead of the semi-finals.

As we enter the business end of the season, Liverpool, Manchester City, Real Madrid, and Villarreal are the only teams that can still dream of lifting the famous trophy in Paris on May 28.

Having won a mammoth 19 UCL titles between them, Real Madrid (13) and Liverpool (6) are in familiar territory. The Spanish powerhouse clinched a famous three-peat between 2016 and 2018 before the English giant reclaimed the crown in 2019.

On the flip side, Man City and Villarreal have the chance to create history. Can Pep Guardiola’s star-studded squad finally fulfill its potential? Or will Villarreal secure an unlikely triumph against all the odds?

Speaking of odds, let’s kick things off by checking out the latest Champions League winner odds. I will then look at all four teams before sharing my Champions League predictions for the semi-finals and beyond.

Latest UEFA Champions League Winner Odds (2022)

Manchester City+125
Real Madrid+500

According to the 2022 Champions League odds at Bovada, there is almost nothing to separate Liverpool and Man City. Although the Reds are marginal favorites to secure the silverware, the Cityzens are right alongside their EPL rivals.

The bookies are giving Real Madrid a fighting chance of clinching the title. But if Carlo Ancelotti’s men want to get their hands on the trophy, they will need to get past Man City in the semi-finals.

Unsurprisingly, Bovada views Villarreal as the rank outsider. The “Yellow Submarine” is a minnow compared to the other three clubs, so Liverpool is expected to sink the underdog in the semi-finals.

Now that we’re up to speed with the latest UCL winner odds, it’s time to assess the 2022 Champions League SF odds.

2022 Champions League Semi-Finals Odds and Fixtures

The semi-finals begin on Tuesday, April 26, with Man City hosting Real Madrid. On Wednesday, April 27, Liverpool welcomes Villarreal to Anfield for the first leg of their clash.

The second legs are scheduled to take place on May 3 and 4.

Here are the Champions League odds for the semi-final’s first legs. As the semi-finals draw nearer, keep an eye on the top soccer betting sites to find prices for the second legs and other markets.

  • Manchester City (-190) vs. Real Madrid (+475)
  • Liverpool (-360) vs. Villarreal (+900)

As you can see, the home teams are favored to dominate the first legs.

Despite Real Madrid’s UCL history and current form, the bookies believe Man City should gain a first-leg advantage. Meanwhile, Liverpool is heavily favored to get the better of Villarreal on home soil.

That’s the 2022 Champions League semi-finals odds covered. Before we get to my Champions League picks and predictions, we need to look at the teams.

Can Liverpool Clinch a Seventh Champions League Crown?

Liverpool badge
  • Liverpool’s Odds to Win the Champions League: +125
  • European Cup/Champions League Titles: 6
  • Last Season: Quarter-Finals

Jurgen Klopp’s boys have played a whopping 51 games in all competitions this season. Remarkably, they have tasted defeat on only three occasions. That tells you everything you need to know about the mentality of this team.

The Merseysiders find themselves a solitary point behind Man City in the Premier League table, having lost just two of their 31 games. Not only are they the top scorers in the EPL, but they also boast the second-best defensive record.

Liverpool qualified for the knockout phase in the Champions League with a 100% record before dispatching Inter Milan and Benfica to reach the last four.

Mohamed Salah (28 goals), Diogo Jota (21 goals), and Sadio Mane (16 goals) have been immense across all competitions this season, feeding off the creativity of Trent Alexander-Arnold (18 assists) and Andrew Robertson (14 assists).

Meanwhile, newcomers such as Luis Diaz and Ibrahima Konate provide the strength in depth required to go deep into competitions and win silverware.

The Reds have already won the EFL Cup this year and look set to push Man City all the way in the EPL title race. With a favorable semi-final clash against Villarreal coming up, they are in pole position to add a seventh UCL crown to their collection.

Will Man City Finally Break Their UCL Hoodoo?

Man City badge
  • Man City’s Odds to Win the Champions League: +125
  • European Cup/Champions League Titles: 0
  • Last Season: Runner-Up

Man City came through a grueling test against Atletico Madrid to reach the semi-finals. Atletico gave Guardiola’s men a serious run for their money, but the English champions battled to seal a 1-0 aggregate victory.

In recent years, the Cityzens have dominated the EPL, claiming three of the previous four titles. If they win their remaining games this season, they will secure a fourth triumph in five years.

However, they always seem to fall short in the Champions League. Following three consecutive quarter-final exits between 2018 and 2020, they finally reached their first UCL final in 2021 – only to fall to Chelsea in the showpiece.

As far as Betway’s 2022 Champions League odds are concerned, Man City’s chances of lifting the trophy are almost identical to Liverpool’s. But while the Merseysiders have the history, Guardiola’s men have yet to end their UCL curse.

With world-class superstars like Kevin De Bruyne, Joao Cancelo, and Ruben Dias littering the Cityzens’ squad, it is surely a matter of whether they will claim the silverware that has eluded them for so long.

But can they get past the mighty Real Madrid?

Is Real Madrid Ready to Claim Another European Title?

Real Madrid badge
  • Real Madrid’s Odds to Win the Champions League: +500
  • European Cup/Champions League Titles: 13
  • Last Season: Semi-Finals

In all honesty, I’m shocked that Real Madrid’s odds of winning the UCL are up at 7.00. Granted, the Spaniards must defeat Man City to reach the final. But they are more than capable of doing that.

Los Blancos claimed a dramatic 5-4 aggregate win against Chelsea in the quarter-finals, thanks mainly to a 3-1 victory at Stamford Bridge. Time after time, they find a way to reach the latter stages of this competition.

As the table below details, Real Madrid is the undisputed king of European soccer. The iconic club has clinched a colossal 13 UCL titles over the years, including four in five seasons between 2014 and 2018.

Club Titles
Real Madrid 13
AC Milan 7
Bayern Munich 6
Liverpool 6
Barcelona 5

Of course, soccer is a team game. But Karim Benzema has tried his best to create a one-person team this season, not in a bad way! Across 38 games in all competitions, the lethal French forward has bagged an outrageous 38 goals and 13 assists.

If the early 2022 Ballon d’Or odds are to be believed, then Benzema has to be included in the conversation when it comes to discussing players who could win the Ballon d’Or in 2022.

On top of that, Vinicius Junior (17 goals, 17 assists) has established himself as one of the top talents in world soccer. You cannot write off Real Madrid with Benzema and Vini Jr in red-hot form when making your UEFA Champions League predictions.

Could Villarreal Upset the 2022 Champions League Odds?

Villarreal badge
  • Villarreal’s Odds to Win the Champions League: +2000
  • European Cup/Champions League Titles: 0
  • Last Season: N/A

While Madrid’s current metro area population is around 6.7 million, the small town of Villarreal has a population of just over 50,000 people. Just let that sink in for a second.

Sure, UCL titles are not won based on the size of cities and towns. But those numbers should indicate the gulf in stature between Villarreal and the other semi-finalists.

That said, the Yellow Submarine should not be taken lightly. Led by former PSG and Arsenal manager Unai Emery, this spirited team has already beaten European powerhouses such as Manchester United, Juventus, and Bayern Munich this year.

Let’s not forget that the Spaniards booked their spot in this season’s Champions League by winning last year’s Europa League. That makes their recent achievements even more impressive.

In 2021, Emery claimed his fourth Europa League title as a manager. Having guided Sevilla to three successive triumphs between 2014 and 2016, the experienced coach knows how to win silverware.

Underestimate Villarreal at your peril. They may not be the most popular of UEFA Champions League picks, but they are only a couple of positive results away from producing the shock of the century.

Champions League Picks for the Semi-Finals

It’s time for my semi-final Champions League picks. Having taken an in-depth look at all four sides, I’m ready to make some Champions League predictions for the semi-finals.

Despite Real Madrid’s unrivalled UCL reputation, I’m backing Man City to reach the final. Of course, Benzema could make singlehandedly fire his team to glory. But Los Blancos’ overreliance on their talisman is a cause for concern.

By contrast, Man City arguably boasts the strongest squad in world soccer. If one or two players fail to hit their usual heights, Guardiola can call upon a host of world-class stars to get the job done.

  • Manchester City vs. Real Madrid Pick: Manchester City to Qualify

Don’t get me wrong; I would love to make a case for Villarreal here. At the end of the day, though, I can’t see the Spanish minnow overcoming the English giant.

Granted, Emery’s boys have already knocked out Juventus and Bayern Munich. But Liverpool is on a different level from those teams. For that reason, I fully expect the Reds to punch their ticket to the final.

  • Liverpool vs. Villarreal Pick: Liverpool to Qualify

2022 Champions League Predictions – Who’ll Lift the Trophy?

My Pick: Liverpool (+125)Bet on Liverpool at Bovada

If my semi-final Champions League picks come to fruition, then Liverpool and Man City will meet each other in the final at the Stade de France on May 28.

Few would argue that Liverpool and Man City are not the best teams on the planet right now. Not only are they separated by just a single point in the EPL table, but they are also joint favorites to win the UCL.

Ultimately, both sides deserve to lift the trophy. But having considered everything, my 2022 Champions League pick is Liverpool.

Why? Because Klopp’s team knows what it takes to go all the way.

Following their UCL triumph in 2019, the Merseysiders have the know-how to deal with the occasion and get over the line.

On the flip side, Man City has yet to taste European success. I’m sure it’s only a matter of time before the Cityzens get their hands on the elusive trophy, but it feels like Liverpool has the upper hand.

For more content like this, head over to our soccer blog. You can also find more Champions League predictions and betting tips in the UCL picks section of our site.

Ben Morris
Ben Morris

Ben is a sportswriter and tipster who specializes in soccer. Currently based in the UK, he has traveled all around the world watching – and betting on – his beloved sport.

Alongside his regular soccer content, Ben publishes blogs and picks for cricket, Formula 1, Aussie rules, darts, and various other sports.

Ben is a diehard fan of Nottingham Forest and England, so he hasn’t had much to cheer about in recent years!

More Posts by Ben Contact Ben



September Casino of the Month
Welcome Bonus 250% up to $5,000
Back to top