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NFL Betting Odds and Breakdown for Week 10 of the 2021 Season

By Dan Vasta in NFL
| November 8, 2021 9:44 am PDT

The Week 9 slate was chaotic with all the upsets that went down. We witnessed four division winners and a handful of playoff contenders fall victim to the upset bug.

Even the Rams lost at home to the Titans, so no favorite was safe. The NFL Week 9 favorites only went 5-7 on Sunday.

To make sense of it all heading into Week 10, here are your top odds and breakdowns as we have officially reached past the halfway point of the season.

Early NFL Betting Odds for Week 10

  • Ravens (-7) -110 vs. Dolphins (+7) -110
  • Jaguars (+10.5) -120 vs. Colts (-10.5) +100
  • Browns (+2.5) -110 vs. Patriots (-2.5) -110
  • Falcons (+9) -110 vs Cowboys (-9) -110
  • Bills (-13) -110 vs Jets (+13) -110
  • Saints (+2.5) +100 vs. Titans (-2.5) -120
  • Buccaneers (-9.5) -120 vs. Washington (+9.5) +100
  • Lions (+9) -110 vs. Steelers (-9) -110
  • Vikings (+2.5) +100 vs. Chargers (-2.5) -120
  • Panthers (+10) -110 vs Cardinals (-10) -110
  • Seahawks (+6) -110 vs. Packers (-6) -110
  • Eagles (+2.5) -103 vs. Broncos (-2.5) -117
  • Chiefs (-3) -105 vs. Raiders (+3) -115
  • Rams (-3) -120 vs. 49ers (+3) +100

For all your Week 10 updates, you can check them at SportsBetting.ag. The pricing is some of the best you will find among all the sportsbooks for the best value.

There have been plenty of chalk outright winners these past few weeks among favorites laying double-digit points, but this is a week that features more competition.

The headliners are the Sunday and Monday night clashes on national television. The AFC West and NFC West are the top divisions in football. The AFC North might be right there, but the west coast has been flexing their muscles as of late.

The Chiefs will be desperate to get past the Raiders in a divisional clash that could decide the division and a playoff spot. We will see more desperation when San Francisco hosts the LA Rams.

Los Angeles (NFC) is looking for the top seed in the NFC, but they need to handle their division first.

Baltimore Ravens vs. Miami Dolphins

  • Ravens (-7) -110
  • Dolphins (+7) -110
  • Over 47.5 (-110)
  • Under 47.5 (-110)

The Dolphins have struggled overall, and they are in line to receive a top pick in the upcoming 2022 NFL Draft. Lamar grew up in Florida and will look to turn back the clock on Thursday Night Football.

The Ravens are 5-4-1 as road favorites against the spread in their past ten games. Baltimore is 8-2 straight up in those games, but Miami has been respectable as well as home underdogs.

The Dolphins are 2-5 straight up in their past seven as home underdogs. Miami is 6-4 ATS in their last ten home games as an underdog.

As Lamar makes his push for an MVP season, the Ravens will look to continue their winning ways.

Jacksonville Jaguars vs. Indianapolis Colts

  • Jaguars (+10.5) -120
  • Colts (-10.5) +100
  • Over 48 (-110)
  • Under 48 (-110)

The Jaguars come in with all the momentum in the world. Urban Meyer and Trevor Lawrence upset the AFC favorites at home. Their defense proved to be the difference as their young stud Josh Allen was sacking Buffalo signal-caller Josh Allen to confuse all those non-die-hards.

James Robinson (heel) could be returning for this matchup, but the offense made way with the slower and methodical plodder in Carlos Hyde. Jacksonville only totaled 218 yards of offense, but they made the Buffalo offense look like a junior varsity squad.

Turning Buffalo over three times and self-inflicted wounds with penalties played a vital role in the upset victory. Indianapolis had both Carson Wentz and Jonathan Taylor go bonkers against the Jets.

If they continue to produce their current numbers, they will stay in the playoff hunt all season.

This total and spread seem to be high, but it is challenging to trust this Jaguar offense. Going on the road after they are feeling amazing often brings a letdown.

Cleveland Browns vs. New England Patriots

  • Browns (+2.5) -110
  • Patriots (-2.5) -110
  • Over 44.5 (-110)
  • Under 44.5 (-110)

The Browns played their first game in their current tenure without Odell Beckham Jr., and they still look lackluster. Baker Mayfield looks cooked, and the injuries seem to have caught up with Cleveland.

Mayfield entered Week 9 with only 21 completions of 20-plus yards on the season. To make matters worse, the Browns have been one of the more inconsistent teams in the league.

The one silver lining for them is the recent struggles of the Patriots as home favorites. New England has failed to cover in four of their past six games as the home favorites. They are 2-4 outright, which makes Cleveland a live underdog in this likely defensive slugfest.

Kareem Hunt (calf) has not been able to stay healthy, and Nick Chubb has not been catching fire as of late. They may need Chubb and D’Ernest Johnson to take over and dominate the line of scrimmage.

In a crowded AFC playoff picture, these two are desperate for victories. Both divisions have some of the better teams in football, making this one the top bubble game of the weekend.

Atlanta Falcons vs. Dallas Cowboys

  • Falcons (+9) -110
  • Cowboys (-9) -110
  • Over 52 -110
  • Under 52 -110

The NFL truly is a spectacle. Every weekend, we have seen finishes and upsets that mostly nobody saw coming. Week 10 has the perfect matchup to discuss.

Atlanta is in the playoff discussion at 4-4, thanks to an upset victory at New Orleans. We have seen the Falcons cover and win outright on heavy spreads.

Dallas is coming off an epic disaster at home, but it only counts as one loss. Many love to overact, but it was a comical display for the Cowboy haters to see them struggle so mightily in defeat against Denver.

Had the Cowboys won, they would have become the temporary top seed in the NFC.

Everybody is losing these days, but the ability to bounce back and win at home will be vital. Dak Prescott (calf) underperformed in his first game, and he will need to do a better job of moving the chains.

Amari Cooper and CeeDee Lamb were inept throughout the game, and Ezekiel Elliott (knee) wasn’t running with the same energy he often has. Leaving the game and coming back is a challenge for an NFL player.

The Falcon defense has been improving, but Dallas should put forth a much better performance after their Week 9 clunker.

Buffalo Bills vs. New York Jets

  • Bills (-13) -110
  • Jets (+13) -110
  • Over 47.5 -110
  • Under 47.5 -110

The Bills are coming off a challenging and humbling loss. The Jets were thumped by the Colts, despite nearly pulling off a backdoor cover.

Buffalo has done well as double-digit road favorites. They have covered and won four of their past six.

That includes gagging against the Jaguars and missing the bus on offense. The Bills are 3-4 as road favorites regardless of the spread.

The Jets have covered in four of their past five home games as an underdog. Mike White (forearm) should return to the starting lineup despite exiting early in their Thursday Night Football defeat.

Corey Davis (hip) may also return, so we could see an AFC East clash that comes down to the wire.

New Orleans Saints vs. Tennessee Titans

  • Saints (+2.5) -105
  • Titans (-2.5) -115
  • Over 44.5 (-110)
  • Under 44.5 (-110)

This non-conference matchup would have been better with Michael Thomas and Derrick Henry, but both teams are missing some of the stars that have carried them. Henry is certainly above Thomas, but they have made an impact these past four seasons.

Trevor Siemian and Taysom Hill are under center for New Orleans, and they are a capable duo that will keep the Saints in their matchup in Tennessee.

The Saints have quietly been an exceptional road underdog. New Orleans has covered in five straight as a road underdog while winning all five outright.

The winning goes back to 2019, but their defense and Alvin Kamara have made the difference. Kamara is on pace to have another stellar season, and he is the model of consistency.

Marshall Faulk, Roger Craig, and LaDainian Tomlinson are three of the better pass-catching backs in the past half-century. Kamara should continue to go off in the passing game.

  • 2017: 81 receptions
  • 2018: 81 receptions
  • 2019: 81 receptions
  • 2020: 83 receptions

Ryan Tannehill is an athletic runner that played wide receiver at Texas A&M, but he has been a Top 10-like signal-caller for the past few seasons. Yes, Henry has taken off loads of pressure, but the weapons around him can expose most defensive backs.

Taking care of the ball and moving the chains will be a challenge against better defenses like the Saints, but their home cooking has been helpful.

Tampa Bay Buccaneers vs. Washington Football Team

  • Buccaneers (-7.5) -120
  • Washington (+7.5) +100
  • Over 51 (-110)
  • Under 51 (-110)

Tom Brady’s most challenging postseason game last year was at Washington. Going against Taylor Heinicke was not a walk in the park, thanks to his ability to extend plays outside the pocket.

Wide receiver Terry McLaurin has been either getting limited by opposing defenses or feasting on them. Tampa Bay has struggled against the pass this season, and they could give up their fair share of yards in this one.

Luckily, TB12 and their offensive pieces will be well-rested, and the whole gang should be back. Rob Gronkowski and Antonio Brown are two reliable options when healthy for Brady. Look for them to get back to being featured.

Tampa Bay has failed to cover spreads as a road favorite, going 3-7 ATS in their past ten games. They have won seven of their past nine outright, but only two of those games had spread over a touchdown.

Washington, as a home underdog of at least a touchdown, has struggled. They are 1-9 as home dogs of a touchdown-plus, but they are a respectable 4-4-2 against the spread.

Detroit Lions vs. Pittsburgh Steelers

  • Lions (+9) -110
  • Steelers (-9) -110
  • Over 43.5 (-110)
  • Under 43.5 (-110)

The Lions are coming off a bye week, but they are running into an upward trending Steelers squad with playoff aspirations.

One of the top reasons for the offensive surge by Pittsburgh has been their top offensive playmakers. Ben Roethlisberger has taken care of the ball, but they are staying ahead of the chains.

Diontae Johnson has been an automatic first down and a difference-maker in the open field. Ben has peppered him with targets thus far, and the Bears have struggled in the secondary.

Najee Harris has been one of the better backs in the league, and he could wreak havoc on the Lions.

Detroit has lost six straight as road underdogs of more than a touchdown, but they have now lost 28 of their last 29 road games with that spread.

Minnesota Vikings vs. Los Angeles Chargers

  • Vikings (+3) -115
  • Chargers (-3) -105
  • Over 50.5 (-110)
  • Under 50.5 (-110)

The Vikings are an inconsistent squad that has been a challenge to trust. The Chargers are right there, so expect the unexpected in this pivotal non-conference clash that brings playoff aspirations.

Kirk Cousins has been a better passer on the road due to vanilla play-calling at home by Mike Zimmer. Dalvin Cook needs to be featured more in the passing game and connecting with Justin Jefferson should be imperative.

Adam Thielen has continued his red-zone production, but the defensive backs have been baffled by opposing wide receivers. Keenan Allen and Mike Williams are a pair of wideouts that could have their way against one of the lesser talented back sevens in the league.

Justin Herbert struggled to take care of the ball against the Patriots at home. However, the talent around his disposal is more than capable enough to matriculate the ball against Minnesota.

He has a hand cannon and could have one of his better games of the season against Minnesota.

The Vikings have covered in four of their past six as the road underdog (pre-Ravens). Los Angeles has won six of their past nine games as home favorites, but they are only 5-4 against the spread.

The under has hit on in five of the past seven games. Both teams have been prone to relying on the ground game in crucial spots this season.

Carolina Panthers vs. Arizona Cardinals

  • Panthers (+10) -110
  • Cardinals (-10) -110
  • Over 45.5 (-110)
  • Under 45.5 (-110)

The Panthers hung in there for a half against the Patriots, but then the turnover bug struck. Having Christian McCaffrey returns for over half the workload. He was a boost to their offense, even if it didn’t show up on the scoreboard.

Carolina has covered in seven of their past eight games as a road underdog. They have even won three of them outright, most recently stunning the Falcons. The Panthers need more from Darnold, who has been disastrous for most of the season since starting 3-0.

Arizona won on the road at San Francisco without two of their best players. Kyler Murray (ankle) and DeAndre Hopkins (hamstring) will be questionable all week, so stay updated on their status. If either one is out, value screams with Carolina.

The Panthers are a young team. They have had more roller coasters than many teams will see in an entire season. The Cardinals have a bevy of defensive playmakers that have had parties in the backfield.

Their speed and ability to run the ball downhill with James Conner have been impressive. He is coming off a near 200-yard performance with three touchdowns.

If he can continue to dominate, the Cardinals will continue to win games to maintain their lead in the NFC West.

Seattle Seahawks vs. Green Bay Packers

  • Seahawks (+6) -110
  • Packers (-6) -110
  • Over 49.5 (-110)
  • Under 49.5 (-110)

SEA-GB is one of those games you will want to wager on until potentially gametime. Aaron Rodgers may play, but we may not know until Saturday. The health of Russell Wilson (finger) is up for grabs as well.

The Packers and Seahawks have two premier passers with their starters, but the backups have been less than stellar. Geno Smith has been a solid game-manager, but he has gone through struggles as a pocket passer.

Until we know the status of the superstars under center, this is one to wait to see where the numbers fall on with additional information.

Philadelphia Eagles vs. Denver Broncos

  • Eagles (+2.5) -103
  • Broncos (-2.5) -117
  • Over 45 (-105)
  • Under 45 (-115)

Jalen Hurts, and his playing time is ticking for the Eagles. The struggles in the passing game have been apparent from early in the season.

We saw the disappointing performance against Dallas on Monday Night Football earlier in the season, but the lack of a proven commodity on the offense has derailed his progress.

The coaching staff is inexperienced, making this a challenging spot against a Denver defense that can harass opposing signal-callers. The Bronco offense has failed to be consistent, which is why this total is low.

Look a few weeks back to the Washington-Denver matchup, and this one could be similar. Drives will stall in the red zone, and points will be at a premium.

The Eagles are 2-6 in their past eight games as the road underdog. The Broncos have won five of their past seven home games straight up as a favorite but are a mediocre 4-3 ATS.

Kansas City Chiefs vs. Las Vegas Raiders

  • Chiefs (+3) -105
  • Raiders (-3) -115
  • Over 53.5 (-110)
  • Under 53.5 (-110)

The Chiefs have won six of the last seven contests against the Raiders. Three of those came down to the wire within a single score, but Kansas City has been able to excel against the AFC West.

Since 2018, Kansas City has gone 15-4 straight up in divisional games. The Chiefs have not been the top offensive club we are accustomed to seeing. However, we will see their offense hang close to 40 points eventually.

Their defense has played above their expectations, but it was below the middle of the pack entering Week 9. The KC offense is going to explode sooner than later.

Tyreek Hill looks healthy out there and has been able to have another solid season with Mahomes, who looks to be taking care of the ball a bit better than earlier in the season.

Plus, Hill was not fully healthy a few weeks ago, and there are plenty of more video game-like performances ahead in the sixth season of his career.

Kansas City has kept the opposition in the game due to their lack of defense, making this 53.5 total tempting. KC-VEGAS marks the seventh straight game between these two with a point total of 50-plus points.

The team to have the ball last in this one could find a way to pull off the victory.

Los Angeles Rams vs. San Francisco 49ers

  • Rams (-3) -120
  • 49ers (+3) +100
  • Over 47.5 (-115)
  • Under 47.5 (-105)

These two NFC West rivals have been playing since 1966, and the 49ers hold a 59-50-2 record entering this MND matchup.

The NFC West can claim the top division in football, but San Francisco will need to make the most of their opportunities against the top favorites in the conference.

The team has slowly gotten healthier in November, but the Rams have been mediocre against the spread as road favorites.

The public is often hammering them, which should cause concern. Check to see where the gen pub is leaning but realize we can throw the record books out when these two clash.

Cooper Kupp is looking very Jerry Rice-like season where he is posting gaudy numbers on the season. He is poised to break some franchise records if he keeps his torrid pace going.

  • Single-Season Receiving Touchdowns
  • Single-Season Receptions: Isaac Bruce (119, 1995)
  • Single-Season Receiving Yards: Isaac Bruce (1,781, 1995)

Matthew Stafford has been able to force-feed the ball to Kupp, but Robert Woods is still a reliable second option. These two offenses have played some of their better ball in recent weeks, so we could see the points flowing.

Betting on the NFL in Week 10

These games will frequently change throughout the week as injuries develop and have more clarity on them.

The value will be available to jump on for a few games, but others are worth the wait. Most players practice fully on Wednesday or Thursday, so be on the look to see if stars are missing in action.

Lastly, be sure to check out our NFL picks page, where you can see all the previews and predictions for the upcoming week.

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