Looking Ahead to Week 2 Odds of the College Football Season

By Dan Vasta in College Football
| September 8, 2021 11:07 am PDT

The 2021 college football season openers were off the charts. There were dazzling displays of athleticism, and many of the games had competitive spreads.

There are two matchups involving Top 25 teams, and they involve two Big Ten squads.

The pivotal non-conference matchups between Iowa-Iowa State and Oregon-Ohio State could be barn-burners.

With another wild week of college football ahead of us, let’s look at the early week two college football betting lines, and quickly breakdown each Top 25 matchup.

College Football Betting Lines for Week 2

  • Kansas (+25.5) -110 at No. 17 Coastal Carolina (-25.5) – 110
  • 12 Oregon (+14) -105 at No. 3 Ohio State (-14) -115
  • 13 Florida (-28) -110 at South Florida (+28) -110
  • Toledo (+16.5) -105 at No. 8 Notre Dame (-16.5) -115
  • UAB (+25) -110 at No. 2 Georgia (-25) -110
  • 5 Texas A&M (-17) -115 at Colorado (+17) -105
  • Ball State (+22.5) -110 at No. 11 Penn State (-22.5) -110
  • 10 Iowa (+3.5) +105 at No. 9 Iowa State (-3.5) -125
  • Eastern Michigan (+25.5) -105 at No. 18 Wisconsin (-25.5) -115
  • Appalachian State (+8) -108 at No. 22 Miami (-8) -112
  • 15 Texas (+6.5) -120 at Arkansas (+6.5) +100
  • Georgia State (+25) -105 at No. 24 North Carolina (-25) -115
  • 21 Utah (-7) -113 at BYU (+7) -107
  • Stanford (+17) -110 at No. 14 USC (-17) -110
  • UNLV (+32.5) -110 at No. 23 Arizona State (-32.5) -110
  • Middle Tennessee State (+19.5) -115 at No. 19 Virginia Tech (-19.5) -105

The second weekend full of games will have adjustments made from a few underwhelming performances. We saw Texas listed as a slightly heavier favorite after dominating Louisiana in their opener.

Michigan is also moving up the charts after handling Western Michigan with such ease. Plus, Washington became the fifth-ranked FBS team since 1978 to lose to an FCS squad.

The college football week two betting odds above can be found at BetOnline, but it’s smart to shop around.

Before you decide which game you want to bet on, join me as I take a quick look at every game featuring a Top 25 squad this week.

Kansas at No. 17 Coastal Carolina

  • Kansas (+25.5) -112
  • Coastal Carolina (-25.5) -108
  • Kansas to Win (+1500)
  • Coastal Carolina to Win (-4000)
  • Over 52 (-110)
  • Under 52 (-110)

The top college football betting sites have Coastal Carolina as a huge favorite in week two.

Kansas has lost and failed to cover in their last seven games against the AP Top 25. They were 0-4 last season but will need a miracle to pull this outright upset.

Coastal Carolina has been a cover machine the past two years, going 17-9. They were ironically a six-point underdog at Kansas last season and won 38-23.

The Jayhawks only need one more win to hit the over on their win mark total (1.5), but this isn’t the one they likely will pull off.

No. 12 Oregon at No. 3 Ohio State

  • Oregon (+14.5) -110
  • Ohio State (-14.5) -110
  • Oregon to Win (+500)
  • Ohio State to Win (-650)
  • Over 63.5 (-110)
  • Under 63.5 (-110)

The Buckeyes have quietly gone 7-4 in their last 11 regular-season games against the AP Top 25. Ryan Day is 11-2 at Ohio State against ranked foes.

Mario Cristobal is 6-5 at Oregon against ranked foes but has covered in six of the last ten matchups. Kayvon Thibodeaux (ankle) could be out, which certainly would be costly against the Buckeyes.

Another nugget to note is Ohio State is 3-2 against the spread in their last five September home games in which they are favored by two touchdowns or less.

No. 13 Florida at South Florida

  • Florida (-28) -110
  • South Florida (+28) -110
  • Florida to Win (-5000)
  • South Florida to Win (+1500)
  • Over 58 (-110)
  • Under 58 (-110)

The Gators have not been this large of a road favorite in September since 2001 against Kentucky (-30). Florida under Dan Mullen is 6-4, including a 1-3 record last season.

The Bulls lost to NC State in their opener, and the game was lopsided. They have lost eight straight games against ranked foes dating back to 2016 when they upset No. 22 Navy, 52-45.

This is one of several spots with pretty wild spreads. They can be tough to figure out, so do yourself a favor and check out this breakdown of how to deal with big point spreads in college football.

Toledo at No. 8 Notre Dame

  • Toledo (+16.5) -105
  • Notre Dame (-16.5) -115
  • Toledo to Win (+665)
  • Notre Dame to Win (-925)
  • Over 55 (-110)
  • Under 55 (-110)

After a wacky victory in overtime against Florida State, we saw Notre Dame fail to cover as touchdown-plus favorites.

It got vintage Brian Kelly anger rolling, too, to the point where he jokingly called for his team’s execution.

“I’m in favor of execution. Maybe our entire team needs to be executed after tonight.”


While that was regrettable, Notre Dame still won, and they waltz into week two as huge favorites over Toledo.

The Irish are 27-30-3 under Kelly at home against the spread, but they went 1-4 last year.

Toledo has never played Notre Dame, but the Rockets are 0-5 against the spread against the Power Five and are 1-4 straight up. Their last victory came against Iowa State in 2015, before Matt Campbell took over and dominated.

UAB at No. 2 Georgia

  • UAB (+26.5) -108
  • Georgia (-26.5) -112
  • UAB to Win (+1500)
  • Georgia to Win (-4000)
  • Over 43.5 (-110)
  • Under 43.5 (-110)

The Bulldogs are coming off their best victory seemingly in forever. They thoroughly dominated Clemson, and look like legit title threats.

They have failed to cover in four of the last six home games as 26-plus point favorites. Those games were all in September. Georgia has won nine straight home openers, and UAB will struggle, even if they win C-USA.

Kirby Smart praised the Blazers immediately after the Clemson game. Still, UAB is 2-27 all-time against the SEC. They are 0-4 straight up and overall against Power Five teams in their program renewal.

No. 5 Texas A&M at Colorado

  • Texas A&M (-17) -115
  • Colorado (+17) -105
  • Texas A&M to Win (-900)
  • Colorado to Win (+640)
  • Over 50.5 (-110)
  • Under 50.5 (-110)

Jimbo Fisher is an impressive 5-0 in neutral-site games at Texas A&M. Colorado and Texas A&M were Big 12 rivals for 15 years, but the Buffaloes won the last matchup in 2009.

Texas A&M is 7-9 in their past 16 games as a 16-plus point favorite. A dozen of those games were against non-conference foes.

Colorado is 5-2 in their last seven, in which they are underdogs of 16-plus points. If you are considering the money line, maybe try another game. Colorado has lost 25 straight games with a spread of 16 or more as an underdog.

Ball State at No. 11 Penn State

  • Ball State (+22.5) -110
  • Penn State (-22.5) -110
  • Ball State to Win (+750)
  • Penn State to Win (-2000)
  • Over 57.5 (-110)
  • Under 57.5 (-110)

Penn State is 34-2 all-time against the MAC, and they are three-plus touchdown favorites in their home opener.

The Nittany Lions are 3-6-1 in their last ten home games as favorites. Penn State is 3-6 in their past nine home games, as 22-plus point favorites.

Penn State is fresh off a surprise win over the Wisconsin Badgers, and they’ll look to keep building up their 2021 resume here.

No. 10 Iowa at No. 9 Iowa State

  • Iowa (+3.5) +105
  • Iowa State (-3.5) -125
  • Iowa to Win (+165)
  • Iowa State to Win (-190)
  • Over 45.5 (-110)
  • Under 45.5 (-110)

Excluding last season, this series has been played every year since 1977. The Cyclones have lost the past five Cy-Hawk rivalry games while covering just once.

Iowa is 5-4-1 in their last ten against Iowa State, but this game is epic. It features a potent Cyclones offense led by Brock Purdy and Breece Hall.

The Hawkeyes haven’t been an underdog in this rivalry since 2000.

The Cyclones have lost six of the past seven meetings. Iowa and Iowa State will also be playing in the first-ever game, in which both squads are in the Top 25.

Eastern Michigan at No. 18 Wisconsin

  • Eastern Michigan (+25.5) -108
  • Wisconsin (-25.5) -112
  • Eastern Michigan to Win (+1500)
  • Wisconsin to Win (-4000)
  • Over 52 (-110)
  • Under 52 (-110)

The Badgers could run the score up a bit in this non-conference meeting, especially after dropping the ball last week.

Wisconsin has gone 5-5 against the spread as 24-plus point favorites.

Wisconsin is 34-1 against the MAC all-time, with their lone loss coming to Western Michigan in 1988.

My condolences, Eastern Michigan.

In all seriousness, Wisconsin should go ham here. If they don’t, their already severely dwindled title chances could evaporate completely.

Appalachian State at No. 22 Miami

  • Appalachian State (+8) -108
  • Miami (-8) -112
  • Appalachian State to Win (+260)
  • Miami to Win (-310)
  • Over 53.5 (-115)
  • Under 53.5 (-105)

Miami is licking their wounds after their disappointing beatdown to Alabama. They have gone 4-0 against the Sun Belt with an average margin of victory at 23.75 points per game.

Appalachian State is no lowly squad, and they could run the table this season and be a featured team to play in the New Year’s Six.

The Mountaineers are only 8-27-1 against the ACC, but they did win their last game against North Carolina in 2019.

No. 15 Texas at Arkansas

  • Texas (-6.5) -120
  • Arkansas (+6.5) +100
  • Texas to Win (-250)
  • Arkansas to Win (+210)
  • Over 57 (-110)
  • Under 57 (-110)

Texas vs. Arkansas will be electric. The matchup could be one of the better atmospheres of the weekend as an old Southwestern Conference rivalry gets reacquainted.

The Razorbacks are 22-56 all-time against Texas. Still, they have won four of the last six, which goes back to 1991. They played in the 2000 Cotton Bowl and then the 2014 Texas Bowl.

Arkansas is 0-5 straight up and 1-4 in September home games in which they are under a touchdown underdog. Since 2010, Texas is 4-0 against the spread and straight-up as a favorite of six points or fewer.

The Longhorns unleashed a star last week with Bijan Robinson popping off in a win.

It will be interesting to see if he can keep it rolling here. Texas isn’t a big favorite, but they still appear to be a good bet to get the job done in week two.

Georgia State at No. 24 North Carolina

  • Georgia State (+25) -105
  • North Carolina (-25) -115
  • Georgia State to Win (+1500)
  • North Carolina to Win (-4000)
  • Over 65.5 (-115)
  • Under 65.5 (-105)

North Carolina had a disastrous offensive performance in their opener at Virginia Tech. So, they could take out their frustrations on this Sun Belt foe.

Mack Brown is 77-68-1 at home against the spread, and that goes back to his days with the Heels in his first tenure. UNC is a magical 9-1 straight up and 8-2 against the spread in their home openers.

No. 21 Utah at BYU

  • Utah (+7) -113
  • BYU (-7) -107
  • Utah to Win (-275)
  • BYU to Win (+230)
  • Over 48 (-108)
  • Under 48 (-112)

Kyle Whittingham and the Utes have dominated the Holy War. Utah has gone 9-1 outright with a 7-3 record against the spread in the past ten matchups.

BYU has averaged a lowly 18.1 points per game in the past ten games, but Utah has lofty expectations.

Whittingham and the Utes could put together a similar season to what BYU had last year with Zach Wilson. The Cougars are looking for their first win since 2009.

Stanford at No. 14 USC

  • Stanford (+17) -110
  • USC (-17) -110
  • Stanford to Win (+660)
  • USC to Win (-1000)
  • Over 52 (-110)
  • Under 52 (-110)

The track record for these two has been premier matchups, but the results have not gone well for David Shaw. Stanford barely avoided a shutout to Kansas State, who is not known for their stellar 1985 Bears-like defense.

USC has won three of the four most recent matchups, and only two of the four were close.

USC won by 43 points in the other two and Stanford is now in rare territory.

The last time they were more than an 18-point underdog was in 2008, with Oregon laying 24 points. The game before that was Stanford in 2007. That was where the Cardinal won outright as a 41-point underdog in some sportsbooks to USC.

Middle Tennessee State at No. 19 Virginia Tech

  • Middle Tennessee State (+19.5) -115
  • Virginia Tech (-19.5) -105
  • Middle Tennessee State to Win (+750)
  • Virginia Tech to Win (-1200)
  • Over 52 (-110)
  • Under 52 (-110)

The Hokies are 14-11 under Justin Fuente as a home favorite. Coming off their thrilling victory over North Carolina, Virginia Tech rides the momentum train against C-USA.

Virginia Tech had won 11 straight home games against Non-Power Five foes before Liberty stunned them in Blacksburg last season as 16-point underdogs.

This will be the first meeting between the two and the Blue Raiders have lost seven straight games against the Power Five while going 2-5 against the spread.

UNLV at No. 23 Arizona State

  • UNLV (+32.5) -110
  • Arizona State (-32.5) -110
  • Over 55.5 (-110)
  • Under 55.5 (-110)

This may not normally be a game that stands out, but it does when looking at the early week two college football betting lines. It’s set at 32.5 at most sportsbooks, which is absolutely staggering.

The final game of the weekend involving a Top 25 team will be the Sun Devils and the Rebels.

UNLV is coming off a loss to an FCS squad, but Arizona State has not been accustomed to laying this much at home.

Going back to 2008, the Sun Devils are 1-6 against the spread when favored by 33-plus points despite a 7-0 record straight up.

Week 2 College Football Betting Advice

Another weekend slate of Top 25 games is upon us. These early week two college football betting lines don’t necessarily tell you how to bet, but you have to start somewhere.

The Big Ten will be in the spotlight after the SEC and ACC dominated most of it last weekend. Keep in mind these numbers are from early in the week. They will adjust quite frequently throughout the week up until kickoff.

As the weekend draws closer and you’re ready to finalize your wagers, be sure to stop by our college football betting picks page.



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