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Early NFL Betting Odds Breakdown for Week 6 in the NFL

| October 11, 2021 6:25 am PDT

Bettors love few things more than looking ahead. Week five of the 2021 NFL season isn’t even officially over as I sit down to write this.

Lamar Jackson and his Baltimore Ravens still haven’t played on Monday Night Football, and yet I am looking to week six.

It feels silly at times, given the fact that odds for every game aren’t out, the lines change, and injuries can shake things up over the next week. But that early look at the NFL betting lines can also be extremely useful.

At worst, it gives you a look at the odds and allows you to assess the slate of games. At best, you may see an advantageous bet too good to pass up.

Let’s see if we can’t run into a little bit of both this week. Here’s a breakdown of the week six NFL betting lines.

Early Week 6 NFL Odds

  • Buccaneers (-7) -102 vs. Eagles (+7) -118
  • Dolphins (-3) -110 vs. Jaguars (+3) -110
  • Texans (+10) -115 vs. Colts (-10) -105
  • Packers (-4.5) -110 vs. Bears (+4.5) -110
  • Vikings (PK) -105 vs. Panthers (PK) -115
  • Chargers (+3.5) -115 vs. Ravens (-3.5) -105
  • Bengals (-3.5) -110 vs. Lions (+3.5) -110
  • Rams (-10.5) -110 vs. Giants (+10.5) -110
  • Cardinals (+2.5) -103 vs. Browns (-2.5) -117
  • Raiders (+3) +100 vs. Broncos (-3) -120
  • Cowboys (-3.5) -115 vs. Patriots (+3.5) -105
  • Seahawks (+4) -110 vs. Steelers (-4) -110

The early week six NFL betting lines above are courtesy of BetOnline. There are some nice spots to consider right away, but two in particular are staring back at me.

When I talk about hopping on early NFL odds, the first point spreads that come to mind are the Rams (-10.5) and Steelers (-4).

Injuries are going to reshape how we bet on these games, and some line movement could be on its way.

New York saw three key offensive players exit Sunday’s game due to injury, while Seattle must endure life in the NFL for up to two months sans Russell Wilson.

Those lines look suspect, but they could be thicker, and nobody would bat an eye. There is even more that stands out when glancing at the week six NFL betting lines.

Let’s dig deeper as we peek at every matchup with odds so far.

Buccaneers vs. Eagles

  • Buccaneers (-7) -102
  • Eagles (+7) -118
  • Buccaneers to Win (-290)
  • Eagles to Win (+245)
  • Over 53 (-110)
  • Under 53 (-110)

Tom Brady and his Bucs head to the City of Brotherly Love in week six, and it’ll be on a short week as they clash on Thursday Night Football.

I’m not a believer in the Eagles at all, but let’s not ignore that this isn’t an easy place to play, and the short week can be tough on even the best of teams.

That, and Jalen Hurts and co. showed heart as they rallied to take out a seemingly solid Panthers team in week five.

Brady tossed five touchdowns in a total demolition of the Dolphins, of course.

Tampa Bay remains uber-stacked, and I’m still a bit shocked they have a loss on their ledger. I suspect they’ll keep humming along here, but the 7-point spread does feel a bit hefty.

I still think it’s doable, but given the immense offensive upside here, the 53-game total feels like the bet to target.

Don’t just take my word for it, though. Learn all about football point spreads to know when to pounce on them.

Dolphins vs. Jaguars

  • Dolphins (-3) -110
  • Jaguars (+3) -110
  • Over 45 (-110)
  • Under 45 (-110)

The Urban Meyer saga has at least temporarily been swept under the rug. It’s unclear if it trickled onto the field, but it sure is alarming that the guy can’t even take ownership over his personnel being deployed.

Regardless, Jacksonville remains winless, and there is literally a bet out there that asks if Meyer will finish the season with the Jags. At this point, I’m not sure he will.

The good news? Jacksonville is at home, and this could be their best chance yet to get a win.

The Jaguars should have a win by now, but they can always stop the bleeding against a hapless Miami team that has had a rough 2021 this far.

This game is appropriately priced tightly, and as I write this, you can only bet on the spread or game total.

Nothing really stands out here, but home dogs are always interesting. Jacksonville should back into a win at some point, and this could be the spot for bettors to back them, whether it be straight up or against the spread.

Texans vs. Colts

  • Texans (+10) -115
  • Colts (-10) -105
  • Over 42.5 (-110)
  • Under 42.5 (-110)

The top NFL betting sites don’t yet have a moneyline for this one, either, but Indy will obviously be huge favorites at home against a Texans team that has just one win.

Houston has shown some fight at times, though, while Davis Mils uncorked an unbelievable performance against the mighty Bill Belichikc-led Pats last week.

It still ended in a loss, but are the best online sportsbooks shortchanging Houston here? Eh, probably not.

I’m writing this before the Colts inevitably lose to the Ravens on MNF, so they’ll look to lick their wounds with a big bounce-back game here. That said, this feels like a game to stay away from, across the board.

Packers vs. Bears

  • Packers (-4.5) -110
  • Bears (+4.5) -110
  • Packers to Win (-215)
  • Bears to Win (+185)
  • Over 46 (-110)
  • Under 46 (-110)

Green Bay survived it’s second nail-biter in the last three weeks, and they’re now a remarkable 4-1 despite being hit hard by injuries.

Here’s a quick look at the key players they’ve been missing.

  • Top 2 Offensive Linemen
  • Top Edge Rusher
  • Top Cornerback
  • Top Deep Threat

The Packers haven’t made excuses, though. They went into Cincinnati and outlasted the Bengals in overtime, and now they head to Soldier Field for a game that will temporarily decide first place in the NFC North.

For a team that still has Super Bowl hopes, Green Bay has to know what is on the line here. Of course, the Bears are 3-2 after a rocky start, and seem to be slowly easing rookie quarterback Justin Fields into a starring role.

Chicago’s defense gives them a real shot at the upset at home, so the Bears at +4.5 looks like the play in this spot. More than anything, though, this feels like a classic, tense affair between rivals, making this 46-game total come off as a bit bloated.

Vikings vs. Panthers

  • Vikings (PK) -105
  • Panthers (PK) -115
  • Over 47 (-110)
  • Under 47 (-110)

Minnesota keeps finding a way to stay relevant. They took out the Lions this past week on a last-second field goal, and if the Bears help them next week, they could remain in the race for the NFC North.

It’s debatable how good their chances are to get a win themselves, however, as they have to travel to Carolina to battle a solid Panthers team.

Sam Darnold imploded in a sea of turnovers in a tough loss last week, as the previously 3-0 Panthers dropped to 3-2. Luckily, they could be getting Christian McCaffrey back for this contest.

C-Mac’s return would likely put the Panthers in the driver’s seat here, as they’re at home and probably the more cohesive team. It’d nudge this game closer to being a high-scoring affair, which would put the onus on the Over, as well.

Before the news of McCaffrey’s return becomes official, bettors may want to consider hammering the Panthers at this -115 price.

Chargers vs. Ravens

  • Chargers (+3.5) -115
  • Ravens (-3.5) -105
  • Over 50 (-110)
  • Under 50 (-110)

I don’t know yet what to think of Baltimore going into week six, as I’m writing this before they play on Monday Night Football. Provided Lamar Jackson doesn’t get hurt, though, they could live up to the hype as mild home favorites.

The Ravens have been “meh” against the spread to this point, but they were among the league’s best (11-7) in 2020, and they were 5-3 ATS as home favorites.

I respect those numbers, and I also won’t mock a sound Ravens team in a huge home game like this.

L.A. has to be tired, anyways. The Bolts are atop the AFC West at an impressive 4-1, and they just got done with a marathon meeting with the Browns.

Seriously, that was one epic shootout.

Those types of NFL classics are tough to follow-up. L.A. survived the Browns but doing that in consecutive weeks against yet another team that loves to run the football – and does it so well – is a lot to ask.

I’d give the Ravens a hard lean here, and given their run-first mentality, the 50 total comes off a bit high, as well. For what it’s worth, Ravens games have seen the Over go 2-2 in 2021, and 7-11 in 2020.

Bengals vs. Lions

  • Bengals (-3.5) -110
  • Lions (+3.5) -110
  • Over 48 (-110)
  • Under 48 (-110)

This line feels a bit disrespectful to the Bengals, who so far have only lost to a 4-1 Packers squad and the Bears on the road.

Most of their games have been close, though, so with that in mind, you can forgive the bookies. After all, just one of Cincinnati’s five games in 2021 have been decided by more than a field goal.

Cincy could also be reeling from an overtime loss at home, and it’s unknown what the status of franchise passer Joe Burrow will be due to an alleged throat poke.

Burrow is likely still going to suit up here, and the Bengals are the better team with a lot on the line. Detroit is inching dangerously close to that elusive first win, but I’m not sure I’d bet on it coming in week six.

All things considered, Cincy at -3.5 looks like a steal.

Rams vs. Giants

  • Rams (-10.5) -110
  • Giants (+10.5) -110
  • Over 47.5 (-110)
  • Under 47.5 (-110)

I touched on this game due to the many injuries for Big Blue right now. New York was hanging around in an intense NFC East battle with the Cowboys, but a litany of injuries derailed them.

Here are the key players in doubt for their week six tilt with the Rams.

  • QB Daniel Jones (concussion)
  • RB Saquon Barkley (ankle sprain)
  • WR Kenny Golladay (knee)

These are rather large absences, and they contributed to a blowout loss to a rival.

New York actually has a shot at bouncing back at home if they’re healthy. Their offense is that talented. However, they’d already been trying to get by with the likes of Darius Slayton and Sterling Shepard on the sidelines, so this is just the icing on the cake for them.

I’m probably giving the Giants a bit too much credit, too. This is still the Rams, who have lost to the undefeated Cardinals, and mostly murdered just about everyone else they’ve run into.

When you look at everything, you just can’t hammer the Rams’ -10.5 spread quickly enough. While true, the total feels light here. New York has offensive ability, and the Over is 4-1 in Rams games in 2021.

Cardinals (+2.5) -103 vs. Browns (-2.5) -117

  • Cardinals (+2.5) -103
  • Browns (-2.5) -117
  • Cardinals to Win (+140)
  • Browns to Win (-160)
  • Over 54.5 (-110)
  • Under 54.5 (-110)

I’ll be honest, it really bothers me that the Browns are already favored here. I was hoping Arizona being undefeated would get Cleveland in at plus money.

Bettors can only work with what’s given to them, though, and I see this as a redemption spot for the Browns.

Cleveland poured their heart and soul into a crazy loss in Los Angeles, but fundamentally, this is a matchup they can thrive in.

Cleveland has the pass rushers to give Kyler Murray issues on the outside, while their running game is a perfect counter to everything the Cardinals do.

Not only is Arizona’s pass defense their main strength defensively, but eating clock and keeping the ball out of Murray’s hands has to be part of the Browns’ game plan.

Arizona can’t win forever, they’re on the road, and the Browns should be equipped to hand them their first L. I wish it came with a better price, but the Browns’ ML or point spread should still be plenty inviting here.

Raiders (+3) +100 vs. Broncos (-3) -120

  • Raiders (+3) +100
  • Broncos (-3) -120
  • Over 44.5 (-110)
  • Under 44.5 (-110)

We’re going to find out quickly who is a pretender in the AFC West. Both the Broncos and Raiders got off to surprise 3-0 starts, but one of them will exit week six at 3-3.

That’s not a good place to be in this loaded division, so I anticipate a slugfest here. The points won’t be coming easily, so I tip my cap to the ugly 44.5 total.

There’s also the ongoing Jon Gruden email saga.

Las Vegas didn’t perform very well in the wake of that news, and this feels like a difficult spot to trust the Raiders.

It’s likely just a game to avoid in general, but Denver at home against a rival could be a team worth backing.

Cowboys vs. Patriots

  • Cowboys (-3.5) -115
  • Patriots (+3.5) -105
  • Cowboys to Win (-190)
  • Patriots to Win (+165)
  • Over 48.5 (-110)
  • Under 48.5 (-110)

I have never doubted the talent the Cowboys have on their roster. Dak Prescott’s amazing comeback from last year’s devastating injury even makes this team fun to root for.

Throw in a supposedly improved defense, and Big D may really be onto something here.

Of course, the Cowboys’ main feather in the cap is a tight week one loss to the Bucs. Otherwise, we’re getting excited about them housing the Eagles and Giants, and narrowly beating a Christian McCaffrey-less Panthers team at home.

I think a trip to Foxboro against Bill Belichick will reveal just how good this offense is – and if Mike McCarthy can elevate this team from the sidelines.

Dallas will probably win, but this is absolutely a volatile setting if you’re planning on betting on them with even a shred of confidence.

Seahawks vs. Steelers

  • Seahawks (+4) -110
  • Steelers (-4) -110
  • Seahawks to Win (+175)
  • Steelers to Win (-205)
  • Over 43 (-105)
  • Under 43 (-115)

The last game with early week six NFL betting lines is this clash in Pittsburgh between the Seahawks and Steelers.

Big Ben and co. were left for dead after their 1-3 start, but they bounced back with a win over the Broncos. A win here, and suddenly they’re 3-3 and have life again.

I tend to think they can get the W, too, seeing as Seattle’s playoff hopes are now tied to the shaky hands of Geno Smith. This, thanks to a terrible injury to Russell Wilson.

Smith performed admirably following a Russell Wilson finger injury, but the shine may wear off in a tough road environment against a feisty Steelers defense.

Wilson’s return will likely be of the “too little, too late” variety in 6-8 weeks, and it’s quite possible his roster plays like it while he’s gone. I wouldn’t pay to go against that logic in week six.

Week 6 NFL Betting Advice

There is so much that goes into your NFL bets each week. Looking at the early NFL odds should always be a part of your process, as the top sportsbooks don’t always price things just right, or there is something not accounted for.

Of course, there is also often value in checking the early odds, and opting to wait.

How you bet on week six of the 2021 NFL season is up to you, but my biggest piece of advice is to simply chase the value.

What that is will depend on who you are as a bettor, but when you see a good bet, you usually know it. For week six, there are a few situations that pop off the page, and hopefully I’ve detailed them in my betting breakdown.

For more help with your week six NFL bets, check out our NFL betting picks section.

Noah Davis

Noah Davis is one of the more diverse writers at GamblingSites.com. Like many of his colleagues, he's a huge fan of both football and basketball. But he also writes about box office records, TV show prop bets, DFS, and all kinds of other subjects.

When it comes to the NFL, Noah's favorite team is the Cleveland Browns. He enjoys cheering them on with his wife and daughter.

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