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Betting Odds and Breakdown for Week 16 of the 2021 NFL Season

By Dan Vasta in NFL
| December 20, 2021 8:07 am PDT

We were fortunate to get a slate this past weekend with games being rescheduled for Monday and Tuesday. There were a few upsets and the top teams continued to find ways to come out victorious.

To analyze and dissect the upcoming Week 16 schedule, here are your top odds as we are down to the final three weeks of the season.

Early NFL Betting Odds for Week 16

  • 49ers (pk) -110 vs. Titans (pk) -110
  • Browns (+7) -110 vs. Packers (-7) -110
  • Colts (+3.5) -110 vs Cardinals (-3.5) -110
  • Buccaneers (-11.5) -110 vs Panthers (+11.5) -110
  • Giants (+8.5) -110 vs. Eagles (-8.5) -110
  • Chargers (-10.5) -110 vs. Texans (+10.5) -110
  • Lions (+6.5) -110 vs. Falcons (-6.5) -110
  • Ravens (+2.5) -110 vs. Bengals (-2.5) -110
  • Rams (-3.5) -110 vs Vikings (+3.5) -110
  • Jaguars (+1.5) -110 vs. Jets (-1.5) -110
  • Bills (+2) -110 vs. Patriots (-2) -110
  • Bears (+7) -110 vs. Seahawks (-7) -110
  • Steelers (+9.5) -110 vs. Chiefs (-9.5) -110
  • Broncos (-1) -110 vs. Raiders (+1) -110
  • Washington Football Team (+9.5) -110 vs. Cowboys (-9.5) -110
  • Dolphins (+3.5) -110 vs. Saints (-3.5) -110

For all your Week 16 updates, you can check them at SportsBetting.ag. The pricing is some of the best you will find among all the sportsbooks for the best value.

There will be vital injuries throughout the week such as Lamar Jackson that will dictate the upcoming odds and values.

This will also be the first week without scheduled byes since September. It is time to discuss the Week 16 slate with odds and analysis.

San Francisco 49ers vs. Tennessee Titans

  • 49ers (pk) -110
  • Titans (pk) -110
  • Over 44 (-110)
  • Under 44 (-110)

The 49ers and Titans are two smash-mouth football squads that love to play the game in a phone booth when possible. Mike Vrabel and Kyle Shanahan have done fine coaching jobs thus far, but this will come to quarterback play.

Coming off a two-turnover defeat to Pittsburgh, Ryan Tannehill will need to find playmakers in the passing attack. Julio Jones (hamstring) is likely missing this one and many fantasy folks have been fed up with his production.

The 49ers are looking great for a wild card berth, but another victory would practically lock it up. Tennessee was the top seed in the AFC prior to their recent loss, so they should try and bounce back to stay in the hunt.

Cleveland Browns vs. Green Bay Packers

  • Browns (+7) -110
  • Packers (-7) -110
  • Over 45 (-110)
  • Under 45 (-110)

I wrote this prior to the Cleveland matchup on Monday Night Football, but the Packers surely looked the part against the Ravens secondary.

While they snuck it out thanks to Baltimore going for a failed two-point conversion again, they have found ways to win all throughout the season. That could put them atop the NFC and into the lone bye week.

Jacksonville Jaguars vs. New York Jets

  • Jaguars (+1.5) -110
  • Jets (-1.5) -110
  • Over 43.5 (-110)
  • Under 43.5 (-110)

This is an ugly game that will be played like an early December bowl game between a pair of 6-7 squads. The Jets had a great start in the first half, but failed to score another offensive point against the Dolphins.

The fans are hopeful that Jacksonville can land the number one pick for the 2022 NFL Draft. The Jets aren’t far behind, but this is a game between two rookie signal-callers that could come down to the wire.

There is value on the Jets at home, an offense that has looked a bit better than the Jaguars.

These two have their eyes set on the upcoming 2022 NFL Draft.

Indianapolis Colts vs. Arizona Cardinals

  • Colts (+3.5) -110
  • Cardinals (-3.5) -110
  • Over 48.5 (-110)
  • Under 48.5 (-110)

This matchup’s number is all about home field advantage. The Colts have a case as the much stronger team currently.

These two teams are opposites in terms of momentum. The Colts are flexing their muscles on the defensive side of the ball thanks to their ability to control the line of scrimmage.

Jonathan Taylor set the Colts franchise record for most rushing TDs in a single season (17). He is one more game with a rushing score away from tying the NFL record owned by LaDainian Tomlinson.

Arizona is now on a losing streak after a disastrous loss to the Lions. They look safe to host a playoff game without DeAndre Hopkins, but they might not win a game in the postseason if they don’t turn it around quickly.

Tampa Bay Buccaneers vs. Carolina Panthers

  • Buccaneers (-11.5) -110
  • Panthers (+11.5) -110
  • Over 48.5 (-110)
  • Under 48.5 (-110)

The Panthers have been a disaster the past month. All the injuries have been adding up, but backup quarterback PJ Walker and backup receiver Brandon Zylstra were assigned to kicking duties after Zane Gonzalez was injured in pre-game warmups.

Even with recent struggles for the Bucs, they are in a much better place mentally and physically than Carolina. The Panthers were once in the playoff hunt in October, but the franchise has been falling on its face for a while. They lack the arsenal that Tampa has at its disposal.

New York Giants vs. Philadelphia Eagles

  • Giants (+8.5) -110
  • Eagles (-8.5) -110
  • Over 48.5 (-110)
  • Under 48.5 (-110)

The Giants’ issues at quarterback have been much maligned since Eli Manning has retired and Daniel Jones’ return isn’t going to fix their issues.

The inability to control the line of scrimmage or come away with enough turnovers has crushed their hopes this season in the NFC East.

The Eagles have a shortened week and surely one must view how their Tuesday matchups ends before considering laying a heavy number. Luckily, their health on the offensive side of the ball could play keep away in this divisional clash.

Detroit Lions vs. Atlanta Falcons

  • Lions (+6.5) -110
  • Falcons (-6.5) -110
  • Over 44.5 (-110)
  • Under 44.5 (-110)

This is an ugly one on paper, but both teams have been competitive in December. The Falcons have a glimmer of hope to reach the playoffs, and this is one they need to go and get.

Their inability to protect Matt Ryan has been a comedy act and they have not had a respectable run game since Michael Turner and Jerrious Norwood were in the backfield. Cordarrelle Patterson has been sensational for them, but they have been one-dimensional all year.

The Falcons are struggling at the line whereas the Lions are playing well in the trenches, which has allowed Jared Goff to have more time in the pocket.

Los Angeles Chargers vs. Houston Texans

  • Chargers (-10.5) -110
  • Texans (+10.5) -110
  • Over 47.5 (-110)
  • Under 47.5 (-110)

This current number tells you how far the Chargers have come. The Chargers have been playing well, but they blew their chances against the Chiefs last week. The overtime loss was a struggle as they had four failed attempts on fourth down.

That was 28 points they left off the board, but it should have been at least two or three field-goals teams don’t mess with. The Chargers have an opportunity to get back on the winning side with a Texans team that likely will not win another game.

To have updated information throughout the season, check out our NFL blog.

Baltimore Ravens vs. Cincinnati Bengals

  • Ravens (+2.5) -110
  • Bengals (-2.5) -110
  • Over 43.5 (-110)
  • Under 43.5 (-110)

This AFC North slugfest has playoff implications. There is a chance the division could get multiple teams in the playoffs.

The quarterback matchup is one to study throughout the week. Joe Burrow has been taking care of the football despite the recent lack of production by Ja’Marr Chase.

  • First Seven Games: 51 targets, 35 receptions, 754 yards and 6 TD
  • Last Seven Games: 51 targets, 26 receptions, 285 yards and 4 TD

However, there is a chance that this matchup ends up deciding the division with the loser staying home for the postseason. Lamar Jackson’s playing status is the one to watch all week.

Joe Mixon has been dinged up for parts of the season and his status could be iffy, so wager wisely with two of the most important players in this AFC North matchup.

Los Angeles Rams vs. Minnesota Vikings

  • Rams (-3.5) -110
  • Vikings (+3.5) -110
  • Over 43.5 (-110)
  • Under 43.5 (-110)

On paper, this could be the exciting matchup of the Christmas weekend. Kirk Cousins needs every game he can get these days. Justin Jefferson has been the most impressive wideout in the league these days alongside Cooper Kupp of the Rams.

Cousins loves having Dalvin Cook dominate the line of scrimmage to allow the passing attack to thrive. Jalen Ramsey and the Rams defense should be up for the challenge.

Matthew Stafford is playing at a high level as he attempts to win his first-career postseason game. The Rams have Super Bowl aspirations and have made it clear-cut with their play in recent weeks.

Suddenly, they have a shot at winning the division, but it should be a first-round matchup between the Cards and Rams regardless of who wins the division between the two.

Buffalo Bills vs. New England Patriots

  • Bills (+2) -110
  • Patriots (-2) -110
  • Over 43.5 (-110)
  • Under 43.5 (-110)

This game screams field positions and decisions on third downs. Josh Allen needs to be able to make throws on the run and get Stefon Diggs involved.

We saw the weather dictate the type of game we saw in the home defeat to New England. This number is all about leaning slightly with the home team.

The playoff seeding will adjust accordingly based on the results in this AFC East matchup. A victory for the Bills could give them the division and lock up a playoff spot.

A loss would give New England the division crown and make Buffalo potentially face the Pats a third time in the postseason.

Chicago Bears vs. Seattle Seahawks

  • Bears (+7) -110
  • Seahawks (-7) -110
  • Over 44 (-110)
  • Under 44 (-110)

These two are both coming off Monday and Tuesday night matchups, so expect this line to change frequently based on the injury after their Week 15 matchups.

Russell Wilson’s time with the Seahawks could be winding down and the struggles with D.K. Metcalf entering Week 15 has been horrendous to watch.

One of the better wideouts last season has been a complete bust in 2021. Their lack of a run game and a strong defense has left them on the short end of the stick in most of their games.

Chicago is hopeful of having a few positive moments before their disappointing 2021 campaign is over as well.

Pittsburgh Steelers vs. Kansas City Chiefs

  • Steelers (+10.5) -110
  • Chiefs (-10.5) -110
  • Over 46.5 (-110)
  • Under 46.5 (-110)

Ben Roethlisberger and the Steelers will be getting double digits on the road. Pittsburgh has gone 3-1 against the spread as a road team getting 10-plus points.

Big Ben should rely more on Diontae Johnson and Najee Harris, who are both coming off their worst games of the season.

Patrick Mahomes became the fourth quarterback in NFL history to throw three game-tying or lead-changing touchdowns in the fourth quarter or later of a game.

The Steelers don’t need to run the table with Baltimore, Cleveland, and Cincinnati having similar records. However, it is risky to have any more losses and we should have a highly motivated Pittsburgh squad at Arrowhead.

Denver Broncos vs. Las Vegas Raiders

  • Broncos (+1) -110
  • Raiders (-1) -110
  • Over 42 (-110)
  • Under 42 (-110)

The status of Teddy Bridgewater will be in question during the week, putting this line in question. Drew Lock is an average backup at best, but the Raiders could have health concerns on a short week with their matchup against the Browns.

This is one of those games one could stay away, or at least wait with all the recent fluidity of the NFL. We saw the Raiders go from slight underdogs to favorites and back to the dogs against the Browns.

Washington Football Team vs. Dallas Cowboys

  • Washington Football Team (+9.5) -110
  • Cowboys (-9.5) -110
  • Over 47.5 (-110)
  • Under 47.5 (-110)

The Dallas offense was far from its best against New York, but they dominated on defense and were able to run the ball with success. That could bode well against Washington, who has been searching for answers on the offensive end.

Injuries and health/safety concerns have been an issue for the past few weeks in the NFL. Dallas is fighting for the top seed depending on how Green Bay fares in their final three games.

Tampa Bay is coming off a recent loss, so the Cowboys have moved up to the number two seed.

Miami Dolphins vs. New Orleans Saints

  • Dolphins (+3.5) -110
  • Saints (-3.5) -110
  • Over 40.5 (-110)
  • Under 40.5 (-110)

Monday Night Football is coming to an end and there are only two weeks left. The Saints are suddenly in the playoff hunt and they have three manageable games.

  • Week 16: vs. Dolphins
  • Week 17: vs. Panthers
  • Week 18: at Falcons

If Minnesota, Philadelphia, and Washington all lose one more game and we see the Saints run the table then we would see them in the postseason. This value for Miami is due to their struggles with the Jets and the Saints recent domination over Tampa Bay.

Taysom Hill is often a question mark under center, but their defense dominated Tom Brady and handed him his third career shutout. It was the first time we had ever seen TB12 daily to score a point at home.

Betting on the NFL in Week 16

Be sure to check out the top NFL betting sites throughout the remainder of the regular season and throughout the postseason.

These games will frequently change throughout the week as injuries develop and have more clarity on them.

The value will be available to jump on for a few games, but others are worth the wait. Most players practice fully on Wednesday or Thursday, so be on the look to see if stars are missing in action.

Lastly, be sure to check out our free NFL picks page, where you can see all the previews and predictions for the upcoming week.

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