Betting Odds and Breakdown for NFL’s Wild Card Weekend (2022)

By Dan Vasta in NFL
| January 10, 2022 12:37 pm PST

The final weekend of the NFL season was off the rails, and it could have been the most entertaining season finale in NFL history.

We saw three overtime games, all of which had postseason implications. We nearly saw a tie in arguably the game of the season between the Chargers and the Raiders.

Everybody is pumped for Wild Card weekend with several intriguing matchups. This article will help you win your postseason bets and get you over the hump.

The 2022 NFL playoffs are here, and we need to discuss the odds and give a breakdown on all six matchups for Wild Card weekend.

Early NFL Betting Odds for Wild Card Weekend

  • Cardinals (+4) -105 vs. Rams (-4) -115
  • Eagles (+9.5) -115 vs. Buccaneers (-9.5) -105
  • 49ers (+3) -110 vs. Cowboys (-3) -110
  • Steelers (+13) -110 vs. Chiefs (-13) -110
  • Patriots (+4) +100 vs. Bills (-4) -120
  • Raiders (+6) +100 vs. Bengals (-6) -120

The regular season is over and what a ride it was. The top teams advanced to the postseason and now it is win or go home mode.

The following odds above are from, so be sure to check out their site for the rest of the postseason. The playoff predictions could be absurd since the matchups over the years have had upsets along the way.

There are several games that will impact the top seeds. Remember, the lone teams with byes will face the lowest seeded teams regardless of which road team wins.

This means if all three road teams were to win, the seventh seeded team would then travel to the top seed the following week. Here is your Wild Card weekend slate to kickoff off the NFL postseason.

Arizona Cardinals vs. Los Angeles Rams

  • Cardinals (+4) -105
  • Rams (-4) -115
  • Over 50 (-110)
  • Under 50 (-110)

Sean McVay is hopeful that Matthew Stafford will grab his first postseason victory of his career. The pieces are in place and the pleasant return of Cam Akers (Achilles) should give them more balance.

While they were anything but against the 49ers, the Rams will have a chance to control the line of scrimmage and win the battle of time of possession.

Is this finally the first victory for Stafford in postseason play? The Rams have gone 3-3 ATS and outright in their past six postseason games.  

All of those have been under McVay, but he has never had a gunslinger like Stafford before. 

Kyler Murray and Arizona are two weeks removed from winning on the road at Dallas. The run-stuffing ability that Arizona showed in their narrow victory was impressive.

Kyler Murray
Getting production from Chase Edmonds (ankle) and James Conner (heel) have allowed Murray to play with more relaxation in the pocket by avoiding those obvious passing downs.

They needed that win at Dallas since the offense lost some of its confidence without DeAndre Hopkins. Christian Kirk, AJ Green, Rondale Moore, and Antoine Wesley have shown enough skills to move the chains.

The bend but don’t break pass defense of the Rams will get tested early and often in this one. Ultimately, the pressure of their front four will dictate this elite matchup. Forcing Murray into quick decisions and keeping him in the pocket will be the strategy.

Arizona has failed to cover the spread in their past four postseason games, and this will be the first postseason matchup for Kliff Kingsbury and Kyler Murray. Losing to Seattle to end the year wasn’t exactly the momentum they were looking for either.

While the Cardinals have played much better on the road, the Rams have played in a few more highly contested games as of late.

For those wondering when and where all these games are being placed, take some notes with six pivotal postseason matchups this weekend.  

Philadelphia Eagles vs. Tampa Bay Buccaneers

  • Eagles (+9.5) -110
  • Buccaneers (-9.5) -110
  • Over 49.5 (-110)
  • Under 49.5 (-110)
Rob Gronkowski

Tom Brady will end up playing in consecutive Wild Card weekends since the 2006 and 2007 postseason. TB12 ended up winning both contests but fell short of a Super Bowl.

Last season was a magical ride thanks to all the momentum they garnered from their bye week after a loss to the Chiefs. This season, the offensive weapons have been dropping like flies.

The one consistent performer who reached some incentives against the Panthers thanks to Brady, was Rob Gronkowski. The past two games have been vintage Gronk and the only thing missing was a touchdown spike.

  • vs. Panthers: 10 targets, 7 receptions for 137 yards
  • at Jets: 10 targets, 7 receptions for 115 yards

If Tampa Bay is going to advance deep into the postseason, this is a target Brady will need to continue to connect with in their sleep like the good old days.

Winning four Super Bowls together has its privileges and the tandem has been money for years.

This is also your yearly reminder that Brady has more than double the wins any other signal-caller has in postseason history. The 34 wins is miles ahead of Joe Montana at 16 and even the active players are looking up to the Tampa passer.

Active Quarterbacks with the Most Playoff Wins Wins
Ben Roethlisberger 13
Aaron Rodgers 11
Joe Flacco 10

Philadelphia has done well against the number as a road underdog in the playoffs. They are 6-1 ATS as a road underdog dating back to 2002, when they knocked off the second-seeded Bears.

Jalen Hurts (ankle) will need to play well on the road and find ways to move the chains against a Bucs offense that is likely to have no issues scoring 25-plus points.

Philadelphia is one of the bigger dogs of the weekend and many believe they stand no shot at making a run at the Super Bowl.

Be sure to check out our recent blog on why the top Super Bowl contenders cannot get over the hump and claim the Lombardi.

San Francisco 49ers vs. Dallas Cowboys

  • 49ers (+3) -110
  • Cowboys (-3) -110
  • Over 50 (-105)
  • Under 50 (-115)

The Dallas Cowboys have the third longest NFC Championship drought, trailing only Detroit and Washington. The last appearance in the NFC title game was 1995 and the Cowboys are looking to end that drought.

In fact, this Dallas and San Francisco matchup is the first matchup between these two since the 1995 NFC Championship game, where the 49ers prevailed before capturing the Super Bowl.

That is oddly enough the last time the Cowboys have reached the NFC title game and is also the last Super Bowl for the 49ers (Dallas won the year prior and after).

Dak Prescott is right there set to win the NFL Comeback Player of the Year. The Cowboy signal-caller has meant so much to his team and the squad ended up covering in every game against NFC East competition.

He has quietly already played in three postseason games and is looking to get closer to that much-needed Super Bowl appearance that the Cowboy nation is craving. Dak is at his best when he is on the move and making throws on the run.

If he can take care of the football, Dallas should be a challenge to defend. In playoff games with Dak under center, the Cowboys are 0-3 ATS with a narrow victory over Seattle.

Mike McCarthy has a career postseason record of 10-8 and is entering his first season with Dallas. He had quite the postseasons with Green Bay, although many at Lambeau wished he had a few more postseason pushes towards additional Super Bowl trips.

The 49ers have an awful track record recently as a road underdog. San Francisco is 0-8 straight up with a 1-7 record ATS, which dates to 1987!

The quarterback battle between Prescott and Jimmy Garoppolo will be a fun one that may decide which historically successful franchise advances.

New England Patriots vs. Buffalo Bills

  • Patriots (+4) -103
  • Bills (-4) -117
  • Over 43.5 (-110)
  • Under 43.5 (-110)

Picking against Bill Belichick is risky due to all the success he has had. Tying Don Shula with his 19th postseason appearance only gives him more reasons to be considered the best ever.

At 31-12, Belichick has proven to be more reliable than any other coach on the sidelines. Their defensive ability to limit superstar running backs and wide receivers are tremendous. The list of other coaches that are looking up to the 31 wins aren’t too shabby, either.

  • Tom Landry: 20 wins
  • Don Shula: 19 wins
  • Joe Gibbs: 17 wins
  • Andy Reid: 17 wins
  • Chuck Noll: 16 wins

Fading the Patriots in the postseason as an underdog is a struggle. Choose wisely and the numbers suggest to not even consider doing such a thing.

Since 2002, New England has gone 6-3 against the spread and 6-3 straight up as an underdog. We have only seen nine postseason games out of the 42 he has coached in which his New England Patriots were an underdog.

Josh Allen has been incredible this season thanks to the arm strength and ability to find paydirt near the goal-line. The size of most quarterbacks can get injured when taking on contact, but Allen has the size and youth on his side.

He recently cooked up the New England defense and is looking forward to a third meeting with more at stake.

Reaching the AFC title game last season is a nice feather in the cap that he can use to his advantage. Threading the needle to Stefon Diggs is often the best decision he can make, but he has turned Dawson Knox and Gabriel Davis into reliable threats in the red zone.

Allen and his rocket arm will be ready to take over and carry the franchise similar to what he showed last season. The experience of being in the playoffs for a third year in a row is pivotal. I love the upside.

What he showed in the three games last season gave the Buffalo fanbase the hope that we could see three-plus more games like such.

Josh Allen
  • Indianapolis: 324 yards passing, 3 Total TD
  • Baltimore: 206 yards passing, 1 Pass TD
  • Kansas City: 287 yards passing, 2 Pass TD

Those are elite numbers, and the Bills are capable of putting similar numbers this postseason. Their defense seems to be poised for more success this time around, but they hung in there the first two rounds against the Colts and Ravens last season.

Las Vegas Raiders vs. Cincinnati Bengals

  • Raiders (+6) +100
  • Bengals (+3.5) -120
  • Over 49 (-110)
  • Under 49 (-110)

Joe Burrow has been a superstar this season, especially down the stretch run. The Bengal signal-caller is looking to win the first postseason game for Cincinnati since Boomer Esiason in 1990.

The future looks bright for the offense. However, the Bengals have lost eight straight postseason games and it has been 31 seasons since a playoff victory.

The rankings for this franchise is a struggle and even the worst franchises in the NFL are looking a bit better from a production standpoint compared to the current AFC North champions.

  • Consecutive playoff losses: 8 (No. 31, second worst active streak)
  • Seasons since last playoff win: 31 (longest active drought)
  • Years since last Conference Title Appearance: 33 (longest active drought)
Ja’Marr Chase

Luckily the Bengals have Joe Burrow and Ja’Marr Chase, who have done a tremendous job improving the franchise. The tandem has made life a challenge for opposing defenses and the youngsters will be looking to have a few deep ball connections on Wild Card weekend.

The Raiders will have their hands full against Ja’Marr Chase. He has been a monster in his rookie campaign. 

Joe Burrow will get his yards with Tee Higgins and Tyler Boyd underneath, but they could take big plays away from Chase. He was a superstar at LSU with Burrow threading the needle and he has turned into one of the better passing targets in all of football.

The key will be controlling the line of scrimmage and setting the edge against Joe Mixon. The Bengal offense is loaded with stars, but they are all a bunch of young pups that will be going against a hungry Las Vegas squad.

This is going to be a fun showdown, but the Bengals are in a nasty drought. They have lost eight straight postseason matchups and are 0-7-1 against the spread in those games.

In fact, Cincy has a few droughts to break or else it is going to be a long offseason of another disappointing performance in the postseason.

  • Current losing streak: 8 games (second longest drought among active teams)
  • Last Playoff Victory: 1990 Wild Card over Houston (31 seasons since last win is longest active streak in NFL without a playoff win)
  • Last Conference Championship Appearance: 33 seasons ago, 1988 (longest active drought in NFL)

Woof, those are ugly droughts that the franchise has endured over the past few decades. Joe Burrow and this franchise should be back for many years ahead, but a victory would go a long way for the future of this squad.

The Raiders have lost their past five postseason road games, dating back to 1991. It is crazy to think that this will only be the sixth road game since 1991 for the Raiders in the postseason.

Somebody is going to have their drought end in this wacky AFC matchup between the four and five seeds.

Pittsburgh Steelers vs. Kansas City Chiefs

  • Steelers (+13) -110
  • Chiefs (-13) -110
  • Over 46.5 (-110)
  • Under 46.5 (-110)

One of the more dramatic games of the season saw the Steelers win an epic overtime victory over the Ravens to grab the last seed in the AFC.

They likely didn’t sleep on Sunday after staying up late to watch their playoff hopes hang on by a thread.

Thanks to the Raiders avoiding a tie and beating the Chargers, Pittsburgh and Ben Roethlisberger are magically in the postseason.

Big Ben is 3-2 as a road underdog in his career with a 3-1-1 record ATS. Roethlisberger is only 4-3-1 as an underdog combined, so he has fared better with his back against the wall.

The Chiefs are back in the postseason and saw momentum in their favor after a comeback victory over the Broncos.

The defensive ability had some issues defending the Denver rushing attack, but they made a few game-winning plays when the game was on the line. Nick Bolton as a rookie had a scoop-and-score with the game on the brink.

Under Patrick Mahomes, the squad has gone 6-2 straight up and 5-3 against the spread in postseason play.

Kansas City is attempting to become the fourth team to reach three straight Super Bowls.  Oddly enough, the other three teams to reach three straight Super Bowls were all from the AFC and they all hail from the AFC East.

  • New England (2017-19)
  • Miami (1972-74)
  • Buffalo (1991-94)

Mahomes has never been an underdog in the postseason and is rarely one in the regular season. At 6-2 in his career, the Chief signal-caller has gone 5-3 ATS in the postseason.

Betting the NFL on Wild Card Weekend

This season has flown by and there have been several injuries and updates every week. We are likely in for a tremendous postseason with several quarterback duels that should come down to the wire. Fasten your seat belts and relax on the couch, the best time of the season is upon us.

The amount of chaos is expected, and more research will improve your chances to get that winning wager. There is a free NFL picks page, where all the dissection and predictions will be at the click of a button for your postseason fix.

Be sure to check out the top NFL betting sites as the postseason will continue to pick up steam as the weeks progress.

For another look at all of these matchups, check out our NFL Wild Card predictions and best bets below.



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